A5050130353- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Diabetes and associated disorders
- T-cell and B-cell Immunology
- Neonatal Respiratory Health Research
- Vasculitis and related conditions
- Cell Adhesion Molecules Research
- Infant Nutrition and Health
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammatory Bowel Disease
- Gastrointestinal motility and disorders
- Immune responses and vaccinations
- Essential Oils and Antimicrobial Activity
- Digestive system and related health
University Medical Center Hamburg-Eppendorf
2017-2021
Universität Hamburg
2017-2021
Although it is well established that microbial infections predispose to autoimmune diseases, the underlying mechanisms remain poorly understood. After infection, tissue-resident memory T (TRM) cells persist in peripheral organs and provide immune protection against reinfection. However, whether TRM participate responses unrelated primary such as inflammation, unknown. By using high-dimensional single-cell analysis, we identified CD4+ with a TH17 signature (termed TRM17 cells) kidneys of...
IL-6 is required for the response of mice against Listeria monocytogenes. Control infection depends on classical signaling via membrane IL-6Rα, but target cells and protective mechanisms remain unclear. We used with IL-6Rα-deficiency in T (Il6rafl/fl×CD4cre) or myeloid (Il6rafl/fl×LysMcre) to define role these IL-6-mediated protection. Abrogation IL-6Rα did not interfere bacteria control induction TH1 CD8+ T-cell responses. caused significant defects listeria control. This defect was...
Prenatal glucocorticoids are routinely administered to pregnant women at risk of preterm delivery in order improve survival the newborn. However, half cases, birth occurs outside beneficial period for lung development. Glucocorticoids potent immune modulators and cause apoptotic death immature T cells, we have previously shown that prenatal betamethasone treatment doses eliciting maturation induce profound thymocyte apoptosis offspring. Here, asked if there long-term consequences on...
The adaptive immune response and IL-17A contribute to renal damage in several experimental models of injury.
Anti-glomerular basement membrane (anti-GBM) disease is characterized by antibodies and T cells directed against the Goodpasture antigen, noncollagenous domain of α3-chain type IV collagen [α3(IV)NC1] GBM. Consequences are deposition autoantibodies along GBM development crescentic glomerulonephritis (GN) with rapid loss renal function. Forkhead box protein P3 (Foxp3)+ regulatory (Treg) crucial for maintenance peripheral tolerance to self-antigens prevention immunopathology. Here, we use...