A5047231930- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Thyroid Cancer Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Urologic and reproductive health conditions
- Salivary Gland Tumors Diagnosis and Treatment
- Genetics, Bioinformatics, and Biomedical Research
- Ubiquitin and proteasome pathways
- Colorectal Cancer Treatments and Studies
- Thyroid and Parathyroid Surgery
- Bladder and Urothelial Cancer Treatments
- Cancer Genomics and Diagnostics
- Histone Deacetylase Inhibitors Research
- Head and Neck Surgical Oncology
- Vascular Malformations and Hemangiomas
- Sarcoma Diagnosis and Treatment
- Body Contouring and Surgery
- Head and Neck Anomalies
- Vasculitis and related conditions
- Cancer Treatment and Pharmacology
- Sinusitis and nasal conditions
- Bone Tumor Diagnosis and Treatments
- BRCA gene mutations in cancer
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
University of Virginia
2021-2024
Icahn School of Medicine at Mount Sinai
2016-2021
Mayo Clinic
2020
WinnMed
2020
State of Illinois
2020
Mayo Clinic in Arizona
2019
Université de Montréal
2013-2014
Hôpital Notre-Dame
2013-2014
Centre Hospitalier de l’Université de Montréal
2014
A novel Drosophila -based approach resulted in a significant response by patient with KRAS-mutant colorectal cancer.
Adenoid cystic carcinoma (ACC) is a rare cancer type that originates in the salivary glands. Tumors commonly invade along nerve tracks head and neck, making surgery challenging. Follow-up treatments for recurrence or metastasis including chemotherapy targeted therapies have shown limited efficacy, emphasizing need new therapies. Here, we report Drosophila-based therapeutic approach patient with advanced ACC disease. A patient-specific Drosophila transgenic line was developed to model five...
To identify social determinants of health care that are associated with poorer pediatric well-differentiated thyroid cancer (WDTC) outcomes and increased stage at presentation.Using the SEER database (Surveillance, Epidemiology, End Results), we retrospectively gathered data on WDTC across United States between 1973 2015.All patients 0 19 years old a diagnosis were included.Patient variables analyzed for relationships to AJCC presentation (American Joint Committee Cancer), overall survival,...
Objectives To assess the outcomes of abdominal dermal‐fat grafting following superficial and total parotidectomy. Methods A retrospective chart review parotidectomy patients was performed. Patients were divided into four groups based on surgical extent status: (SP), with (SPg), (TP), (TPg). Complication rates operative times then compared between surgically matched (SP vs. SPg, TP TPg). Complications included graft necrosis, gustatory sweating, first‐bite syndrome, infection, hematoma,...
Background In this study we aim to describe presenting characteristics and identify prognostic factors for disease resolution in patients with chronic rhinosinusitis (CRS) the setting of eosinophilic granulomatosis polyangiitis (EGPA). Methods Patients evaluated at a tertiary care center diagnoses EGPA CRS were identified. Descriptive statistics obtained. Univariate analysis was used search associated higher Lund‐Mackay score presentation resolution. Results Forty‐four included mean age 52.7...
Objectives/Hypothesis Use validated eye‐tracking technology to objectively measure 1) the attentional distraction of facial contour defects after superficial and total parotidectomy 2) changes in with abdominal dermal fat graft reconstruction. Methods Standardized frontal oblique images 16 patients who had undergone or without reconstruction; four normal controls were obtained. One hundred casual observers recruited view these images, gaze data collected using a Tobii Pro system. Gaze...
We examined the influence of body mass index (BMI) and fat distribution on rectal dose in patients treated with permanent seed brachytherapy for localized prostate cancer. analyzed 213 I125 BMI dosimetry data all were available. Data visceral subcutaneous at level iliac crest (n = 140) as well periprostatic symphysis pubis obtained 117). Fat was manually contoured CT day 30 after brachytherapy. The correlation between BMI, (R100 (in cc), R150 (cc), D2 (Gy)) using Spearman coefficient....
Objective The objective of this study is to describe the clinical presentation, tumor characteristics, natural history, and treatment patterns sinonasal osteosarcoma. Methods Fourteen patients who had been treated for osteosarcoma nasal cavity paranasal sinuses at a tertiary care center were reviewed. In addition, systematic review literature was performed. Results review, including 14 from authors' institution, 53 total studies 88 assessed. Median follow-up 18 months (interquartile range:...
Abstract Background Oncocytic carcinoma (OCA) was recently reclassified as a distinct differentiated thyroid (DTC). Given its rarity, OCA studies are limited. This study describes the characteristics of in 20‐year cohort. Methods Retrospective analysis patients with at single tertiary care hospital from 2000 to 2021. Results Fifty‐one (22M:29F) were identified. The mean age diagnosis 60.3 years; 90% presented palpable mass; 24% had family history cancer. None vocal fold paresis. On...
Abstract Personalized cancer genomics is providing unprecedented access into the genetic complexity and diversity of human tumors. The next challenge to utilize this information establish effective therapeutics. Functional interrogation genomes using model systems provides a powerful step towards realizing goal. To capture tumors, we identified most frequently observed double, triple quadruple combinations mutations in colon generated by TCGA. We used generate corresponding multigenic models...