A5002717200- Fungal Infections and Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Mosquito-borne diseases and control
- Extracellular vesicles in disease
- Antifungal resistance and susceptibility
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Metabolism, Diabetes, and Cancer
- Pancreatic and Hepatic Oncology Research
- Molecular Biology Techniques and Applications
- Inflammasome and immune disorders
- Irrigation Practices and Water Management
- Viral Infections and Vectors
- Long-Term Effects of COVID-19
- Immune cells in cancer
- Cancer Research and Treatments
- Turfgrass Adaptation and Management
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Actinomycetales infections and treatment
- Soil and Unsaturated Flow
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Olfactory and Sensory Function Studies
Lawrence Livermore National Laboratory
2022-2025
San Joaquin Valley Agricultural Sciences Center
2021
Agricultural Research Service
2021
California State University, Fresno
2020
Cognitive impairment is one of the many symptoms reported by individuals suffering from long-COVID and other post-viral infection disorders such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). A common factor among these conditions a sustained immune response increased levels inflammatory cytokines. Tumor necrosis alpha (TNF-α) interleukin-6 (IL-6) are two cytokines that elevated in patients diagnosed with ME/CFS. In this study, we characterized changes neural functionality,...
Abstract Coccidioidomycosis, or Valley fever, is an emerging respiratory disease caused by soil dwelling fungi of the Coccidioides genus that expected to spread from southwest into central U.S. 2050. While 60% infections are asymptomatic, other 40% patients experience a range symptoms, self-limiting pneumonia life-threatening disseminated disease. The immunological events underlie progression severe remain under defined. Here, we probed early immune response using high dose attenuated strain...
Abstract Coccidioidomycosis, or Valley Fever, is a lung disease caused by inhalation of Coccidioides fungi, prevalent in the Southwestern U.S., Mexico, and parts Central South America. 350,000 cases are reported annually although that number expected to increase as climate change expands fungal geographic range. While 60% infections asymptomatic, symptomatic 40% often misdiagnosed due similarities with bronchitis pneumonia. A small subset infection progress severe illness, necessitating...
ABSTRACT Coccidioidomycosis, or Valley fever, is a lung disease caused by inhalation of Coccidioides fungi, prevalent in the Southwestern United States, Mexico, and parts Central South America. Annually, States reports 10,000–20,000 cases, although those numbers are expected to increase as climate change expands fungal geographic range. While 60% infections asymptomatic, 40% symptomatic often misdiagnosed due similarities with bronchitis pneumonia. A small subset infection progress severe...
Neurotropic alphaviruses such as Venezuelan equine encephalitis virus (VEEV) are critical human pathogens that continually expand to naïve populations and for which there no licensed vaccines or therapeutics. VEEV is highly infectious via the aerosol route a recognized weaponizable biothreat causes neurological disease in humans. The neuropathology of has been attributed an inflammatory immune response brain yet underlying mechanisms specific cell involved not fully elucidated. This study...
Pancreatic ductal adenocarcinoma (PDAC) is one of the top five deadliest forms cancer with very few treatment options. The 5-year survival rate for PDAC 10% following diagnosis. Cadherin 11 (Cdh11), a cell-to-cell adhesion molecule, has been suggested to promote tumor growth and immunosuppression in PDAC, Cdh11 inhibition significantly extended mice PDAC. However, mechanisms by which deficiency influences progression anti-tumor immune responses have yet be fully elucidated. To investigate...
Abstract Triple-negative breast cancer (TNBC) comprises 20% of cases and exhibits an aggressive phenotype with increased metastasis; these patients have limited treatment options, poorer prognosis higher mortality than other cancers (BC). Metallomics is a relatively new discipline that studies the abundance metal ions in biological samples. Metallomic analysis has identified differences BC elements such as iron (Fe) zinc (Zn) but it unclear if reflect metabolic changes tumor. In this study,...
Abstract Lung cancer has a high incidence rate and is the main cause of cancer-related deaths with 127,070 fatalities expected in U.S. this year. Non-small cell lung (NSCLC) accounts for an estimated 85% all cases typically diagnosed at advanced disease stage, where outcomes are often poor treatment options limited. Targeted therapies only available to minority NSCLC patients identifiable tumor-driving mutations. Anti-programmed death protein 1 (anti-PD-1) immunotherapy become first-line...
Abstract Neurotropic alphaviruses such as Venezuelan equine encephalitis virus (VEEV) are critical human pathogens that continually expand to naïve populations and for which there no licensed vaccines or therapeutics. VEEV is highly infectious via the aerosol route a recognized weaponizable biothreat causes neurological disease in humans. The neuropathology of has been attributed an inflammatory immune response brain yet underlying mechanisms specific cell involved not fully elucidated. This...
Abstract Non-small cell lung cancer (NSCLC) patients exhibit minimal symptoms until late-stage disease, resulting in approximately 80% of being diagnosed at advanced stages when the response to therapy is low. Effective pre-clinical models are needed accurately reflect NSCLC disease progression and improve basic research. This work characterizes two genetically engineered mouse (GEMM) that human NSCLC. These lines utilize a cre recombinase system induce expression oncogenic mutations...
Human epidermal growth factor receptor 2 (HER2)‐positive breast cancer represents about 20% of cases and although treatments are available, some patients develop resistance to multiple exposures anti‐HER2 therapies. New strategies need be developed for a more accurate selection who can benefit from these treatments. While much is known HER2 biology, the biochemical impact on cell metabolism not well understood. The goal this project better understand metabolomics associated molecular...
Abstract Lung cancer is the second most diagnosed type of and leading cause cancer-related deaths in both men women. An estimated 235,760 new cases lung 131,880 are expected this year accounting for 12% 22% United States. Exosomes secreted vesicles that contain selectively packaged biomaterials (protein, lipids, RNA) serve as a form extracellular communication between cells tumor microenvironment. Previous studies have shown effects cancer-derived exosomes on specific cell types or gross...