A5080876843- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Gallbladder and Bile Duct Disorders
- Gastrointestinal disorders and treatments
- Gastric Cancer Management and Outcomes
- IgG4-Related and Inflammatory Diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal and GI Pathology
- Neuroblastoma Research and Treatments
- Gastrointestinal Tumor Research and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Microscopic Colitis
- Gastrointestinal Bleeding Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Liver Disease Diagnosis and Treatment
- Blood transfusion and management
- Vitamin D Research Studies
- Hidradenitis Suppurativa and Treatments
- Viral-associated cancers and disorders
- Ultrasound Imaging and Elastography
- Lymphoma Diagnosis and Treatment
Hiroshima University Hospital
2019-2024
Hiroshima University
2019-2024
Onomichi General Hospital
2014-2019
Abstract Background and study aims Few studies have evaluated detection of pancreatic carcinoma in situ (PCIS). We findings endoscopic ultrasound (EUS) pathological features PCIS. Patients methods histopathologically studied 16 patients with PCIS following EUS. Diagnostic retrospectively included stricture the main duct (MPD) on EUS, presence or absence hypoechoic areas surrounding MPD noncancerous part (pancreas background) EUS histopathology, histological adjacent to area Results On was...
Early diagnosis of pancreatic ductal adenocarcinoma (PDAC) is challenging but essential for improving its poor prognosis. We established a multicenter study to clarify the clinicopathological features, and propose new algorithm early PDAC. Ninety-six patients with stage 0 IA PDAC were enrolled from 13 high-volume centers. Overall, 70% asymptomatic. The serum enzyme levels abnormal in half patients. sensitivity endoscopic ultrasonography (EUS) detecting small was superior computed tomography...
Pathological examination is essential for the diagnosis and treatment of pancreatic ductal adenocarcinoma (PDAC). Moreover, a reliable pathological extremely important improving prognosis, especially in early-stage PDAC. This study prospectively evaluated usefulness repeated juice cytology (PJC) using an endoscopic nasopancreatic drainage (ENPD) catheter We enrolled 82 patients suspected having resectable PDAC, based on imaging studies, judged necessity cytology. The diagnostic yield up to...
Most patients with pancreatic cancer (PC) demonstrate recurrences in the form of metastatic disease. We prospectively evaluated recurrence PC cases diagnosed at an early stage.Thirty stage 0 or IA were followed for least 1 year after initial surgery. performed blood tests and contrast-enhanced computed tomography (CT) every 3 to 6 months. Endoscopic ultrasonography (EUS) was if CT revealed abnormal findings remnant pancreas (RP).The median follow-up period 53.9 Pancreatic recurred RP (n = 8)...
Objectives This study aimed to evaluate the pathological features and imaging findings of pancreatic carcinoma in situ (PCIS). Methods Twenty patients with PCIS were categorized as flat (F) (n = 6) low papillary (LP) 14) types. Results None F type 8 (57%) 14 LP lesions showed intraductal infiltrations main duct (MPD) greater than 10 mm. 3 (21%) skip MPD. Magnetic resonance cholangiopancreatography irregular MPD stenoses 5 (83%) 6 13 (100%) lesions. determined that median lengths 3.6 mm for...
A 69-year-old man with advanced non-small-cell lung cancer was treated pembrolizumab for 4 months. Three months after discontinued, computed tomography showed enlargement of the pancreatic head, hypoattenuating areas in head to body. On endoscopic ultrasonography, entire parenchyma hypoechoic. Endoscopic retrograde cholangiopancreatography narrowing main duct at head. ultrasound-guided fine-needle aspiration inflammatory cell infiltration stroma but no neoplastic lesions. CD8-positve T cells...
膵癌の予後は不良であるが,膵上皮内癌の段階で診断できれば,予後は良好である.我々は膵癌早期診断を目指した地域連携プロジェクトを展開している.その結果,2007年1月から2015年12月の期間において膵上皮内癌を17例診断し得た.これらの臨床的特徴について検討を行った.男女比は10:7,部位は頭部4例,体部13例.MRCPでは17例全例で主膵管の限局的狭窄または分枝膵管拡張を認めた.EUSでは,16例で主膵管狭窄を認め,そのうち8例で狭窄周囲低エコー,3例で低エコー腫瘤を認めた.20mmの腫瘤を認めた1例でEUS-FNAを施行したが陰性であった.ERCPは全例で施行し,全例で膵液を採取,13例はENPD留置下複数回膵液細胞診(SPACE)を行い膵液を採取した.膵液細胞診全体の感度は76.5%,SPACEでは84.6%と良好な成績であった.膵上皮内癌の診断にはMRCPおよびEUSでの主膵管狭窄や分枝膵管拡張,狭窄周囲低エコーに着目し,SPACEを行うことが必要である.
Objectives This study aimed to investigate the utility of fluorodeoxyglucose (FDG) positron emission tomography for solid pseudopapillary neoplasm (SPN) diagnosis. Methods The subjects included 53 cases SPN. We compared maximal standardized uptake volume (SUVmax) with those 25 pancreatic duct cancer and 18 neuroendocrine neoplasm. In addition, immunopathological testing SPN regard FDG was undertaken. Results An increase in SUVmax observed all tumors increased tumor diameter. Among 20 mm or...
