Bedrettin ORHAN

ORCID: 0000-0003-3970-2344
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Chronic Lymphocytic Leukemia Research
  • Lymphoma Diagnosis and Treatment
  • Acute Myeloid Leukemia Research
  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Viral-associated cancers and disorders
  • Neutropenia and Cancer Infections
  • Acute Lymphoblastic Leukemia research
  • Hematopoietic Stem Cell Transplantation
  • CNS Lymphoma Diagnosis and Treatment
  • Urinary Bladder and Prostate Research
  • Platelet Disorders and Treatments
  • Dermatological and COVID-19 studies
  • Urinary Tract Infections Management
  • Blood disorders and treatments
  • Histiocytic Disorders and Treatments
  • Diet and metabolism studies
  • Fungal Infections and Studies
  • Diverticular Disease and Complications
  • Glioma Diagnosis and Treatment
  • Blood groups and transfusion
  • Bone and Joint Diseases
  • Complement system in diseases
  • Chronic Myeloid Leukemia Treatments
  • Multiple Myeloma Research and Treatments
  • Cutaneous lymphoproliferative disorders research

Bursa Uludağ Üni̇versi̇tesi̇
2021-2025

Adli Tıp Kurumu
2021

Fırat University
2017-2018

Bursa Technical University
2018

Fırat Üniversitesi Hastanesi
2017

Hacettepe University
2010

Ankara University
2008

Aims: It was aimed at measuring the comorbidities of chronic myeloid leukemia (CML) patients time diagnosis with different comorbidity indices and evaluating their effects on disease prognosis. Methods: The were retrospectively screened calculated in three indices: ACE-27 Comorbidity Index, Age-adjusted Charlson Elixhauser Index. C-statistic used to evaluate ability discriminate mortality. relationship between scores overall survival (OS) evaluated Kaplan-Meier curve. Mortality risk analyzed...

10.1177/20406207251323701 article EN cc-by-nc Therapeutic Advances in Hematology 2025-01-01

Myelodysplastic syndrome (MDS) is a clonal hematopoietic stem cell disease. Supportive treatments, such as erythropoiesis-stimulating agents (ESAs), are commonly used in patients with low-risk MDS. This study aimed to retrospectively assess the impact of bone marrow Mothers against decapentaplegic homolog 7 (SMAD-7) and Transforming Growth Factor Beta 1 (TGF-β1) protein expression on prognosis response ESA treatment We analyzed diagnosed MDS at adult hematology department Bursa Uludağ...

10.17305/bb.2025.11564 article EN cc-by Biomolecules and Biomedicine 2025-03-03

Abstract The impact of inflammatory markers such as systemic immune-inflammation (SII) index and inflammation response (SIRI) on myelofibrosis (MF) prognosis was evaluated for the first time in this study. Data from 60 patients diagnosed with MF between March 2011 September 2022 were retrospectively analyzed. In addition to disease-related markers, SII SIRI evaluated. our study, overall median survival (OS) 64 months. OS significantly shorter older than 65 years, high ferritin lymphocyte...

10.1038/s41598-023-39077-7 article EN cc-by Scientific Reports 2023-08-02

Infections are the most common cause of anal and perianal pathologies in patients with hematological malignancies. Perianal infection diagnosis this group is difficult; thus, a careful anorectal examination necessary imaging modalities. In addition, literature reveals knowledge gap approach to neutropenia during or chemotherapy. This study aimed examine our institutional data on complications investigate relationship between white blood cell-neutrophil count, lesion, type treatment...

10.4084/mjhid.2022.051 article EN cc-by-nc Mediterranean Journal of Hematology and Infectious Diseases 2022-06-29

Kaposi sarcoma is a rare disease and there gap in the literature about which chemotherapeutics should be applied, especially for classical type. We aimed to present our institutional data on demographic characteristics, treatment, treatment efficacy 16 (KS) patients treated with chemotherapy. retrospectively analyzed clinical chemotherapeutic agents administered KS diagnosed center chemotherapy, based medical records obtained. The median age, gender, type of KS, site involvement, cytotoxic...

