A5027277686- Parkinson's Disease Mechanisms and Treatments
- Lysosomal Storage Disorders Research
- Muscle metabolism and nutrition
- Botulinum Toxin and Related Neurological Disorders
- Sports Performance and Training
- Cardiovascular and exercise physiology
- Health Systems, Economic Evaluations, Quality of Life
- Glycosylation and Glycoproteins Research
- Obesity, Physical Activity, Diet
- Physical Activity and Health
- Vitamin D Research Studies
- Neurological disorders and treatments
- Cerebral Palsy and Movement Disorders
- Glycogen Storage Diseases and Myoclonus
- Health and Lifestyle Studies
- Parkinson's Disease and Spinal Disorders
- Health Policy Implementation Science
- Pineapple and bromelain studies
- Tryptophan and brain disorders
- Autism Spectrum Disorder Research
- Genomics and Rare Diseases
- Autoimmune and Inflammatory Disorders Research
- Mental Health Research Topics
- Cannabis and Cannabinoid Research
- Leptospirosis research and findings
University of Utah
2022-2023
University of Rochester
2017-2022
Lipscomb University
2020-2021
University of Rochester Medical Center
2019-2021
Eli Lilly (United States)
2020
University of Colorado Anschutz Medical Campus
2020
Michael J. Fox Foundation
2020
Secretaría de Salud de Bogotá
1986
There is rising interest in remote clinical trial assessments, particularly the setting of COVID-19 pandemic.To demonstrate feasibility, reliability, and value visits a phase III individuals with Parkinson's disease.We invited disease enrolled (STEADY-PD III) to enroll sub-study video-based visits. Participants completed three over one year within four weeks an in-person visit assessments performed during visit. We evaluated ability complete scheduled remotely; agreement between outcome...
To explore disease burden in Parkinson (PD) by evaluating the prevalence of symptoms and key milestones (critical events, e.g., hospitalization or frequent falls) their association with quality life (QOL) those PD.We created pretested an online needs assessment survey to evaluate clinical characteristics, QOL, symptom prevalence, critical event frequency among PD. We recruited individuals self-reported Hoehn Yahr stage II-V PD through postings email Davis Phinney Foundation. used logistic...
Use of video research visits in neurologic conditions is rising, but their utility has not been assessed atypical parkinsonian syndromes. We sought to evaluate the diagnostic concordance between video-based vs self-reported diagnoses multiple system atrophy, progressive supranuclear palsy, dementia with Lewy bodies, and corticobasal syndrome. also patient satisfaction visits.We conducted a study individuals an syndrome enrolled The Michael J. Fox Foundation's Trial Finder. Participants...
Endocannabinoid-metabolizing enzymes are downregulated in response to lipopolysaccharide (LPS)-induced inflammation mice, which may serve as a negative feedback mechanism increase endocannabinoid levels and reduce inflammation. Increased plasma of the pro-inflammatory cytokine interleukin-6 (IL-6) decreased fatty acid amide hydrolase (FAAH) activity peripheral lymphocytes from individuals diagnosed with Huntington’s disease (HD) suggests that similar system between operates humans. We...
Purpose: To determine the effects of dietary nitrate supplementation, in form red spinach extract (RSE), on adaptations to offseason training collegiate athletes.Methods: Sixteen Division I male baseball athletes (20.5 ± 1.7y, 90.4 0.5 kg) enrolled this study and were randomized into a RSE (n = 8) or placebo 8; PL) group. Athletes completed an 11-week resistance program during offseason, which consisted 2-3 workouts per week upper lower-body exercises baseball-specific training. consumed (2...
To demonstrate the feasibility, reliability, and value of conducting web-based clinical trial assessments in individuals with Parkinson disease (PD).
PURPOSE: To evaluate the effects of whey protein supplementation in adolescent soccer players on body composition and performance over a 10-week competitive season double-blind, randomized controlled trial. METHODS: Adolescents athletes (n = 22; 59% female, age: 15.6 ± 0.2; BMI percentile: 55.9 6.2%) underwent following assessments at pre- post-intervention: fat mass fat-free (via air displacement plethysmography), timed sprint 30-yard dash), estimated VO2max (using 1.5-mile run protocol),...
