A5078991481- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Bone Tissue Engineering Materials
- Cervical and Thoracic Myelopathy
- Silk-based biomaterials and applications
- Scoliosis diagnosis and treatment
- Musculoskeletal pain and rehabilitation
- Periodontal Regeneration and Treatments
- Total Knee Arthroplasty Outcomes
- Nerve injury and regeneration
- Orthopaedic implants and arthroplasty
- MicroRNA in disease regulation
- Pelvic and Acetabular Injuries
- Bone and Joint Diseases
- Monoclonal and Polyclonal Antibodies Research
- Spinal Hematomas and Complications
- Bacterial biofilms and quorum sensing
- Pathogenesis and Treatment of Hiccups
- Shoulder and Clavicle Injuries
- Inflammatory Bowel Disease
- T-cell and B-cell Immunology
- Fatty Acid Research and Health
- Barrier Structure and Function Studies
- Hip and Femur Fractures
- Blood transfusion and management
Soochow University
2014-2024
First Affiliated Hospital of Soochow University
2014-2024
Guangzhou Medical University
2020-2022
Suzhou Research Institute
2019
Osteoarthritis (OA) is characterized by the progressive destruction of articular cartilage, which involved in imbalance between extracellular matrix (ECM) synthesis and degradation. MicroRNA-140-5p (miR-140) specifically expressed cartilage plays an important role OA-induced The aim this study was to investigate (1) whether intra-articular injection melatonin could ameliorate surgically induced OA mice (2) regulate matrix-degrading enzymes at posttranscriptional level targeting miR-140. In...
Yes-associated protein (YAP) and extracellular signal-regulated kinase (ERK) have been considered as key regulators in tissue homeostasis, organ development, tumor formation. However, the roles of YAP ERK mediating strain mechanosensing growth plate cartilage not determined. In this study, chondrocytes obtained from 2-week-old Sprague-Dawley rats were subjected to mechanical with different magnitudes durations at a frequency 0.5 Hz. We found that activation response was time magnitude...
Objective . To investigate the change of spinopelvic sagittal balance and clinical outcomes after posterior lumbar interbody fusion (PLIF) in patients with degenerative spondylolisthesis (DS), especially relationship between parameters persistent low back pain (PLBP). Methods 107 who were diagnosed DS underwent PLIF our department enrolled retrospectively present study. Sagittal including lordosis (LL), segmental (SL), height disc (HOD), sacral slope (SS), pelvic incidence (PI), tilt (PT)...
Background: Patients with inflammatory bowel disease-peripheral arthritis (IBD-PA) often accompany by sleep problems, but few studies have used polysomnography to investigate the objective characteristics of IBD-PA. Methods: in IBD-PA group, disease (IBD) healthy control (HC) group were examined (PSG) and compared. PSG Pittsburgh Sleep Quality Scale (PSQI) indices compared between active remission patients. The correlation activity quality patients was analyzed. influencing factors...
Polyurethane (PU) and polyurea (PUA) materials have shown significant potential for application in tissue repair. Herein, we design a glycerol ethoxylate (PEG)-based poly(urethane-urea) bone The polymer precursor was prepared from the reaction of PEG isophorone diisocyanate (IPDI). cystine dimethyl ester used as cross-linker preparation elastomers. material further strengthened by physical blending nano-hydroxyapatite (nHA). biological properties final were evaluated mechanical testing,...
BACKGROUND Despite literature supporting the efficiency of percutaneous balloon kyphoplasty (PKP) in treating osteoporotic and malignant vertebral compression fractures, few reports exist that document its use for treatment symptomatic Schmorl's nodes (SNs) refractory to conservative treatment. Patients with SNs could have pain vertebrae similar an acute fracture. MRI is very helpful diagnosing when x-ray CT scan are unremarkable. In painful cases, bone marrow around hyperintense on...
Purpose: To introduce the intraoperative O-arm-assisted pedicle screw insertion without any navigation system in treatment of thoracic vertebrae fracture and compare it to conventional fluoroscopy (C-arm)-assisted technique. Methods: About 156 screws were inserted 23 patients (C-arm group), 208 30 (O-arm group). The postoperative computed tomography images analyzed for violation based on Gertzbein classification. total surgery time, average time required inserting a screw, mean action times...
The study investigates the positive effects of phillygenin on intestinal tight junction via let-7b signaling pathway and regulation microbiota. expression levels proteins are determined through PCR Western blot. DSS-induced mice colitis is used to verify protective barrier junction. Fecal microbiota transplantation role detected in colon tissues patients with acute stercoral obstruction. Phillygenin could promote occludin, which might be inhibited by inhibitor. showed that lower colonic...
Objectives Recent studies have indicated that radiomics may excellent performance and clinical application prospects in the differential diagnosis of benign malignant vertebral compression fractures (VCFs). However, multimodal magnetic resonance imaging (MRI)‐based model is rarely used VCFs, limited to lumbar. Herein, this study intends develop validate MRI models for diagnoses VCFs patients. Methods This cross‐sectional involved 151 adult patients diagnosed with VCF The First Affiliated...
Inflammatory bowel disease arthritis (IBDA) threatens patients' physical and mental health. Therefore, patients need not only therapy, but also adequate health education psychological support. This study was designed to explore the effect of based on narrative medicine combined with an online patient mutual assistance group that IBDA.A total 120 IBDA were randomly divided into four groups (30 per group). Patients in control given routine premise treatment. The three treatment medicine,...
Purpose: The purpose of this study was to investigate the sagittal balance cervical spine and clinical outcomes anterior discectomy fusion (ACDF) for treatment spondylotic myelopathy explore whether is related incidence postoperative axial symptoms. Methods: Sixty-seven consecutive patients who underwent ACDF from January 2014 December 2016 were enrolled in our study. Sagittal parameters (global lordotic angle, segmented T1 slope, C2–7 vertical axis [C2–7 SVA] recorded preoperative period at...
The properties of polymethyl methacrylate (PMMA) bone cement make it a popular filling material. However, its disadvantages, such as lack biodegradability and osteogenesis, restrict clinical application. Studies have indicated the osteogenic