A5093371756- Acne and Rosacea Treatments and Effects
- Hidradenitis Suppurativa and Treatments
- Antimicrobial Resistance in Staphylococcus
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- T-cell and B-cell Immunology
- Trace Elements in Health
- Gut microbiota and health
- Oral Health Pathology and Treatment
- Immune responses and vaccinations
University of California, San Diego
2023-2024
Abstract Pathobionts have evolved many strategies to coexist with the host, but how immune evasion mechanisms contribute difficulty of developing vaccines against pathobionts is unclear. Meanwhile, Staphylococcus aureus (SA) has resisted human vaccine development date. Here we show that prior SA exposure induces non-protective CD4 + T cell imprints, leading blunting protective IsdB responses. Mechanistically, these SA-experienced cells express IL-10, which further amplified by vaccination...
Abstract Acne vulgaris, rosacea, and hidradenitis suppurativa are enduring inflammatory skin conditions that frequently manifest with akin clinical attributes, posing a considerable challenge for their distinctive diagnosis. While these do exhibit certain resemblances, they also demonstrate distinct underlying pathophysiological mechanisms treatment modalities. Delving into both the molecular parallels disparities among three disorders can yield invaluable insights refined diagnostics,...
ABSTRACT Acne vulgaris, rosacea, and hidradenitis suppurativa are enduring inflammatory skin conditions that frequently manifest with akin clinical attributes, posing a considerable challenge for their distinctive diagnosis. While these do exhibit certain resemblances, they also demonstrate distinct underlying pathophysiological mechanisms treatment modalities. Delving into both the molecular parallels disparities among three disorders can yield invaluable insights refined diagnostics,...