Electrochemiluminescence (ECL) is a highly successful technique used in commercial immunoassays for clinical diagnosis. Developing an ECL-based multiplex immunoassay, with the potential to enable high-throughput detection of multiple biomarkers simultaneously, remains current research interest yet limited by narrow choice ECL luminophores. Herein we report synthesis, photophysics, electrochemistry, and several new ruthenium(II) iridium(III) complexes, three which are eventually as signal...

Copolymer hybrid films consisting of polypyrrole/MoSx (x ≈ 5) with significantly enhanced electrocatalytic activity for the hydrogen evolution reaction (HER) are fabricated by a one-step electrochemical copolymerization pyrrole and (NH4)2MoS4. The show Tafel slope 29 mV dec−1 an onset potential 0 V vs. RHE, which is comparable to those commercial Pt/C catalysts. As service our authors readers, this journal provides supporting information supplied authors. Such materials peer reviewed may be...

An electrochemical DNAzyme sensor for sensitive and selective detection of lead ion (Pb2+) has been developed, taking advantage catalytic reactions a upon its binding to Pb2+ the use DNA−Au bio-bar codes achieve signal enhancement. A specific is immobilized onto an Au electrode surface via thiol−Au interaction. The hybridizes specially designed complementary substrate strand that overhang, which in turn code (short oligonucleotides attached 13 nm gold nanoparticles). redox mediator,...

Nanometer-sized glass-sealed metal ultramicroelectrodes (UMEs) have been prepared using a laser-based micropipet puller. The tip was exposed to solution either by etching away small portion of glass insulator or micropolishing. characterization the UMEs carried out combination steady-state voltammetry, scanning electron microscopy (SEM), and electrochemical (SECM). cyclic voltammograms obtained regular shape with very capacitive resistive background. effective electrode radii from...

A layered MoS2–thionin composite was prepared by sonicating their mixture in an ionic liquid and gradient centrifugation. Because DNA is rarely present single-stranded form, either naturally or after PCR amplification, the used for fabrication of a double-stranded (dsDNA) electrochemical biosensor due to stable response, intercalation, electrostatic interaction thionin with DNA. The linear range over dsDNA concentration from 0.09 ng mL–1 1.9 obtained, moreover, it suitable detection (ssDNA)....

A series of novel bimetallic PtCu nanochains have been synthesized through a water-based mild chemical route, and their compositions (PtxCu1–x) can be conveniently tuned at the mesoscopic scale by facile dealloying process. These nanomaterials characterized transmission electron microscope (TEM), high-resolution TEM (HRTEM), X-ray powder diffraction (XRD), elemental analysis. They different (Pt88Cu12, Pt75Cu25, Pt50Cu50) but similar morphology. Electrochemical activity these is compared to...

The electrocatalytic activity of commercial MoP microparticles for hydrogen evolution reaction was enhanced by grinding and potentiostaticly electrochemical activation.

A simple strategy for one-step fabrication of tris(bipyridine)ruthenium(II) (Ru(bpy)32+)-functionalized metal–organic framework (Ru-MOF) thin films using a self-assembly approach assisted by an electrochemical way was introduced. In this protocol, the electrochemically driven cooperative reaction Ru(bpy)32+ as electrochemiluminescent (ECL) probe and structure-directing agent, trimesic acid (H3btc) ligand, Zn(NO3)2 Zn2+ source leads to simultaneous synthesis deposition MOF onto electrode...

Abstract To have a profound understanding of the physiological and pathological processes in brain, both chemical electrical signals need to be recorded, but this is still very challenging. Herein, micrometer‐ nanometer‐sized SERS optophysiological probes were created determine CO 3 2− concentration pH live brains neurons because species play important roles regulating acid–base balance brain. A ratiometric microarray eight microprobes with tip sizes 5 μm was established used for first time...