Wednesday, April 29April 14, 2020Free AccessQuantitative Gait Analysis in CLN3 Disease (477)Grace Zimmerman, Amy Vierhile, Heather Adams, Jonathan Mink, and Erika AugustineAuthors Info & AffiliationsApril 2020 issue94 (15_supplement)https://doi.org/10.1212/WNL.94.15_supplement.477 Letters to the Editor
Objective: To demonstrate the feasibility, reliability, and value of conducting virtual research visits in individuals with Parkinson disease (PD). Background: Increasing interest has focused on use given rising cost difficulties recruitment retention clinical trials. Virtual have potential to reduce infrastructure costs, expedite recruitment, improve through improved accessibility convenience trial participation. Design/Methods: We are an add-on study 40 PD enrolled phase 3 STEADY-PD III....
Objective: To pilot the use of a trigger-based method for specialty Palliative Care referral in individuals with Parkinson disease (PD). Background: There is recognition benefit PD. However, optimal methods to operationalize remain unclear. Oncology has explored triggers (specific symptoms or events) prompt Care, but their not been assessed Design/Methods: We identified potential using questionnaire (triggers: uncontrolled depression, pain, fatigue; ≥3 falls, ≥10 pounds weight loss,...
May 7, 2019April 9, 2019Free AccessThe palliative needs of individuals with Parkinson disease (S24.004)Christopher Tarolli, Grace Zimmerman, Peggy Auinger, Scott McIntosh, Robert Horowitz, Benzi Kluger, E. Ray Dorsey, and HollowayAuthors Info & AffiliationsApril 2019 issue92 (15_supplement)https://doi.org/10.1212/WNL.92.15_supplement.S24.004 Letters to the Editor
May 7, 2019April 9, 2019Free AccessVideo research visits for atypical parkinsonian syndromes among Fox Trial Finder participants (P3.8-006)Christopher Tarolli, Grace Zimmerman, Steven Goldenthal, Blake Feldman, Sarah Berk, Bernadette Siddiqi, Catherine Kopil, Sohini Chowdhury, Kevin Biglan, E. Ray Dorsey, and Jamie AdamsAuthors Info & AffiliationsApril 2019 issue92 (15_supplement)https://doi.org/10.1212/WNL.92.15_supplement.P3.8-006 Letters to the Editor
Vitamin D deficiency is prevalent among active adults. Commonly, individuals opt to consume a multivitamin product correct this deficiency. However, many multivitamins are often under-dosed compared current evidenced-based recommendations. Furthermore, some companies offer variety of vitamin formulations, with the claim improving nutrient absorption. PURPOSE: To compare effects two different forms (liquid vs. capsule) low-dose on 25(OH) status following 10-weeks supplementation. METHODS:...
PURPOSE: A decline in fitness levels of both children and young adults has been reported over the last two decades. The purpose this study was to determine what extent claim is true, which components may be involved decline. METHODS: Researchers examined several fitness, including estimated cardiorespiratory muscular percent body fat, max index (BMI) during 1999. Subjects for original were 72 college females enrolled general education classes. assessment repeated at same university 2019 with...
Abstract Introduction Chronic diseases are more prevalent among populations with greater daily sedentary time and insufficient sleep duration. Yet, little is known about the potential links between behavior. Early findings from recent studies show variable bidirectional associations duration behavior, based on population studied. The purpose of this investigation was to measure between: (1) next day; (2) same study day/night, during a extension intervention. Methods Data collection ongoing....
Dietary nitrates have been shown to increase vasodilation, mitochondrial efficiency, muscle contractility, and reduce ATP turnover which has led improvements in measures of athletic performance previous work. PURPOSE: To observe the effects dietary form red spinach extract (RSE) on Division I collegiate baseball players following off-season training health measures. METHODS: male athletes (N = 16; 20.5 ± 1.7y; 90.4 10.5 kg; 1.82 0.61 m) participated this doClinuble-blind, placebo-controlled,...
To create a system to categorize confidence in the diagnosis of CLN3 disease.