A5051885649- Obsessive-Compulsive Spectrum Disorders
- Lysosomal Storage Disorders Research
- Autism Spectrum Disorder Research
- Glycogen Storage Diseases and Myoclonus
- Eating Disorders and Behaviors
- Attention Deficit Hyperactivity Disorder
- Child and Adolescent Psychosocial and Emotional Development
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Behavioral and Psychological Studies
- Genomics and Rare Diseases
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neurological diseases and metabolism
- Ginkgo biloba and Cashew Applications
- Chronic Lymphocytic Leukemia Research
- Neurological and metabolic disorders
- Metabolism and Genetic Disorders
- Epilepsy research and treatment
- Parkinson's Disease Mechanisms and Treatments
- Magnetic Bearings and Levitation Dynamics
- Botulinum Toxin and Related Neurological Disorders
- Diet and metabolism studies
- RNA regulation and disease
- Endoplasmic Reticulum Stress and Disease
- Wireless Power Transfer Systems
University of Rochester Medical Center
2020-2025
University of Rochester
2017-2024
University of South Florida
2024
Johns Hopkins University
2024
Pennsylvania State University
2024
Kennedy Krieger Institute
2024
Approximately 20%-40% of individuals with Tourette syndrome (TS) have rage attacks (RAs), which are recurrent, explosive behavioral outbursts that can cause significant functional impairment. Despite the impact RA in TS, there has been limited research on treatment, and most studies focused pharmacologic interventions. Nonpharmacologic interventions potential to improve symptoms fewer side effects.
Tics and tic disorders can significantly impact children, but limited screening tools diagnostic challenges may delay access to care. The current study attempted address these gaps by evaluating sensitivity specificity of the Motor or Vocal Inventory (MOVeIT), a symptom screener, Description Tic Symptoms (DoTS), brief assessment for disorders. Children (n = 100, age 6–17 years old) with attending Tourette specialty clinic community-recruited sample without tics completed gold-standard...
Tics are unwanted, repetitive movements and sounds that frequently present during childhood. They typically brief purposeless, but can create significant distress for individuals, often co-occur with other neuropsychiatric conditions. Thus, early identification of tics is warranted. Unfortunately, misdiagnosed, because may wax wane, be difficult, especially in the context routine clinical visits. There limited tools used to reliably identify practice, non-specialty settings. The purpose...
<h3>Objective</h3> To develop a disease-specific staging system for CLN3 disease and to test the hypothesis that salient discrete clinical features of may be used define stages by analyzed data from an 18-year-long natural history study. <h3>Methods</h3> A proposed system, Staging System (CLN3SS), was based on clinically meaningful endpoints. The relationships between stage age, Unified Batten Disease Rating Scale (UBDRS) physical severity score, UBDRS capability impairment subscale scores...
Neuronal intranuclear inclusion disease is a rare, neurodegenerative disorder with onset in childhood. We report single case natural history over 10 years and present review of juvenile parkinsonism neuronal disease. Our patient was initially seen at the University Rochester age 12 after 4 progressive dysarthria, dysphagia, clumsiness. His neurologic examination notable for parkinsonism. He had excellent initial response to levodopa, but subsequently developed dopa-induced motor...
This study combines data from five studies in a quantitative modeling approach to improve identification of tics and tic disorders using two questionnaires (the Motor or Vocal Inventory Tics the Description Tic Symptoms), administered parents children
Youth with intellectual and developmental disabilities typically have higher rates of tics stereotypies compared to children otherwise typical development. Differentiating between these two pediatric movement disorders can be challenging due overlapping clinical features, but is relevant distinct treatment modalities. The current study evaluated sensitivity specificity a tic screening measure, the Motor or Vocal Inventory Tics (MOVeIT) in sample enriched for stereotypy tics. Children (n =...
To characterize sensory processing in youth with chronic tic disorder (CTD).
Tourette syndrome (TS) is defined by multiple motor tics and one or more phonic with a symptom duration of >1 year. Coprophenomena are uncommon characterized obscene sounds, words, gestures. Youth TS commonly have psychiatric co-occurring conditions such as attention-deficit hyperactivity disorder obsessive-compulsive reported lower scores on measures individual family functioning than youth without TS. This study aimed to determine associations among condition symptoms, tic severity,...
Accurate classification is essential for addressing childhood movement disorders (MD), but the common coexistence of multiple MDs complicates this process.
<h3>Objective:</h3> To evaluate the feasibility and acceptability of Mightier as a therapeutic intervention for rage attacks in youth with TS. <h3>Background:</h3> Approximately 20–40% individuals Tourette Syndrome (TS) have attacks, which are recurrent, explosive behavioral outbursts that can cause significant functional impairment. Despite impact TS, there has been limited research on treatment, most studies focused pharmacologic interventions. Non-pharmacologic interventions potential to...
<h3>Objective:</h3> To assess the characteristics of patients presenting with functional tics (FT) at two different pediatric neurology sites. A subaim was to for differences in presentations FT between cisgender versus non-binary or transgender youth. <h3>Background:</h3> In years 2020 and 2022, coinciding COVID-19 pandemic, we have seen a large increase incidence adolescents (ages 12–18 years). Understanding how differs from tic disorders whether presents differently among gender identity...
A 14-year-old boy presented to the University of Rochester Pediatric Movement Disorder clinic for abnormal movements 1 year's duration. He was referred evaluation complex tics. His were stereotyped and often preceded by a blank stare, sometimes associated with "guttural sound." also reported having "numb" sensation prior movements. denied volitional control or ability suppress them. only occurring during day although parents recalled period nightly episodes witnessed while sharing hotel room...