A5058827648- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthetic Organic Chemistry Methods
- Asymmetric Synthesis and Catalysis
- Advanced Synthetic Organic Chemistry
- Chemical synthesis and alkaloids
- Spinal Fractures and Fixation Techniques
- Chemical Synthesis and Analysis
- Alkaloids: synthesis and pharmacology
- Musculoskeletal pain and rehabilitation
- Synthesis and Catalytic Reactions
- Radical Photochemical Reactions
- Spine and Intervertebral Disc Pathology
- Image Processing and 3D Reconstruction
- Phytochemistry and Bioactive Compounds
- Chemical Reactions and Mechanisms
- Cancer Treatment and Pharmacology
- Education, Psychology, and Social Research
- Fluorine in Organic Chemistry
- Transport and Logistics Innovations
- Cyclopropane Reaction Mechanisms
- Cervical and Thoracic Myelopathy
- Tracheal and airway disorders
- Esophageal and GI Pathology
- Vehicle emissions and performance
University of Oxford
2020-2023
Na Homolce Hospital
2023
Masaryk University
2015-2022
Yale University
2018
Herein, we describe the convergent enantioselective total synthesis of himalensine A in 18 steps, enabled by a highly enantio- and diastereoselective construction morphan core via palladium/hydroxy proline co-catalyzed desymmetrization vinyl-bromide-tethered cyclohexanones. The reaction pathway was illuminated density functional theory calculations, which support an intramolecular Heck situ-generated enamine intermediate, where exquisite enantioselectivity arises from carboxylate...
We report the catalytic asymmetric synthesis of Tafluprost (1), a prostaglandin analogue. This demonstrates new approach to prostaglandins involving symmetrization and desymmetrization racemic precursor control absolute relative stereochemistry cyclopentyl core. Key steps include diastereo- enantioselective Rh-catalyzed Suzuki–Miyaura reaction bicyclic allyl chloride an alkenyl boronic acid regio- diastereoselective Pd-catalyzed Tsuji–Trost with enolate surrogate.
Antibiotics derived from the diterpene fungal metabolite (+)-pleuromutilin (1) are useful agents for treatment Gram-positive infections in humans and farm animals. Pleuromutilins elicit slow rates of resistance development minimal cross-resistance with existing antibiotics. Despite efforts aimed at producing new derivatives by semisynthesis, modification tricyclic core is underexplored, part due to a limited number functional group handles. Herein, we report methods selectively functionalize...
Abstract A 24‐step synthesis of (±)‐forskolin is presented, which delivered hundred milligram quantities this complex diterpene in one pass. Transformations key to our approach include: a) a strategic allylic transposition, b) stepwise assembly sterically encumbered isoxazole ring, and c) citric acid‐modified Upjohn dihydroxylation resilient tetrasubstituted olefin. The developed route has exciting potential for the preparation new forskolin analogues inaccessible by semisynthesis.
We report a new synthetic strategy for the flexible preparation of forskolin-like molecules. The approach is different from previously published works and employs convergent assembly tricyclic labdane-type core pre-functionalized cyclic building blocks. Stereoselective Michael addition enabled fragment coupling with excellent control over three newly created contiguous stereocenters, all-carbon quaternary centers included. Silyl enol ether-promoted ring-opening metathesis paired ring closure...
PURPOSE OF THE STUDY This article presents the evidence and rationale for recommendations surgical treatment of degenerative lumbar stenosis (DLS) spondylolisthesis that were recently developed as a part Czech Clinical Practice Guideline (CPG) "The Surgical Treatment Degenerative Diseases Spine". MATERIAL AND METHODS The was drawn up in line with National Methodology CPG Development, which is based on Grading Recommendations, Assessment, Development Evaluation (GRADE) approach. We used an...
Abstract A 24‐step synthesis of (±)‐forskolin is presented, which delivered hundred milligram quantities this complex diterpene in one pass. Transformations key to our approach include: a) a strategic allylic transposition, b) stepwise assembly sterically encumbered isoxazole ring, and c) citric acid‐modified Upjohn dihydroxylation resilient tetrasubstituted olefin. The developed route has exciting potential for the preparation new forskolin analogues inaccessible by semisynthesis.
Abstract The base‐induced rearrangement of substrate (I) is believed to involve an oxirane intermediate.