A5058033893- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Hydrogels: synthesis, properties, applications
- Memory and Neural Mechanisms
- Additive Manufacturing and 3D Printing Technologies
- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Nerve injury and regeneration
- Innovative Microfluidic and Catalytic Techniques Innovation
- bioluminescence and chemiluminescence research
- EEG and Brain-Computer Interfaces
- Olfactory and Sensory Function Studies
- Spinal Cord Injury Research
- Tissue Engineering and Regenerative Medicine
- Neurological disorders and treatments
- Spaceflight effects on biology
- Hemostasis and retained surgical items
- Advanced Chemical Sensor Technologies
- Polymer Surface Interaction Studies
- Bacterial biofilms and quorum sensing
- Terahertz technology and applications
- Thermochemical Biomass Conversion Processes
- Molecular Communication and Nanonetworks
South China University of Technology
2024
University of Chinese Academy of Sciences
2020-2024
State Key Laboratory of Transducer Technology
2021-2024
Chinese Academy of Sciences
2020-2024
Aerospace Information Research Institute
2020-2024
Wuhan Textile University
2021-2024
Key Laboratory of Guangdong Province
2019
Southeast University
2016
Accurate detection of the degree isoflurane anesthesia during a surgery is important to avoid risk overdose timely. To address this challenge, four-shank implantable microelectrode array (MEA) was fabricated for synchronous real-time dual-mode signals [electrophysiological signal and dopamine (DA) concentration] in rat striatum. The SWCNTs/PEDOT:PSS nanocomposites were modified onto MEAs, which significantly improved electrical electrochemical performances MEAs. performance MEAs with low...
Hyaluronic acid (HA) hydrogel is preferred for biomedicine applications, as it possesses biodegradability, biocompatibility, and cell-regulated capacity well high hydration nature similar to the native extracellular matrix. However, HA fabricated via a 3D printing technique often faces poor properties. In this study, maleiated sodium hyaluronate (MHA) with substituted degree of acrylate group (i.e., 2.27) thiolated (SHHA) were synthesized. By blending these modified HAs, MHA/SHHA hydrogels...
Abstract Microscale fibrous materials with high surface areas and ordered structures have attracted widespread attention recently. Microfluidic spinning technology that can effectively control the sizes, structures, material compositions of fibers has emerged as a robust approach for fabrication high‐performance fibers. In this review, microfluidic used to prepare in terms preparation principles geometric configurations is presented. Additionally, several applications spun by technology,...
Precise and directional couplings of functional nanomaterials with implantable microelectrode arrays (IMEAs) are critical for the manufacture sensitive enzyme-based electrochemical neural sensors. However, there is a gap between microscale IMEA conventional bioconjugation techniques enzyme immobilization, which leads to series challenges such as limited sensitivity, signal crosstalk, high detection voltage. Here, we developed novel method using carboxylated graphene oxide (cGO) directionally...
Threatened animals respond with appropriate defensive behaviors to survive. It has been accepted that midbrain periaqueductal gray (PAG) plays an essential role in the circuitry system and organizes behavioral responses. However, correlation of different PAG subregions expression remain largely unexplored. Here, we designed manufactured a microelectrode array (MEA) simultaneously detect activities dPAG vPAG neurons freely behaving rats. To improve detection performance MEAs, PtNP/PEDOT:PSS...
Defense is the basic survival mechanism of animals when facing dangers. Previous studies have shown that midbrain periaqueduct gray (PAG) was essential for production defense responses. However, correlation between endogenous neuronal activities dorsal PAG (dPAG) and different behaviors still unclear. In this article, we designed manufactured microelectrode arrays (MEAs) whose detection sites were arranged to match shape position dPAG in rats, modified it with platinum-black nanoparticles...
The medial amygdala (MA) plays an important role in the innate fear circuit. However, electrophysiological mechanism of MA for processing needs to be further explored. In this study, we fabricated microelectrode arrays (MEAs) with detecting sites arranged match location and shape mice detected electrophysiology freely behaving under 2-methyl-2-thiazoline (2MT)-induced fear. detection performance MEA is improved by modifying metal nanoparticles conductive polymers (PtNPs/PEDOT:PSS). After...
Grid cells with stable hexagonal firing patterns in the medial entorhinal cortex (MEC) carry vital function of serving as a metric for surrounding environment. Whether this mechanism processes only spatial information or involves nonspatial remains elusive. Here, we fabricated an MEC-shaped microelectrode array (MEA) to detect variation neural spikes and local field potentials MEC when rats forage square enclosure planar, three-dimensional object social landmarks sequence. The results showed...
Epilepsy severely impairs the cognitive behavior of patients. It remains unclear whether epilepsy-induced impairment is associated with neuronal activities in medial entorhinal cortex (MEC), a region known for its involvement spatial cognition. To explore this neural mechanism, we recorded spikes and local field potentials from MEC neurons lithium-pilocarpine-induced epileptic rats using self-designed microelectrode arrays. Through open test, identified cells exhibiting spatially selective...
Neural information transmission between deep brain nuclei and the cortex is essential for function. Currently, high-resolution simultaneous detection of neural large-scale still poses challenges. We have developed microelectrode arrays based on Micro-Electro-Mechanical System technology, modified electrode surface with nanomaterials to improve performance. This study combined extended-field-of-view microscopy achieve recording claustrum (CLA) electrophysiology wide-field cortical calcium...
The electrophysiological activities of head direction (HD) cells under visual and vestibular input dissociation are important to understanding the formation sense in animals. In this paper, we fabricated a PtNPs/PEDOT:PSS-modified MEA detect changes discharge HD dissociated sensory conditions. electrode shape was customized for retrosplenial cortex (RSC) conducive sequential detection neurons at different depths vivo when combined with microdriver. recording sites were modified...
Timely monitoring of anesthesia status during surgery is important to prevent an overdose isoflurane anesthesia. Therefore, in-depth studies the neural mechanisms anesthetics are warranted. Hippocampal CA1 plays role Currently, a high spatiotemporal resolution microdevice technology for accurate detection deep brain nuclei lacking. In this research, four-shank 32-channel implantable microelectrode arrays (MEAs) were developed real-time recording single-cell level information in rat...
The detection of neuroelectrophysiology while performing optogenetic modulation can provide more reliable and useful information for neural research. In this study, an optical fiber a microelectrode array were integrated through hot-melt adhesive bonding, which combined optogenetics electrophysiological technology to achieve neuromodulation neuronal activity recording. We carried out the experiments on activation infected neurons at depth range 900–1250 μm in brain covers hippocampal CA1...