A5048729823- Stress Responses and Cortisol
- Neurogenesis and neuroplasticity mechanisms
- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroendocrine regulation and behavior
- Health and Lifestyle Studies
- Neonatal and fetal brain pathology
- Anesthesia and Neurotoxicity Research
- Aging, Health, and Disability
- Tryptophan and brain disorders
- Cardiac Arrest and Resuscitation
- Neuroscience and Neuropharmacology Research
- Stress and Burnout Research
- Birth, Development, and Health
- Gut microbiota and health
- Turtle Biology and Conservation
- Cholinesterase and Neurodegenerative Diseases
- Epilepsy research and treatment
- Memory and Neural Mechanisms
- Primate Behavior and Ecology
- Intensive Care Unit Cognitive Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Growth Hormone and Insulin-like Growth Factors
- Neurotransmitter Receptor Influence on Behavior
- Public Health and Social Inequalities
Mexican Social Security Institute
2016-2025
Universidad Michoacana de San Nicolás de Hidalgo
2024
University of Pittsburgh
2016-2022
Universidad Nacional Autónoma de México
2003
Early-life stress is associated with depression and metabolic abnormalities that increase the risk of cardiovascular disease diabetes. Such associations could be due to increased glucocorticoid levels. Periodic maternal separation in neonate rearing social isolation are potent stressors hypothalamus-pituitary-adrenal axis activity. Moreover, promotes feed intake body weight gain rats subjected periodic separation; however, its effects on risks have not been described. In present study, we...
Environmental enrichment (EE) confers motor and cognitive recovery in pre-clinical models of traumatic brain injury (TBI), neurogenesis has been attributed to mediating the benefits. Whether that ascription is correct not fully investigated. Hence, goal current study further clarify possible role learning-induced hippocampal on functional after cortical impact or sham by utilizing two EE paradigms (i.e., early + continuous, initiated immediately TBI presented 24 h/day; delayed abbreviated, 4...
Environmental enrichment (EE) enhances cognition after traumatic brain injury (TBI). Galantamine (GAL) is an acetylcholinesterase inhibitor that also may promote benefits. Hence, the aims of this study were to assess efficacy GAL alone (standard [STD] housing) and in combination with EE adult male rats TBI. The hypothesis was both therapies would confer motor, cognitive, histological benefits when provided singly, but their be more efficacious. Anesthetized received a controlled cortical...
Early life stress (ELS) followed by pediatric mild traumatic brain injury (mTBI) negatively impacts spatial learning and memory increases microglial activation in adolescent rats, but whether the same paradigm affects higher order executive function is not known. Hence, we utilized attentional set-shifting test (AST) to evaluate (cognitive flexibility) determine its relationship with neuroinflammation hypothalamic–pituitary–adrenal (HPA) axis activity after mTBI male rats. ELS was induced...
Abstract The presence of glia and glial glutamate transporters seems to modify glutamate‐mediated toxicity in neuronal cultures. In this work we cultured cortical cells serum‐containing medium a serum‐free (Neurobasal + B27 supplement) studied the expression GLAST, GLT, EAAC by immunocytochemistry RT‐PCR. proportion was below 10% Neurobasal 46% medium. Semiquantitative evaluation mRNA for showed similar amounts grown media. We detected immunoreactivity three both media, but coexpressed with...
Abstract Prenatal immobilization stress (PNS) and postnatal maternal separation (MS180) are two widely used rodent models of early‐life (ELS) that affect the hypothalamus–pituitary–adrenal (HPA) axis, cause behavioral alterations, glucose tolerance in adults. We compared anxiety‐like behavior, coping strategies, HPA axis activity PNS MS180 adult (4‐month‐old) male rats assessed their response after mild fasting stress. Both induced a passive strategy forced swimming test, without affecting...
Chronic early life stress (ECS) induced by limited bedding and nesting (LBN) material in rodents is a naturalistic model that mimics many of the behavioral neural consequences child abuse neglect; however, effect ECS on adult impulsivity has never been studied. The aim our work was to determine effects cognitive its relation D2 immunoreactivity nucleus accumbens (NAc) prefrontal cortex (PFC) male rats. Sprague-Dawley rats were exposed LBN from postnatal day 2 9. We evaluated dams' maternal...
Early life stress (ELS) programs hypothalamus-pituitary-adrenal (HPA) axis activity and affects synaptic plasticity cognitive performance in adults; however, the effects of ELS during temporal window vulnerability are poorly understood. This study aimed to thoroughly characterize form periodic maternal separation (MS180) time exposure stress. Hippocampal corticotropin-releasing hormone (CRH) gene expression baseline HPA were analyzed at postnatal (P) days 6, 12, 15, 21, adulthood (P75);...
Objetivo: determinar la frecuencia de experiencias infantiles adversas y su relación con presencia síntomas depresivos en una unidad medicina familiar Michoacán. Métodos: se realizó un estudio transversal analítico 139 participantes adscritos a Unidad Medicina Familiar No. 80 del Instituto Mexicano Seguro Social. Se aplicó el cuestionario internacional (ace-iq) inventario depresión Beck ii. utilizó estadística descriptiva prueba χ2. regresión logística por pasos para confirmar asociaciones....
Sea turtle egg relocation and hatchery incubation (hereafter termed ex situ incubation) is an effective strategy to protect clutches when in not viable. Nevertheless, it negatively affects the ontogenesis of male gonads brain areas homologous mammalian hippocampus, as well body size fitness. Thus, imperative analyze effects on other developmental aspects extend these observations females. This work evaluated effect management neurogenesis (cell proliferation dorsal medial ventricular zones,...