PNENの病理組織学的分化度と各種画像所見の関連性を明らかにするため,当院で経験したPNEN症例をWHO2017分類に基づき高分化型(NET G1/G2/G3)と低分化型(NEC G3)に分類し,それぞれにおける画像所見を比較検討した.画像診断にて典型的所見のみを認めた症例はすべて高分化型であり,特にNET G1で多かった.非典型的所見のうち,早期濃染なし/不整形はNET G3,NEC G3で多く認められ,高悪性度を示唆する所見と考えられた.石灰化/嚢胞形成はNET G1,G2のみに認められ,高分化を示唆する所見と考えられた.PET-CT陽性率は悪性度の上昇に伴い増加しており,低分化型で有意に陽性率が高かったが,SUVmax値は高分化型と低分化型で有意差を認めなかった.画像所見とPNEN悪性度には関連性が認められ,画像診断により,ある程度の悪性度の診断予測が可能であることが示唆された.しかしNET G3とNEC G3の鑑別は画像所見のみでは困難であり,画像診断に加えて十分な病理組織学的検討が必要である.
Abstract Gastric duplication cyst (GDC) is a rare gastrointestinal malformation that frequently occurs in the greater curvature of gastric antrum or corpus. Herein, we reported case intrapancreatic GDC found as result recurring pancreatitis. A 15-year-old man experienced repeated episodes acute pancreatitis and was to have cystic lesion pancreatic tail. Contrast-enhanced computed tomography revealed 20-mm with an enhanced thick wall. Endoscopic ultrasonography anechoic three-layered Magnetic...
A 74-year-old man with obstructive jaundice presented a thickened distal bile duct wall. transpapillary forceps biopsy revealed an adenocarcinoma; however, because the tumor image was different from that of typical cholangiocarcinoma, endoscopic ultrasound-guided fine-needle aspiration performed on and enlarged lymph nodes. The cells were positive for synaptophysin CD56 Ki67 labeling index 95%, he diagnosed small cell neuroendocrine carcinoma. We carcinoma component node metastasis....
Differential diagnosis of isolated immunoglobin (Ig)G4-related sclerosing cholangitis (IgG4-SC) and cholangiocarcinoma is challenging. We aimed to clarify the role endoscopic retrograde cholangiography (ERCP)-related procedures in differential IgG4-SC perihilar (PHCC).
Abstract Background/Purpose A recent study has demonstrated that the timing of endoscopic ultrasound‐guided fine needle aspiration (EUS‐FNA) significantly influences peritoneal lavage cytology (CY) outcomes in pancreatic body‐tail cancer. The aim this was to clarify impact EUS‐FNA on CY positivity patients with resectable Methods Patients anatomically cancer surgically resected at Hiroshima University Hospital were enrolled, and elated clinicopathological factors, including variables rate,...
膵腫瘤を形成せず,膵管異常所見が診断の契機となることの多い早期の膵癌を病理学的に診断するためには,内視鏡的逆行性胆管膵管造影(endoscopic retrograde cholangiopancreatography:ERCP)による細胞診が必要である.内視鏡的経鼻膵管ドレナージカテーテルを留置して複数回膵液細胞診を提出する手法は,SPACE(serial pancreatic juice aspiration cytologic examination)と呼ばれ,上皮内癌や小膵癌の病理学的診断において優れた成績が報告されている.診断的ERCPによる急性膵炎のリスクは決して低くないが,長期予後の期待できる早期の膵癌の確定診断にERCP下細胞診,特にSPACEの果たす役割は大きい.
A 70-year-old woman presented to our hospital with abdominal pain. Imaging examinations showed diffuse and extensive wall thickening at the perihilar bile duct; however, degree of stricture was mild, mucosal epithelium smooth. transpapillary biopsy performed considering cholangiocarcinoma IgG4 sclerosing cholangitis as differential diagnoses; no pathologic diagnosis obtained. Peroral cholangioscopy revealed a regular stricture, endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA)...
<b><i>Background:</i></b> The PillCam® patency capsule (PPC) was developed to minimize the risk of retention during endoscopy (CE). Typically, use capsules prior CE requires patients be monitored over a period time. To reduce need for frequent outpatient visits PPC examination and CE, we overnight (ON-CE) procedure. <b><i>Methods:</i></b> Between October 2012 January 2014, total 19 (15 males 4 females, mean age 48.4 years) were administered...
Type 1 autoimmune pancreatitis responds well to glucocorticoid therapy with a high remission rate. Moreover, maintenance can help prevent relapse. However, the relapse rate following cessation of long-term is unknown. The aim this study was clarify and predictors cessation.We analyzed 94 patients who achieved after undergoing therapy, discontinued treatment at least 6 months were subsequently followed up for months. divided into three groups based on duration (< 18, 18-36, ≥ 36 months),...