An effective strategy to synthesize multifunctional materials is the incorporation of functional organic moieties and metal oxide clusters via self-assembly. A rare radical-doped zinc-based host–guest crystalline material was synthesized with a fast-responsive reversible ultraviolet visible light photochromism, photocontrolled tunable luminescence, highly selective photocatalytic oxidation benzylic alcohols as result blending distinctively different components, naphthalenediimide tectons,...

14 new structures of isoxazole-moiety-containing quinazoline derivatives(3a~3n) were synthesized for the first time and characterized by IR, 1H NMR, 13C ESI-MS. Subsequently, their in vitro anticancer activity against A549, HCT116 MCF-7 cell lines was preliminarily evaluated using MTT method. Among them, most compounds showed good to excellent activity, especially 3d, 3i, 3k 3m exhibited more potent lines, which can be regarded as promising drug candidates development drugs. Keywords:...

Two rare copper-based host–guest crystalline compounds were synthesized with different photoresponsive reversible visible light photochromism as a result of blending distinctively functional components, naphthalenediimides (NDIs) tectons and polyoxometalates. A slight adjustment the substituent diimide nitrogens, from rigid to semirigid ligands, will in modes anion−π interactions, which eventually lead structures sensitivities light. The unique interactions impart significant impacts on and,...

Seven new structures of an isoxazole moiety containing ferrocene derivatives (3a–3g) were firstly synthesized and characterized by 1H NMR, 13C ESI-MS. Subsequently, their in vitro anticancer activity against A549, HCT116 MCF-7 cell lines was preliminarily evaluated using the MTT method. Among them, 3d exhibited a wide spectrum most potent A549 (IC50s: 0.747 3.65 nM, respectively) as compared with reference drug gefitinib 17.90 21.55 μM, respectively). can be seen best candidate for development drugs.

To improve the biological activities of rupestonic acid, 21 new acid fatty ester derivatives (2a-2h) and aromatic (2i-2u) were synthesized preliminarily evaluated for their anti-influenza activity in vitro by national center drug screening China, using Oseltamivir Ribavirin as reference drugs. The results showed that 2l (<TEX>$IC_{50}=0.5{\mu}mol/L$</TEX>) exhibited potent <TEX>$A_3$</TEX> viral among compounds was 10-fold more than (<TEX>$IC_{50}=5.1{\mu}mol/L$</TEX>).

Imidazole, 1,2,4-triazole, indole, and benzotriazole undergo conjugate additions with α, β-unsaturated carbonyl compounds in the presence of anhydrous potassium phosphate at ambient temperature to afford corresponding Michael adducts excellent yields.

Rupestonic acid (isolated from the Chinese traditional medicine Artemisia rupestris L.) is a sesquiterpene with multifunctional groups and possess higher activity against influenza virus B. In order to improve biological of rupestonic acid, many derivatives have been synthesized their anti-influenza was screened. This review describes studied by our researching group.

Under the guidance of our previous work, we synthesized 21 new structures quinazolines (3a~3u) and evaluated their in vitro anticancer activity against A549, HCT116 MCF-7 cell lines using MTT method. Most compounds showed good to excellent activity. In particular, 3o (regarded as erlotinib analogues) has marked (IC50s: 4.26, 3.92 0.14 μM, respectively) compared with standard drug gefitinib 17.9, 21.55 20.68 respectively), which can be regarded best candidate for development drugs.

Areca catechu L. is a palm plant, widely distributed in the tropical and subtropical districts, such as southeast Asia Hainan, Taiwan, Hunan Fujian China.Some studies on chemical components (alkaloids, flavonoids, tannins, triterpenes, fatty acids, etc.) biological activities (anti-bacterial, anti-viral antitumor, anti-oxidation, anthelmintic action, effects nervous system digestive system) have been reported.This review briefly describes research progress of L, to provide reference researchers.

Background: Cancer is a major health problem worldwide, the relative mortality rate caused by cancer still very high even in developed countries. Although remarkable success has been achieved: some small molecule anticancer agents have approved U.S. Food and Drug Administration (FDA) clinics are currently clinical trials, chemotherapy highly inadequate. It essential to find novel structures, low side effect more potent agents. Thieno[2,3-d]pyrimidine derivatives also exhibited wide range of...

21 new structures of isoxazole-moiety-containing thieno[2,3-d]pyrimidine derivatives(3a~3u) were synthesized for the first time and characterized using IR, 1H NMR, 13C ESI-MS elemental analysis techniques. And then their in vitro anticancer activity against lung cancer A549, colorectal HCT116 breast MCF-7 cell lines was preliminarily evaluated MTT method. Among them, most compounds exhibited good to excellent activity. In particular, 3g, 3j 3n a broad spectrum more potent lines, which can be...

Aims: The aim of this study is to find the anticancer lead compounds or drug candidates from Chinese Traditional Plant Medicine Ajuga decumbens Thunb. Background: has been used in clinical for a long time China and was selected “Chinses Pharmacopoeia” (part I 1977) its wide spectrum biological activities: such as anticancer, antioxidant, antifeedant, antibacterial, anti-inflammatory, antihyperlipidemic, anti-cholinesterase cytotoxicity activities. However, there are relatively fewer studies...

19 Aromatic ring and L-amino acid ester contained rupestonic amide derivatives 2a~2l, 3a~3g were synthesized preliminarily evaluated in vitro against influenza virus <TEX>$A_3$</TEX>,B herpes simplex type 1 (HSV-1), 2(HSV-2) by the national center for drug screening of China. The rusults showed that 2i possessed highest inhibition both <TEX>$A_3\;(TC_{50}\;=\;120.6\;{\mu}mol/L,\;IC_{50}=\;19.2\;{\mu}$</TEX>mol/L, SI = 6.3) B...

The essential oil was obtained from the seeds of Garcina kola and its compositions were investigated by GC-MS ICP-MS, respectively. 74 organic compounds 9 trace elements beneficial to human health confirmed in this oil. Then, vitro antioxidant anticancer activities evaluated accordingly. results showed that exhibited stronger activity against DPPH⸱ with scavenging rate 94.19% at 0.2 mg/mL, as well potent inhibition gastric cancer, lung cancer(A549) Hela cell lines inhibitions 96.397%±0.929,...

A new triterpenoid was isolated from the roots of Jasminum sambac (L.) Ait. Its structure elucidated by 1D and 2D NMR analysis, single crystal X-ray diffraction, HRESIMS. This compound exhibited potent in vitro anticancer efficacy against MCF-7 cell lines with IC50's 193.5 μM for 24 h 154.6 48 h.