Purpose: To correlate outflow function and tract vessel diameter changes induced by nitric oxide (NO). Methods: In a porcine anterior segment perfusion model, the effects of donor (100 μM DETA-NO) on facility were compared with controls (n = 8 per group) trabecular meshwork (TM) after circumferential ab interno trabeculectomy (AIT). Outflow structures assessed spectral-domain optical coherence tomography (SD-OCT) before NO, or an NO synthase inhibitor L-NAME) vasoconstrictor, endothelin-1...

The most important etiologic agent in the pathogenesis of cervical cancers (CCs) is human papillomavirus (HPV), while mechanisms underlying are still not well known. Glucose-6-phosphate dehydrogenase (G6PD) reported to elevate various tumor cells. However, no available references elucidated correlation between levels G6PD and HPV-infected CC until now. In present study, we explored possible role pathology induced by HPV infection. Totally 48 patients with + another 63 healthy women enrolled...

Purpose To investigate the outcomes and complications of suture pull-through insertion techniques for Descemet stripping automated endothelial keratoplasty (DSAEK) in Chinese phakic eyes. Patients Methods Retrospective case series. Included study were all patients with eyes who underwent DSAEK at Peking University Third Hospital from August 2008 to 2011. All ocular diseases recorded. Distance visual acuity (DVA), near (NVA), intraocular pressure (IOP), anterior chamber depth (ACD), central...

AIM: To compare the corneal biomechanical properties difference by ocular response analyzer (ORA) in normal tension glaucoma (NTG) patients with different visual field (VF) progression speed. METHODS: NTG well-controlled Goldmann applanation tonometer (GAT) who routinely consulted Kitasato University Hospital Glaucoma Department between January 2010 and February 2014 were enrolled. GAT ORA parameters including compensated intraocular pressure (IOPcc), estimated (IOPg), hysteresis (CH),...

Purpose To investigate whether microsurgical excision of trabecular meshwork (TM) in an ex vivo pigmentary glaucoma model can normalize the hypertensive phenotype. Methods Eight eyes a porcine underwent 90° TM with aspirating dual-blade (Goniotome (G)). 24 hours later, additional were removed. Anterior segments sham surgeries served as control (C). Outflow facility and intraocular pressure (IOP) analyzed. Histology hematoxylin eosin (H&E) was obtained. Results After first excision, IOP...

Mature megakaryocytes (MKs) are large cells, having an approximate diameter in humans of 20–40 μm. They develop from CD34+ multipotent hematopoietic progenitors through a complex differentiation process driven primarily by the hormone thrombopoietin (TPO) (reviewed refs. 1,2). The cellular hierarchy megakaryocytic lineage comprises three types cells (3,4): MK progenitors, immature MKs or promegakaryoblasts, and mature (Fig. 1). (HPP-CFU, BFU CFU Fig. 1; see caption for definitions)...

Abstract Background Aniridia is a rare eye disorder with high incidence of glaucoma, and surgical intervention often needed to control the intraocular pressure (IOP). Here, we reported case illuminated microcatheter-assisted circumferential trabeculotomy (MAT) performed on an aniridic glaucoma patient following previous failed angle surgery. The procedures for were also reviewed. Case presentation A 21-year-old man, diagnosed came our hospital consulting poor left eye’s IOP despite receiving...

To investigate the effects of Ripasudil (K-115), a Rho-kinase inhibitor, in porcine model pigmentary glaucoma.In vitro trabecular meshwork (TM) cells and ex vivo perfused eyes were subjected to pigment dispersion followed by K-115 treatment (PK115). PK115 was compared controls (C) (P). Cytoskeletal alterations assessed F-actin labeling. TM cell phagocytosis fluorescent targets evaluated flow cytometry. Cell migration studied with wound-healing assay. Intraocular pressure continuously...

Purpose: To investigate the relationship between retinal microvasculature changes and intraocular pressure (IOP) for ocular hypertension (OHT) patients further assess factors associated with microcirculation changes. Methods: This was a single-center prospective study designed OHT patients, which consisted of two visits. After collecting baseline data those who met eligibility criteria, these were treated latanoprost 0.005% ophthalmic solution 4 weeks. Peripapillary vessel density (VD)...

To study the possible mechanism and treatment for pigment dispersion glaucoma (PDG) caused by single-piece acrylic (SPA) intraocular lens (IOL) ciliary sulcus fixation in Asian eyes.Patients referred PDG SPA IOL to our hospital from April 2005 June 2011 were included. The patients' general information, type, interval between initial surgery occurrence, examination findings, antiglaucoma medicine regimen surgical interventions recorded.In total, six eyes five Chinese patients included this...

To investigate in vivo confocal microscopy (IVCM) findings patients with Posner-Schlossman Syndrome (PSS), we compared the IVCM from eyes of with: PSS (44 eyes); herpes simplex keratitis (HSK) (45 HLA-B27 anterior uveitis (B27AU) and acute attack primary angle closure (aPAC) (43 eyes). The central Langerhans cells (LCs) grade at level corneal basal epithelial group (2.33 ± 0.55) was similar to that HSK (2.63 0.67) (χ2 = -1.435, P 0.174) but significantly higher than those B27AU (1.80 0.79)...

To evaluate the efficiency and safety of micropulse laser trabeculoplasty (MLT) for primary open angle glaucoma (POAG) patients.Retrospective study. POAG patients undergoing MLT in Peking University Third Hospital from June 2016 to November 2017. Seventy-two eyes 72 were enrolled. Only one eye each patient was treated by MLT. The intraocular pressure (IOP) before at 1d, 1, 4, 12 24wk medication after treatment compared.The IOP 20.6±5.9 mm Hg 20.8±6.8 2h MTL. 17.9±4.4, 18.0±4.3, 17.5±3.4,...

The aim of the study was to evaluate long-term safety and efficacy Trabectome for Chinese glaucoma patients.

Trabeculectomy is the most efficient surgical treatment. Prevention failure of bleb cicatrix would lead to unsatisfactory postoperative intraocular pressure (IOP) controlling and success rate. The aim this study was evaluate 5-year outcomes trabeculectomy with a cross-linked sodium hyaluronate gel implantation for Chinese glaucoma patients.This prospective, case-controlled study. Patients who were be applied first-time in Department Ophthalmology Peking University Third Hospital between 2010...

There are various endoscopic techniques for thyroid carcinoma dissection but few reports regarding the scarless neck technique and central compartment (CCD) via breast approach, especially bilateral CCD available. In this study, we reported 45 cases with total or near-total thyroidectomy plus approach.

To evaluate the 2-year efficacy and safety of ab interno trabeculectomy with Trabectome in Chinese primary open-angle glaucoma (POAG) patients. This was a multicenter, retrospective study included POAG patients or without visually-significant cataracts. The outcome intraocular pressure (IOP) reduction. Secondary outcomes reduction medications, surgical complications, success at 2-years. Success defined as: 1) IOP < 21 mmHg least 20% from baseline after 3 months any two consecutive...