A5079381511- Pharmacogenetics and Drug Metabolism
- Hormonal and reproductive studies
- Metabolomics and Mass Spectrometry Studies
- Isotope Analysis in Ecology
- Hormonal Regulation and Hypertension
- Insect and Arachnid Ecology and Behavior
- Mass Spectrometry Techniques and Applications
- Birth, Development, and Health
- Estrogen and related hormone effects
- Insect and Pesticide Research
- Forest Insect Ecology and Management
- Analytical Chemistry and Chromatography
- Microbial Community Ecology and Physiology
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Eicosanoids and Hypertension Pharmacology
Max Planck Institute for Marine Microbiology
2024
Melbourne Genomics Health Alliance
2024
The University of Melbourne
2024
Australian National University
2018-2022
The study of urinary phase II sulfate metabolites is central to understanding the role and fate endogenous exogenous compounds in biological systems. This describes a new workflow for untargeted metabolic profiling sulfated urine matrix. Analysis was performed using ultra-high-performance liquid chromatography-high resolution tandem mass spectrometry (UHPLC-HRMS/MS) with data dependent acquisition (DDA) coupled an automated script-based processing pipeline differential metabolite level...
The steroid disulfates ( aka bis-sulfates) are a significant but minor fraction of the urinary metabolome that have not been widely studied because major components hydrolyzed by commercial sulfatases commonly used in metabolomics. In early studies, conjugate fractionation followed hydrolysis using acidified solvent (solvolysis) was for indirect detection this GC–MS. This paper describes application specific LC–MS/MS method direct identification urine, and their use as markers prenatal...
The identification and confirmation of steroid sulfate metabolites in biological samples are essential to various fields, including anti-doping analysis clinical sciences. Ultra-high-performance liquid chromatography with tandem mass spectrometry (UHPLC-MS/MS) is the leading method for detection intact conjugates biofluids, but because inherent complexity low concentration many targets interest, metabolite based solely on remains a major challenge. new typically depends comparison...
Reliable drywood termite detection in structures is challenging but critical for effective management. A microwave-based non-destructive method was evaluated detecting activity. This study factors affecting the ability of this device to reliably detect Cryptotermes brevis timber. The displayed a high probability successfully C. naturally infested boards. system detected termites 97% time when used at highest sensitivity level, while producing few false positives. number did not affect...
Abstract The ability to spatially measure multi-modal data provides an unprecedented opportunity comprehensively explore molecular regulation at transcriptional, translational and metabolic levels acquire insights on cellular activities underpinning health disease. However, there is currently a lack of analytical tools integrate complementary information across different spatial-omics modalities, particularly with respect spatial metabolomics data, which becoming increasingly invaluable. We...
Carbohydrates are fundamental molecules of life and involved in virtually all biological processes. The chemical diversity glycans – carbohydrate chains enables these diverse functions, but also challenges analytics. Mass spectrometry (MS) is a powerful approach to resolve identify glycan structures. Annotation MS data relies heavily on experimental databases or manual calculations, hindering the discovery novel compositions Here, we introduce Glyco- Annotate - package open-source...
Steroid bis(sulfate) metabolites derived from the two-fold sulfation of unconjugated precursors represent an important yet understudied portion steroid profile. The investigation these compounds in fields such as medicine or anti-doping science relies on mass spectrometry (MS) principal tool to identify and quantify biomarkers interest depends turn access reference materials their stable isotope labelled (SIL) derivatives. A new [18O] label for sulfate is reported, which allows selective,...