A5101983630- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiovascular and exercise physiology
- Cardiac Health and Mental Health
- Cardiac Structural Anomalies and Repair
- Cancer-related molecular mechanisms research
- RNA regulation and disease
- Cardiac Arrhythmias and Treatments
- Infective Endocarditis Diagnosis and Management
- Circular RNAs in diseases
- Cardiovascular Disease and Adiposity
- Heart Rate Variability and Autonomic Control
- Elasticity and Material Modeling
- Cell Adhesion Molecules Research
- Radiation Dose and Imaging
- Diabetes Treatment and Management
- Advanced MRI Techniques and Applications
- Innovative Teaching Methods
- Aortic Disease and Treatment Approaches
- Pleural and Pulmonary Diseases
- Transplantation: Methods and Outcomes
- Problem and Project Based Learning
- Systemic Lupus Erythematosus Research
- Occupational and environmental lung diseases
Beijing Tsinghua Chang Gung Hospital
2020-2024
Tsinghua University
2020-2023
First Hospital of China Medical University
2012-2023
Jinzhou Medical University
2023
Lanzhou University
2019-2022
Lanzhou University Second Hospital
2019-2022
China Medical University
2012-2020
Alfred Health
2012
Activation of EGFR is a major risk factor for non-small cell lung cancer (NSCLC). Understanding the molecular events promoting activation can help us gain more insights into progression NSCLC. In this study, we demonstrate that collagen type VIII alpha 1 chain (COL8A1), an extracellular matrix component, was overexpressed in NSCLC cells, knockdown COL8A1 suppressed growth, cycle progression, and migration, induced apoptosis. While overexpression promoted proliferation inhibited addition,...
Palmitic acid (PA) can induce lipotoxic damage to cardiomyocytes, although its precise mechanism of action has not been completely elucidated. Growth arrest‑specific transcript 5 (GAS5) is a long noncoding RNA that serves regulatory role in several pathological processes, including tumorigenesis, stroke, cardiac fibrosis and osteoarthritis; however, PA‑induced myocardial injury remains elusive. The present study aimed explore the underlying GAS5 on injury. expression PA‑treated...
To explore the beneficial effects and underlying mechanisms of aerobic exercise on chronic heart failure (CHF).A CHF rat model was induced via left anterior descending coronary artery ligation. Four weeks post-surgery, rats received training over an 8-week period cardiac function indexes including xxx were analyzed. investigate involved in exercise-induced benefits CHF, overexpression long non-coding RNA MALAT1 examined both vivo vitro. Furthermore, interaction between microRNA miR-150-5p...
Abstract Background Cardiac function varies in different ways ischemic heart disease (IHD). We aimed to evaluate the characteristics of cardiac on cardiopulmonary exercise test (CPET) IHD with coronary stenoses. Methods Totally 614 patients were divided into non-obstructive artery (NOCAD) (stenosis < 50%), obstructive (OCAD) 50-90%) and severe OCAD ( stenosis > 90%) according angiography. And 101 healthy volunteers as controls. All participants performed CPET assess by oxygen uptake...
Ivabradine is an effective treatment for focal atrial tachycardia. However, it may also be re-entrant arrhythmia. An 85-year-old woman with a history of underlying ischaemic cardiomyopathy complained worsening symptoms heart failure because rapid tachycardia that was resistant to several rate-controlling drugs, but responded well ivabradine. electrophysiology study demonstrated roof-dependent macro-re-entrant the left atrium. Linear ablation roof resulted in termination Thus, ivabradine can
Libman-Sacks endocarditis, characterized by sterile verrucous vegetations, is a rare but typical cardiac manifestation of systemic lupus erythematosus. It primarily leads to lesions the mitral and aortic valves, isolated tricuspid valve involvement exceptional. We report case 40-year-old woman with large thickening, regurgitation. Clinical findings laboratory tests confirmed diagnosis The patient successfully recovered following replacement. Echocardiography definitive imaging modality for...
Abstract Background Accurate assessment of left ventricular (LV) systolic function is important after coronary artery bypass grafting (CABG). LV ejection fraction (LVEF) conventionally used to evaluate function; deformation parameters can be detect subtle dysfunction. It unclear whether an incised pericardium without sutures during CABG could affect morphology and function. We investigated the effect pericardial incision on CABG. Methods Intraoperative transesophageal echocardiography was...
