A5015350422- Tendon Structure and Treatment
- Muscle Physiology and Disorders
- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Sports injuries and prevention
- Cellular Mechanics and Interactions
- Tissue Engineering and Regenerative Medicine
- Genetic Neurodegenerative Diseases
- Shoulder Injury and Treatment
- Laser Applications in Dentistry and Medicine
- Orthopedic Surgery and Rehabilitation
- Muscle metabolism and nutrition
- Genetics and Neurodevelopmental Disorders
- T-cell and Retrovirus Studies
- Nuts composition and effects
- Muscle activation and electromyography studies
- Myofascial pain diagnosis and treatment
- Mesenchymal stem cell research
- Hippo pathway signaling and YAP/TAZ
- Knee injuries and reconstruction techniques
Inserm
2015-2024
Sorbonne Université
2015-2024
Centre de Recherche en Myologie
2021-2024
Laboratoire de Biologie du Développement
2016-2024
Institut de Myologie
2024
Centre National de la Recherche Scientifique
2015-2020
Institut de Biologie Paris-Seine
2019-2020
Université Paris Cité
2015-2016
Adaptation Biologique et Vieillissement
2016
Physiologie et Médecine Expérimentale du Coeur et des Muscles
2016
Background Tendon is a mechanical tissue that transmits forces generated by muscle to bone in order allow body motion. The molecular pathways sense during tendon formation, homeostasis and repair are not known. EGR1 mechanosensitive transcription factor involved repair. We hypothesized senses signals promote gene expression. Methodology/Principal findings Using vitro vivo models, we show the expression of Egr1 genes downregulated 3D-engineered tendons made mesenchymal stem cells when tension...
The elaboration of biomimetic materials inspired from the specific structure native bone is one main goal tissue engineering approaches. To offer most appropriate environment for reconstruction, we combined electrospinning and electrospraying to elaborate an innovative scaffold composed alternating layers polycaprolactone (PCL) hydroxyapatite (HA). In our approach, electrospun PCL was shaped into a honeycomb-like with inner diameter 160 μm, capable providing cells 3D while ensuring material...
The differentiation potential of mesenchymal stem cells (MSC) has been extensively tested on electrospun scaffolds. However, this is often assessed with lineage-specific medium, making it difficult to interpret the real contribution properties scaffold in cell response. In study, we analyzed ability different polycaprolactone/polylactic acid PCL/PLA scaffolds (pure or blended compositions, random aligned fibers, various fiber diameters) drive MSC towards bone tendon lineages absence specific...
ABSTRACT Background Exercise is widely considered to have beneficial impact on skeletal muscle aging. In addition, there are also several studies demonstrating a positive effect of exercise muscular dystrophies. Oculopharyngeal dystrophy (OPMD) late-onset autosomal dominant inherited neuromuscular disorder caused by mutations in the PAPBN1 gene. These consist short (1-8) and meiotically stable GCN trinucleotide repeat expansions its coding region responsible for formation intranuclear...
Exercise is widely considered to have beneficial impact on skeletal muscle aging. In addition, there are also several studies demonstrating a positive effect of exercise muscular dystrophies. Oculopharyngeal dystrophy (OPMD) late-onset autosomal dominant inherited neuromuscular disorder caused by mutations in the PAPBN1 gene. These consist short (1-8) and meiotically stable GCN trinucleotide repeat expansions its coding region responsible for formation intranuclear aggregates. This study...
One of the main challenges in tendon field relies understanding regulators differentiation program. The optimum culture conditions that favor cell are not identified. Mesenchymal stem cells present ability to differentiate into multiple lineages cultures under different cues ranging from chemical treatment physical constraints. We analyzed potential C3H10T1/2 cells, a murine line mesenchymal upon 2D- and 3D-culture conditions. observed cultured 2D on silicone substrate were more prone...
Abstract Tendons are composed of type I collagen fibrils and specialized extracellular matrix (ECM) proteins that hierarchically organized to transmit forces from muscle bone. Reliable affordable models human tendon constructs requested serve surgical treatment after injury in vitro pharmacological testing. Here, using adipose stromal cells embedded a 3D type-I submitted static uniaxial geometrical constraint, we generated assessed their mechanical properties gene expression for up 21 days...
Abstract One of the main challenges in tendon field relies understanding regulators differentiation program. The optimum culture conditions that favor cell are not identified. Mesenchymal stem cells present ability to differentiate into multiple lineages cultures under different cues ranging from chemical treatment physical constraints. We analyzed potential C3H10T1/2 cells, a murine line mesenchymal upon 2D- and 3D-culture conditions. observed cultured 2D on silicone substrate were more...
Event Abstract Back to No Records Found Login Required This action requires you be registered with Frontiers and logged in. To register or login click here. Info The Authors in Google Scholar PubMed Related Article Close top Javascript is disabled. Please enable your browser settings order see all the content on this page.