A5029552972- Glutathione Transferases and Polymorphisms
- Forensic and Genetic Research
- Yersinia bacterium, plague, ectoparasites research
- Genetic diversity and population structure
- Hepatitis B Virus Studies
- Epigenetics and DNA Methylation
- Bacillus and Francisella bacterial research
- Carcinogens and Genotoxicity Assessment
- Human Health and Disease
- Genetic factors in colorectal cancer
- Cancer-related Molecular Pathways
- DNA Repair Mechanisms
- Archaeology and ancient environmental studies
- Genetics and Neurodevelopmental Disorders
- Genomics and Phylogenetic Studies
- Toxic Organic Pollutants Impact
- Zoonotic diseases and public health
- Healthcare Systems and Public Health
- Hepatitis C virus research
- Peptidase Inhibition and Analysis
- Physiological and biochemical adaptations
- Sulfur Compounds in Biology
- HIV Research and Treatment
- Race, Genetics, and Society
- Glycosylation and Glycoproteins Research
Al-Farabi Kazakh National University
2022
Institute of Plant Biology and Biotechnology
2021-2022
Kazakh Institute of Oncology and Radiology
2014-2020
Institute of Cytology and Genetics
2014-2020
Ministry of Education and Science of the Republic of Kazakhstan
2013-2019
Ancient genomic time-transect across the Central Asian Steppe sheds new light onto origins and demise of Scythians.
Significance The bacterium Yersinia pestis has caused numerous historically documented outbreaks of plague and research using ancient DNA could demonstrate that it already affected human populations during the Neolithic. However, pathogen’s genetic diversity, geographic spread, transmission dynamics this early period Y. evolution are largely unexplored. Here, we describe a set genomes up to 5,000 y old from across Eurasia. Our data two genetically distinct forms evolved in parallel were both...
Aging associates with a variety of pathological conditions such as cancer, cardiovascular, neurodegenerative, autoimmune diseases, and metabolic disorders. The oncogenic alterations overlap frequently the genes linked to aging. Here, we show that several aging related may serve genetic risk factors for cervical esophagus cancers. In our study, analyzed samples obtained from 115 patients esophageal 207 cancer. control groups were selected match ethnicity age cancer patients. We examined...
This study presents the first results of a molecular-genetic colorectal cancer (CRC) in Kazakhstan. Blood samples were collected from patients diagnosed with rectal or colon (249 individuals) as well control cohort healthy volunteers (245 individuals), taking into account age, gender, ethnicity, and smoking habits CRC patients. Combined analysis data obtained individuals either Kazakh Russian decent showed significant association increased risk following genotypes: DCC (32008376G/G G/A...
The group of persistent organic pollutants (POPs) are particularly dangerous for the environment and by consequence human health because risk to be transmitted in food chain. Among them, urgent problem obsolete forbidden organochlorinated pesticides (OCPs) needs a rigorous management many countries, including Kazakhstan. aim our study was evaluate effect content products on genetic status population living contaminated areas near destroyed warehouses OCPs (4 villages Talgar district 1...
Ethnogenesis of Kazakhs took place in Central Asia, a region high genetic and cultural diversity. Even though archaeological historical studies have shed some light on the formation modern Kazakhs, process establishment hierarchical socioeconomic structure Steppe remains contentious. In this study, we analyzed haplotype variation at 15 Y-chromosomal short-tandem-repeats obtained from 1171 individuals 24 tribes representing three socio-territorial subdivisions (Senior, Middle Junior zhuz)...
The long-term storage of unutilized pesticides raised new problems environmental contamination. study presents the results surveying 151 individuals in 7 villages living close to pesticide-contaminated localities. All have been surveyed concerning their consumption habits and lifestyle characteristics. An assessment general exposure risks local population was carried out using analysis pollutants food products average levels region. cohort risk evaluation revealed that greatest associated...
Background . Glutamate cysteine ligase (GCL) is a rate-limiting enzyme in synthesis of glutathione. Evidence suggests that genetic variations the promoter region genes coding catalytic subunit (GCLC -129T/C) and modifier (GCLM -588C/T) GCL have functional impact on their transcriptional activity were associated with various disorders. Hence, we hypothesize whether these two polymorphic variants GCLM GCLC are risk ischemic heart disease (IHD) development population Kazakhstan. Methods We...