Molecular catalysis of water oxidation has been intensively investigated, but its mechanism is still not yet fully understood. This study aims at capturing and identifying key short-lived intermediates directly during the catalyzed by a cobalt-tetraamido macrocyclic ligand complex using newly developed an in situ electrochemical mass spectrometry (EC-MS) method. Two ligand-centered-oxidation intermediates, [(L2–)CoIIIOH] [(L2–)CoIIIOOH], were observed for first time, further confirmed...

A new way of using the scanning electrochemical microscope (SECM) to probe ion transfer (IT) reactivity liquid/liquid and liquid/membrane interfaces is described. micropipet filled with solvent (e.g., water) immiscible outer solution organic) serves as an SECM tip. The tip current due between pipet solution. When such a approaches macroscopic or interface, IT process depletes concentration transferred near phase boundary. If second another aqueous solution) contains same ion, depletion...

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTFast Kinetic Measurements with Nanometer-Sized Pipets. Transfer of Potassium Ion from Water into Dichloroethane Facilitated by Dibenzo-18-crown-6Yuanhua Shao and Michael V. MirkinView Author Information Department Chemistry Biochemistry Queens CollegeCUNY, Flushing, New York 11367 Cite this: J. Am. Chem. Soc. 1997, 119, 34, 8103–8104Publication Date (Web):August 27, 1997Publication History Received4 June 1997Published online27 August inissue...

Affinity chromatographic assays for thrombin were developed using two aptamers as affinity ligands. The efficient capture and step elution of with NaClO4 enabled the determination by either absorbance or fluorescence detection. Preconcentration on column improved detection limit to 0.1 nM. Using an aptamer fibrinogen-binding site a second heparin-binding site, sandwich assay was developed, showing selectivity eliminating need labeling in sample. increased local concentration immobilized...

Keeping up: The fastest kinetic data for ion transfer at a liquid/liquid interface were evaluated by nanopipette voltammetry. steady-state voltammograms can be explained theoretical models. In previous electrochemical measurements the systematic underestimation of k0 is probably result inefficient mass to relatively large interface. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made...

A hybrid microelectrode can connect MS and electrochemical reactions, providing direct information on products or intermediates to identify the reaction mechanisms with easy use low cost.

The modification of glass nanopipettes with polyethyleneimines (PEIs) has been successfully achieved by a relatively simple method, and the smallest tip opening is around 3 nm. Thus, in much wider range pipettes radii from several nanometers to few micrometers, ion current rectification (ICR) phenomenon observed. influences different KCl concentrations, pH values, on ICR are investigated detail. sizes PEIs have determined dynamic light scattering, effect for modification, especially...

This review summarizes progress in the fabrication, modification, characterization, and applications of nanopipettes since 2010. A brief history is introduced, details characterization are provided. Applications chemical analysis focus several cases, including recent imaging; study single molecules, nanoparticles, cells; fundamental investigations charge transfer (ion electron) reactions at liquid/liquid interfaces; as hyphenated techniques combined with other methods to mechanisms...

The lithium-sulfur (Li-S) battery is one of the most promising next generation energy storage systems due to its high theoretical specific energy. However, shuttle effect soluble lithium polysulfides formed during cell operation a crucial reason for low cyclability suffered by current Li-S batteries. As result, an in-depth mechanistic understanding sulfur cathode redox reactions urgently required further advancement Herein, direct observation in reported situ hyphenated technique...

The use of micropipet electrodes for quantitative voltammetric measurements ion-transfer (IT) and electron-transfer (ET) reactions at the interface between two immiscible electrolyte solutions (ITIES) requires knowledge geometry liquid interface. shape meniscus formed pipet tip was studied in situ by video microscopy under controlled pressure. can be changed from a complete sphere to concave spherical cap varying pressure applied pipet, diffusion current changes accordingly. With no external...

The numerical integration of the differential equation for cyclic voltammetry has been performed case where reverse potential is set prior to forward peak potential. A working curve stemming from these integrations allows determination half-wave species limiting window. This technique applied measurement formal Gibbs energies transfer ions across water/1,2-dichloroethane interface. validity TATB (tetraphenylarsonium tetraphenylborate) assumption also discussed.