A5083662767- Celiac Disease Research and Management
- Viral gastroenteritis research and epidemiology
- Microscopic Colitis
- SARS-CoV-2 detection and testing
- T-cell and B-cell Immunology
- Acute Myeloid Leukemia Research
- Thermal Regulation in Medicine
- Neuroscience and Neural Engineering
- Thermoregulation and physiological responses
- SARS-CoV-2 and COVID-19 Research
- Protein Degradation and Inhibitors
- Planarian Biology and Electrostimulation
- Galectins and Cancer Biology
- Multiple Sclerosis Research Studies
- Drug-Induced Adverse Reactions
- 3D Printing in Biomedical Research
- Monoclonal and Polyclonal Antibodies Research
- Biosensors and Analytical Detection
- Genetic factors in colorectal cancer
- Viral Infections and Immunology Research
- Immune Cell Function and Interaction
- Blood groups and transfusion
- Epigenetics and DNA Methylation
- Salivary Gland Disorders and Functions
- Blood disorders and treatments
The University of Melbourne
2018-2024
The Royal Melbourne Hospital
2020-2024
Walter and Eliza Hall Institute of Medical Research
2016-2019
Abstract The dorsal root ganglia (DRG) consist of a multitude sensory neuronal subtypes that function to relay stimuli, including temperature, pressure, pain and position the central nervous system. Our knowledge DRG neurons have been predominantly driven by animal studies considerably less is known about human DRG. Human embryonic stem cells (hESC) are valuable resource help close this gap. previous reported an efficient system for deriving neural crest from hESC. Here we show...
Reverse transcription loop‐mediated isothermal amplification (RT‐LAMP) is a molecular method that can detect SARS‐CoV‐2 in shorter time than the current gold‐standard diagnostic reverse transcription‐polymerase chain reaction (RT‐PCR). However, previously developed RT‐LAMP assays have mostly relied on highly subjective visual colorimetric interpretation. In this study, an assay was with quantitative measurement of pH using novel portable biosensor compared to qualitative interpretation and...
Currently, the genetic variants strongly associated with risk for Multiple Sclerosis (MS) are located in Major Histocompatibility Complex. This includes DRB1*15:01 and DRB1*15:03 alleles at HLA-DRB1 locus, latter restricted to African populations; DQB1*06:02 allele HLA-DQB1 locus which is high linkage disequilibrium (LD) DRB1*15:01; protective A*02:01 HLA-A locus. HLA identification facilitated by co-inherited ('tag') single nucleotide polymorphisms (SNPs); however, SNP validation not...
Aim Voluntary dehydration, or lack of fluid intake despite water availability, is common in otherwise healthy children, and can lead to adverse effects. Most dehydration biomarkers are impractical for routine assessment paediatric populations. This study aimed assess two non‐invasive hydration tools, urine specific gravity (U SG ) a novel point‐of‐care (POC) salivary osmolarity (SOSM) sensor, children. Methods Volunteers were tested by colorimetric U handheld SOSM system. Observed values...
Coronavirus disease 2019 has highlighted deficiencies in the testing capacity of many developed countries during early stages pandemics. Here we describe a strategy using pan-family viral assays to improve accessibility large-scale nucleic acid testing.Coronaviruses and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were used as case study for assessing utility novel pandemic. Specificity pan-coronavirus (Pan-CoV) assay pathogen was assessed frequency common human (HCoV)...
Abstract Purpose Human Leukocyte Antigen (HLA) testing is useful in the clinical work-up of coeliac disease (CD), with high negative but low positive predictive value. We construct a genomic risk score (GRS) using HLA loci to improve CD prediction and guide exclusion criteria. Methods Imputed genotypes for five European case-control GWAS (n>15,000) were used validate an based models ( HDQ 15 ). Conditioning on this score, we identified novel interactions which modified risk, integrated...
Summary Background The SARS-CoV-2 pandemic has highlighted deficiencies in the testing capacity of many developed countries during early stages emerging pandemics. Here we describe potential for pan-family viral assays to improve accessibility large-scale nucleic acid testing. Methods Coronaviruses and were used as a case-study investigating utility novel pandemic. Specificity pan-coronavirus (Pan-CoV) assay detection was assessed using frequency common human coronavirus (HCoV) species key...