Purpose: To analyze the effects of DNA repair polymorphism and other factors on frequency chromosome aberrations in an irradiated cohort subjects living around Semipalatinsk nuclear test site non-exposed group from ecologically favorable zones Kazakhstan.Materials methods: Blood samples were collected rural areas East Kazakhstan district Almaty region Kazakhstan. Chromosome fresh cryopreserved peripheral blood lymphocyte cultures analyzed by Giemsa staining. Single nucleotide polymorphisms...
Abstract The indigenous populations of inner Eurasia, a huge geographic region covering the central Eurasian steppe and northern taiga tundra, harbor tremendous diversity in their genes, cultures languages. In this study, we report novel genome-wide data for 763 individuals from Armenia, Georgia, Kazakhstan, Moldova, Mongolia, Russia, Tajikistan, Ukraine, Uzbekistan. We furthermore two Eneolithic (∽5,400 years before present) associated with Botai culture Kazakhstan. find that are structured...
Colorectal cancer (CRC) is one of the most common types cancer, affecting 3 - 5% global population. K-ras protooncogene and TP53 tumour suppressor gene mutations are among genetic alterations detected in advanced colorectal tumours.To investigate role codon 12 exons 5 9 late-stage CRC patients.Blood samples were collected from 249 patients, whom 147 presented with carcinoma. analysed using polymerase chain reaction-restriction fragment length polymorphism, while direct sequencing was used...
The study of extended pedigrees containing autism spectrum disorder- (ASD-) related broader phenotypes (BAP) offers a promising approach to the search for ASD candidate variants. Here, total 650,000 genetic markers were tested in four Kazakhstani multiplex families with and BAP obtain data on de novo mutations (DNMs), common, rare inherited variants that may contribute risk developing autistic traits. analyzed context gene networks pathways. Several previously well-described enriched...
Here, we show that several aging related genes may serve as the genetic risk factors for cervical, esophagus and colorectal cancers. We examined involved in processes of xenobiotics detoxification (GSTM1 GSTT1), DNA repair (XRCC1, XRCC3, hMLH1), cell cycle regulation apoptosis (CCND1, TP53, DCC). The study results will lead to development screening detection individuals susceptible esophageal, cervical Introduction programs allow early effective preventive measures reduce cancer incidence...
Aim.To investigate correlation between nitric oxide synthase, heat shock protein Hsp70 and apoptosis regulatory gene grim in D. melanogaster.Methods.The stress (37 °C for 1 hour) induction third instar larvae of Oregon R strain transgenic strains, containing additional copies dNOS1 gene.RT-PCR Western-blot analysis were used to study the expression dNOS, genes.Results.It is demonstrated that strains are intensively expressed immediately after induction.It was revealed all Drosophila level...
It is believed that DNA damaging toxic metabolites contributes to the development of different pathological conditions. To prevent harmful influence agents, cells developed number protecting mechanisms, such as enzymatic reaction detoxification reactive and repair damage. The aim study was examine association between polymorphism GSTT1/GSTM1 XRCC1/3 genes coronary artery disease (CAD) incidence. a these in CAD susceptibility patients controls, PCR based genotyping assay performed. For GST...
A haplogroup is a group of similar alleles that have common ancestor in which mutationhas occurred, inherited by all descendants. Haplogroups, particularly from the Y-chromosome (Y-DNA), widely used population genetics and genetic genealogy, science studies history mankind. Recent modern Kazakhs demonstrated diversity Kazakh gene pool. During expedition carried out 2014-2016, clinical material was collected varios regions Kazakhstan, representing samples peripheral blood buccal scrapings....
Epilepsy is a common manifestation of mitochondrial disorders, in addition oxidative stress may play an important role epileptogenesis since it affects the excitability neurons. Mitochondrial diseases are often difficult to diagnose unless symptoms clearly identified as part specific mutation. The use next-generation sequencing would lead rapid identification genes associated with epilepsy syndromes. In this study, we evaluate applicability NGS method for diagnosis by clinicians and...
Б а с р е д к т о НҰРҒОЖИН Талғат Сейітжанұлы, медицина ғылымдарының докторы, профессор, ҚР ҰҒА корреспондент мүшесі (Алматы, Қазақстан) H = 10 РЕДАКЦИЯ АЛҚАСЫ: БЕРСІМБАЕВ Рахметқажы Ескендірұлы (бас редактордың орынбасары), биология академигі