A5034140058- Neuropeptides and Animal Physiology
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Gut microbiota and health
- Dietary Effects on Health
- Regulation of Appetite and Obesity
- Inflammatory mediators and NSAID effects
- Spectroscopy Techniques in Biomedical and Chemical Research
- interferon and immune responses
- Hippo pathway signaling and YAP/TAZ
- Cancer, Hypoxia, and Metabolism
- Inflammasome and immune disorders
- Apelin-related biomedical research
- Immune responses and vaccinations
- Cancer Immunotherapy and Biomarkers
- 3D Printing in Biomedical Research
- Wnt/β-catenin signaling in development and cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Erythrocyte Function and Pathophysiology
- Adipose Tissue and Metabolism
Cold Spring Harbor Laboratory
2021-2024
Queen's University
2020-2024
The Hippo pathway plays crucial roles in governing various biological processes during tumorigenesis and metastasis. Within this pathway, upstream signaling stimuli activate a core kinase cascade, involving MST1/2 LATS1/2, that subsequently phosphorylates inhibits the transcriptional co-activators YAP its paralog TAZ. This inhibition modulates regulation of downstream target genes, impacting cell proliferation, migration, death. Despite acknowledged significance protein kinases regulatory...
Gasdermin D (GSDMD) is a key executor of pyroptosis, form inflammation-induced programmed cell death. Recently, GSDMD has been shown to play important roles in the development various inflammatory-related human diseases including heart failure and cancer, suggesting that it promising therapeutic target for these diseases. While extensive studies on GSDMD's role pyroptosis have reported, challenging study its function due lack enzymatic activity GSDMD. In this study, we used NanoBiT...
The dependency of cancer cells on glucose can be targeted with high-fat low-carbohydrate ketogenic diet (KD). However, hepatic ketogenesis is suppressed in IL-6 producing cancers, which prevents the utilization this nutrient source as energy for organism. In two associated murine models cachexia we describe delayed tumor growth but accelerated onset and shortened survival when mice are fed KD. Mechanistically, find uncoupling a consequence biochemical interaction simultaneously occurring...
Abstract Metabolic rewiring is an emerging hallmark of neoplasia. In pancreatic ductal adenocarcinoma (PDAC), KRAS alters myriad metabolic programs to promote cellular transformation. Among them, the cholesterol synthesis pathway has emerged as a vulnerability cancer cells due importance in membrane fluidity and production isoprenoid intermediates that enable localization activation cancer. We recently reported non-essential gene SOAT1 (Sterol-O-Acyl transferase 1), encoding enzyme...
PURPOSE: Raman spectroscopy is an optical imaging technique used to characterize tissue via molecular analysis. The use of for real-time intraoperative classification requires fast analysis with minimal human intervention. In order have accurate predictions and classifications, a large reliable database classifications spectra results required. We developed system that can be generate efficient scanning path robotic tissues using spectroscopy. METHODS: A camera mounted controller take image...
Abstract The dependency of cancer cells on glucose can be targeted with high-fat low-carbohydrate ketogenic diet (KD). However, hepatic ketogenesis is suppressed in IL-6 producing cancers, which prevents the utilization this nutrient source as energy for organism. In two associated murine models cachexia we describe delayed tumor growth but accelerated onset and shortened survival when mice are fed KD. Mechanistically, find uncoupling a consequence biochemical interaction simultaneously...
Abstract Colorectal cancer (CRC) is one of the most common and deadly types cancer. Although recent advances in early detection revolutionary therapies such as checkpoint blockade immunotherapy resulted improved outcomes CRC, a large fraction CRC patients, particularly with metastasis, do not respond well to existing modalities. This necessitates better mechanistic understanding on tumor – immune cell interactions context CRC. Microbiome influences multiple biological aspects host including...
Abstract Immune surveillance of the intestinal epithelium is regulated by reciprocal interactions between epithelial cells, immune system and microbiome. This highly specialized compartment maintains tolerance against dietary products commensal bacteria while protecting pathogens, cancer risk tissue damage. While recent studies identified epigenetic mechanisms that orchestrate self-renewal differentiation cells (IECs), little known about govern – how they influence regeneration. Here we...
SUMMARY Overeating and a sedentary life style are major causes of obesity related metabolic disorders. Identification the neurobiological processes that regulate energy balance will facilitate development interventions for these Here we show Neurotensin-expressing neurons in mouse IPAC (IPAC Nts ), nucleus central extended amygdala, bidirectionally coordinate hedonic feeding physical activity, thereby regulating balance, bodyweight. preferentially activated by consumption highly palatable...