A5037359960- Education, Healthcare and Sociology Research
- Schizophrenia research and treatment
- Research in Social Sciences
- Social and Educational Sciences
- European and International Law Studies
- Bipolar Disorder and Treatment
- Pharmaceutical Practices and Patient Outcomes
- Healthcare Systems and Challenges
- Pharmacogenetics and Drug Metabolism
- Health and Medical Studies
- Pharmaceutical studies and practices
- Psychiatric care and mental health services
- Empathy and Medical Education
- COVID-19 and Mental Health
- Electroconvulsive Therapy Studies
- Italian Fascism and Post-war Society
- Healthcare Systems and Technology
- Historical Influence and Diplomacy
- Pharmacological Effects and Toxicity Studies
- Blood Pressure and Hypertension Studies
- Pharmacovigilance and Adverse Drug Reactions
- Mental Health and Psychiatry
- Health, psychology, and well-being
- Music Therapy and Health
- Renewable Energy and Sustainability
Diakonhjemmet Hospital
2013-2025
Sykehuset i Vestfold
2020-2022
Norwegian Medical Association
2019
Haraldsplass Diakonale Sykehus
2016-2017
University of Oslo
2014-2015
Background: Antipsychotic medications are commonly prescribed for older patients; however, documentation on their safety and efficacy in this population is limited. This study aimed to investigate compare the effect of age dose-adjusted serum concentrations 6 used antipsychotic both sexes. Methods: Patients with concentration measurements amisulpride, aripiprazole, clozapine, olanzapine, risperidone, zuclopenthixol were retrospectively included from a therapeutic drug monitoring service. The...
Valproic acid (VPA) is frequently used with clozapine (CLZ) as mood stabilizer and/or seizure prophylaxis. known to reduce N-desmethylclozapine (N-DMC) but not CLZ levels. This leads the hypothesis that VPA induces metabolism via non-N-desmethylation pathways. Therefore, we aimed investigate effect of concurrent use on serum concentrations a spectrum metabolites in patients, adjusting for smoking.In total, 288 patients an overall number 737 concentration measurements and concurrently using...
Objectives This survey assessed psychiatry residents'/early-career psychiatrists' attitudes towards the utility of therapeutic drug monitoring (TDM) antipsychotics.
Olanzapine is a commonly prescribed antipsychotic available as oral and long-acting injectable (LAI) formulations. Data are lacking on the use safety of olanzapine-LAI in older patients. The aim this study was to investigate effect increasing age olanzapine exposure during versus LAI administration real-life setting.This observational based routine therapeutic drug monitoring data collected 2005-2017. As measure exposure, absolute concentrations concentration/dose ratios were defined outcome...
Aims To investigate the effect of aging, sex and cytochrome P450 (CYP) genotypes on exposure quetiapine (QUE) pharmacologically active metabolite N ‐desalkylquetiapine (NDQ). Methods Patients with serum concentrations QUE NDQ were included retrospectively from a therapeutic drug monitoring service. The outcome measures concentration:dose (C:D) ratios NDQ, NDQ:QUE metabolic ratio. Linear mixed model analyses used to evaluate effects age, and, subsequently, CYP2D6/3A genotypes. Results average...
The combination of olanzapine and valproic acid (VPA) is regularly prescribed in the treatment bipolar or schizoaffective disorders. VPA has been shown to reduce concentration, but mechanism behind this interaction remains unknown. We aimed investigate effect on concentration during oral versus long-acting injectable (LAI) formulation a real-life setting.From therapeutic drug monitoring service, doses serum concentrations from 2791 olanzapine-treated patients (9433 measurements) were...
Previous studies have shown cognitive impairment in long-term benzodiazepine users compared to non-users. However, little is known about such effects a population of geriatric psychiatry patients. The aim this study was identify differences between and non-users on standardized tests the fields learning memory, executive functions vigilance, at admittance department psychiatry. Hopkins verbal test, Stroop test digit vigilance were performed all Test performances (n=168) (n=73). A multiple...
Polypharmacy is common among older persons who are also vulnerable to side effects. We aimed characterize patients on admission a geriatric psychiatric hospital had major medication effects interfering with daily performance.Cross-sectional cohort study of consecutively admitted from 2006, 06 December 2008, 24 October. The UKU effect rating scale was performed, and were divided into those no/minor versus Blood levels 56 psychotropic drugs 27 safety laboratory tests measured upon admission.Of...
Glucuronidation is an important metabolic pathway of clozapine (CLZ), but the impact various uridine 5'diphospho-glucuronosyltransferases (UGT) polymorphisms on exposure and metabolism CLZ in vivo unclear.The objective this study was to investigate UGT2B haplotype UGT1A4*3 allele variants formation glucuronide metabolites (5N- N+-glucuronide) patients' serum after adjusting for sex, age smoking habits.The based samples from CLZ-treated patients (n=79) subjected routine therapeutic drug...
<b>Introduction:</b> The aim of this study was to investigate cognitive functions after admission a geriatric psychiatric hospital, and the short-term effects cessation benzodiazepine use on functions. <b>Methods:</b> Details serum concentration measurements were recorded admission. Hopkins verbal learning test, Stroop Digit Vigilance Test Mini Mental Status Examination performed admission, 4 weeks hospitalization. results compared for total group patients, as well “continuers” “quitters”....
It is generally agreed that prescribing of antipsychotic drugs to older patients should be reduced, but figures for the these living at home in Norway are not available. The study aimed investigate developments among from 2006 2018, and whether there were differences rates between age groups 65-74 years, 75-84 years 85 or older.Data retrieved Norwegian Prescription Database. All persons aged 65 who dispensed least one drug 2006, 2010, 2014 2018 included, gender-specific prevalence ten most...
08.09.2015: Intervju - Da hodejegeren spurte daværende direktør ved Radiumhospitalet om hva han hadde bruk for, svarte Jan Vincents Johannessen: «Gode folk!» Dermed fikk politimannen Per Bleikelia, som etter en lang skole i helsevesenet er blitt populær sykehusdirektør.
11.02.2014: Intervju - Hva er et leveår verdt? Er vi sykere enn før eller bare mer sykmeldt? Samfunnsmedisiner Ivar Sønbø Kristiansen liker debatt og synes ikke det noen motsetning mellom tall, etikk empati.
12.02.2009: Intervjuet - Den kommende generalsekretæren i Legeforeningen har utsikt over hele Oslo fra toppen av det som tidligere het Postgirobygget og kan kikke til sin nye arbeidsplass Akersgata.
Background: Older people are particularly vulnerable to critical or fatal illness as a result of infection with the corona virus and have been encouraged selfisolate during pandemic.The importance screen-based media telephones tools help prevent loneliness, maintain contact friends family, ensure necessary follow-up by healthcare services has highlighted.However, knowledge about how older used screenbased pandemic lacking. Objective:The objective study was examine over age 70 for purposes...