This study aimed to investigate the effects of Case-based collaborative learning (CBCL) curriculum in webinar format on internal medicine residents’ knowledge covering cardiologic topics and their attitudes toward CBCL teaching module. is a novel small-group approach, that incorporates elements problem-based case-based learning, it has shown improve medical students’ mastery. However, few studies have explored its applicability for residents, especially format. prospective cohort included...
Abstract Background Nonobstructive coronary artery disease (NOCAD), characterized by the presence of myocardial ischemic symptoms and signs without obstructive coronaries, is a common clinical condition, but it less well understood. Few studies have analyzed gender differences in inducible ischemia assessed cardiopulmonary exercise test (CPET) NOCAD. Methods We conducted study 289 NOCAD patients (mean age 60, 56% women) with confirmed ⫹50% coronaries stenoses angiography who underwent...
Malignant pleural mesothelioma (MPM) is a highly invasive tumor caused primarily by asbestos exposure. In recent decades, the incidence of MPM has shown an increasing trend, posing great threat to human health. Although there currently no effective way treat MPM, patients can survive for more than 5 years if removed early. Several systematic reviews (SRs) have evaluated diagnostic value biomarkers diagnosing MPM. However, studies been conducted analyze quality these SRs and it remains...
Cardiopulmonary exercise test (CPET) provides the means to evaluate cardiopulmonary function and guide cardiac rehabilitation. The performance of acute myocardial infarction (AMI) patients at different times is on CPET.This was a cross-sectional study. Patients diagnosed as AMI in stable status were included performed low- level CPET (RAMP 10W). variables compared among four groups.Sixty one with conducted low-level from 3 15 days after AMI. stratified according quartiles CPET's time: 5 3-6...
Abstract LMNA mutations cause a variety of inherited diseases referred to as laminopathies which are associated with wide spectrum disease phenotypes, ranging from skeletal muscle disease, pre-mature ageing, metabolic disorders, and cardiac abnormalities. We present case 14-year-old boy dilated cardiomyopathy induced by the mutation (p. R429C) described its electrocardiogram imaging features.
Abstract Background: Accurate assessment of left ventricular (LV) systolic function is important after coronary artery bypass grafting (CABG). LV ejection fraction (LVEF) conventionally used to evaluate function; deformation parameters can be detect subtle dysfunction. It unclear whether an incised pericardium without sutures during CABG could affect morphology and function. We investigated the effect pericardial incision on CABG. Methods: Intraoperative transesophageal echocardiography was...
<title>Abstract</title> Background Heart failure with reduced ejection fraction (HFrEF) is an important cause of morbidity and mortality. This study aimed to evaluate the knowledge practices physicians in Beijing toward use guideline-directed medical therapy (GDMT) for HFrEF. Methods cross-sectional enrolled at 13 districts between November 2022 December 2022. A self-administered questionnaire was designed that included demographic, practice dimensions. Results The 290 (females, 63.79%)....
Objective To assess the changes of left ventricule and analyze influential factors in pulmonary hypertension (PH) by comparing ventricular volume function using single cardiac cycle real-time three dimensional echocardiography ( sRT-3DE ) two-dimensional (2DE).Methods In case group,there were 30 inpatients diagnosed as PH,systolic artery pressure(PASP)≥40 mmHg estimated echocardiography,excluding heart disease or congenital systemic-pulmonary circulation shunt.There healthy people control...
Abstract Background: Accurate assessment of left ventricular (LV) systolic function is important after coronary artery bypass grafting (CABG). LV ejection fraction (LVEF) conventionally used to evaluate function; deformation parameters can be detect subtle dysfunction. It unclear whether an incised pericardium without sutures during CABG could affect morphology and function. We investigated the effect pericardial incision on CABG. Methods: Intraoperative transesophageal echocardiography was...
Abstract Background: Already known ivabradine’s effects in decreasing atrial spontaneous activity and pulmonary veins, the focal tachycardia, New information is that it candidate for re-entrant arrhythmias.Case presentation :An 85-year-old woman with a history of underlying ischemic cardiomyopathy complained worsening heart failure symptoms due to rapid which was resistant several rate control drugs but responded well ivabradine. An electrophysiology study demonstrated roof dependent...