A5073504999- Forensic and Genetic Research
- Carcinogens and Genotoxicity Assessment
- Yersinia bacterium, plague, ectoparasites research
- Adenosine and Purinergic Signaling
- Toxic Organic Pollutants Impact
- Archaeology and ancient environmental studies
- Genetic diversity and population structure
- Glutathione Transferases and Polymorphisms
- Asthma and respiratory diseases
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Economic Sanctions and International Relations
- Antimicrobial Peptides and Activities
- IL-33, ST2, and ILC Pathways
- Pesticide Exposure and Toxicity
- Genomics, phytochemicals, and oxidative stress
- Human Health and Disease
- Peptidase Inhibition and Analysis
- Attention Deficit Hyperactivity Disorder
- Agriculture and Biological Studies
Al-Farabi Kazakh National University
2020-2023
Institute of Plant Biology and Biotechnology
2022
Kazakh Institute of Oncology and Radiology
2021
Institute of Cytology and Genetics
2020
Institute of Animal Physiology of the Slovak Academy of Sciences
2020
Ancient genomic time-transect across the Central Asian Steppe sheds new light onto origins and demise of Scythians.
The group of persistent organic pollutants (POPs) are particularly dangerous for the environment and by consequence human health because risk to be transmitted in food chain. Among them, urgent problem obsolete forbidden organochlorinated pesticides (OCPs) needs a rigorous management many countries, including Kazakhstan. aim our study was evaluate effect content products on genetic status population living contaminated areas near destroyed warehouses OCPs (4 villages Talgar district 1...
Ethnogenesis of Kazakhs took place in Central Asia, a region high genetic and cultural diversity. Even though archaeological historical studies have shed some light on the formation modern Kazakhs, process establishment hierarchical socioeconomic structure Steppe remains contentious. In this study, we analyzed haplotype variation at 15 Y-chromosomal short-tandem-repeats obtained from 1171 individuals 24 tribes representing three socio-territorial subdivisions (Senior, Middle Junior zhuz)...
The association of genetic polymorphisms with the individual sensitivity humans to action pesticide pollution is being actively studied in world. aim this study was a molecular epidemiological analysis candidate genes involved metabolism, detoxification, and antioxidant protection. Some selected also relate susceptibility cancer cardiovascular, respiratory, immune system diseases individuals exposed pesticides for long time. For case-control unique cohort people organochlorine 10 years or...
The long-term storage of unutilized pesticides raised new problems environmental contamination. study presents the results surveying 151 individuals in 7 villages living close to pesticide-contaminated localities. All have been surveyed concerning their consumption habits and lifestyle characteristics. An assessment general exposure risks local population was carried out using analysis pollutants food products average levels region. cohort risk evaluation revealed that greatest associated...
Autism spectrum disorders (ASDs) are heterogeneous diseases that triggered by a number of environmental and genetic factors. The aim the current study was to investigate an association rs1799836 variant neurotransmitter-related gene MAOB with ASDs. In total, 262 patients diagnosed ASDs their 126 healthy siblings were included in present study. All individuals represented Kazakhstani population. distributions genotype accordance Hardy-Weinberg equilibrium among both cases controls. No...
A haplogroup is a group of similar alleles that have common ancestor in which mutationhas occurred, inherited by all descendants. Haplogroups, particularly from the Y-chromosome (Y-DNA), widely used population genetics and genetic genealogy, science studies history mankind. Recent modern Kazakhs demonstrated diversity Kazakh gene pool. During expedition carried out 2014-2016, clinical material was collected varios regions Kazakhstan, representing samples peripheral blood buccal scrapings....
All over the world, there is an active search for genes that are responsible formation of predisposition to allergic diseases, which associated both with undoubted relevance studying risk factors development allergies, and emergence new opportunities genetic research. In addition, anthropogenic impact can cause reactions modifications in functions antioxidant defense cells immune system. Due fact cohort population Almaty region (going forward we will say include also), respiratory diseases...
The study utilized molecular-genetic, cytogenetic, and statistical analyzes methods. A cytogenetic molecular genetic analysis of the inhabitants villages Amangeldy, Belbulak, in whose territory warehouses unused pesticides are located, was carried out. Residents Basshi village, on which there no products disposal pesticides, were taken as control. Cytogenetic showed a high level chromosomal aberrations for Belbulak an increased Amangeldy village low cohort. Molecular did not reveal...
Проведена оценка риска влияния многолетней пестицидной загрязненности окружающей среды на генетический статус населения, проживающего в 5 населенных пунктах Талгарского района (пп. Кызылкайрат, Бескайнар, Бельбулак, Амангельды, Енбекши) Алматинской области, где располагаются неутилизированные, запрещенные к использованию пестициды класса СОЗ. Результаты цитогенетического анализа подверженного действию пестицидов, выявили высокую частоту хромосомных аберраций, превышающую контрольные...