10.17305/bjbms.2020.5329 article EN Bosnian Journal of Basic Medical Sciences 2021-02-12

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)

10.1530/endoabs.37.ep446 article EN Endocrine Abstracts 2015-05-01

Turkish Stem Cell Coordination Center (TURKOK) carries out the procurement process of unrelated allogeneic hematopoietic stem cells in Turkey. This study aims to compare efficacy both once-daily and divided-dose G-CSF administration original biosimilar use frequency severity adverse events TURKOK donors.The was conducted retrospectively with 142 healthy donors. For PBSC mobilization, two different subcutaneous programs were used as 10 μ/kg/day single-dose 5 μ/kg/12 h. Neupogen (Amgen, Puerto...

10.1002/jca.21995 article EN Journal of Clinical Apheresis 2022-06-11

Acute lymphoblastic leukemia (ALL) is an aggressive hematologic malignancy of lymphoid progenitor cells. During treatment ALL, the patients may be complicated by fatal infections such as sinonasal mucormycosis. In with immunocompromised conditions like haematologic malignancies, mucormycosis can deadly. Once has been detected, it critical to act quickly begin treatment. Amphotericin B, posaconazole, or isavuconazole are medications choice. Effective requires a long-term course therapy....

10.46310/tjim.1316471 article EN cc-by-nc-nd Turkish Journal of Internal Medicine 2024-01-21

Thrombotic thrombocytopenic purpura (TTP) is a life-threatening occlusive disease of the microcirculation characterized by systemic platelet plugs, organ ischemia, deep thrombocytopenia, and fragmentation erythrocytes. One widely used scoring system to determine clinical probability TTP PLASMIC system. This study aimed evaluate contribution score modifications sensitivity specificity in patients with microangiopathic hemolytic anemia (MAHA) undergoing plasma exchange prediagnosis at our...

10.1111/ijlh.14115 article EN International Journal of Laboratory Hematology 2023-06-13

Objective: The aim of this study is to determine antibacterial susceptibilities Gram-negative bacteria isolated from diabetic and non-diabetic patients as infectious agents community-acquired urinary tract infections (UTI) compare their rates resistance the antibiotics frequently used in empirical treatment. Methods: Ninety-six sixty-eight (total n=164) patients’ data were evaluated retrospectively who diagnosed system infection consulted outpatient clinics Department Endocrinology...

10.5798/dicletip.474694 article EN Dicle Medical Journal / Dicle Tip Dergisi 2018-10-25

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)

10.1530/endoabs.49.ep249 article EN Endocrine Abstracts 2017-05-03

Our study investigated leukapheresis's effect on delayed induction therapy outcomes in patients with acute leukemia presenting symptomatic hyperleukocytosis.This retrospective cohort included 30 adult diagnosed who underwent leukapheresis for leukostasis. The were divided into the first 24 h and >24 groups, according to time from diagnosis (TDT).There was no significant difference between TDT groups regarding complete remission (CR), 4-week mortality, overall survival (OS) at a median...

10.1111/1744-9987.13990 article EN Therapeutic Apheresis and Dialysis 2023-04-11

İlk oral proteazom inhibitörü (PI) olan iksazomib, lenalidomid ve deksametazon (IRd) ile kombinasyon halinde relaps refrakter multipl miyelomun (RRMM) tedavisi için onaylanmıştır. Bununla birlikte, klinik çalışma sonuçları her zaman gerçek dünyadaki sonuçlarla örtüşmez. Bu çalışmanın amacı, yaşamda RRMM'li hastaların iksazomib bazlı tedavisinin sonuçlarını değerlendirmektir. Çalışmaya Bursa Uludağ Üniversitesi Tıp Fakültesi Hematoloji Bilim Dalı’ndan toplam 45 RRMM tanılı hasta retrospektif...

10.32708/uutfd.1249696 article TR Uludağ Üniversitesi Tıp Fakültesi Dergisi 2023-04-20

Background Hairy cell leukemia (HCL) is an uncommon neoplasm representing approximately 2% leukemias and

10.46310/tjim.1239905 article EN cc-by-nc-nd Turkish Journal of Internal Medicine 2023-04-29

Background: Dapsone is a second-line therapy for immune thrombocytopenia (ITP). It cost-effective, with response rate comparable to other drugs used as therapy, such azathioprine, danazol, cyclophosphamide, cyclosporine, vincristine, rituximab, and eltrombopag.
 Material Methods: This retrospective study analyzed ten adult patients who presented our hematology division outpatient clinic between March 2013 July 2021, was diagnosed chronic/refractory ITP, did not respond first-line...

10.46310/tjim.1211506 article EN cc-by-nc-nd Turkish Journal of Internal Medicine 2023-04-29
Coming Soon ...