A5075132017- Fibromyalgia and Chronic Fatigue Syndrome Research
- Nerve injury and regeneration
- Signaling Pathways in Disease
- Retinal Development and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Retinal Diseases and Treatments
- Spinal Cord Injury Research
- Retinal Imaging and Analysis
- Acupuncture Treatment Research Studies
- Pain Mechanisms and Treatments
- Calpain Protease Function and Regulation
- Mental Health and Psychiatry
- Healthcare Decision-Making and Restraints
- Muscle metabolism and nutrition
- Phagocytosis and Immune Regulation
- Shoulder Injury and Treatment
- Cardiovascular Effects of Exercise
- interferon and immune responses
- Advanced Fluorescence Microscopy Techniques
- Musculoskeletal pain and rehabilitation
- Galectins and Cancer Biology
- Exercise and Physiological Responses
- Psychiatric care and mental health services
- 14-3-3 protein interactions
- Retinal and Macular Surgery
University of California, San Diego
2012-2023
University of the Pacific
2007-2010
Solve ME/CFS Initiative
2007
Age-related macular degeneration (AMD) is a leading cause of vision loss affecting tens millions elderly worldwide. Early AMD characterized by the appearance soft drusen, as well pigmentary changes in retinal pigment epithelium (RPE). These soft, confluent drusen can progress into two forms advanced AMD: geographic atrophy (GA, or dry AMD) choroidal neovascularization (CNV, wet AMD). Both result similar clinical progression terms central vision. The exact mechanism for developing early AMD,...
Postexertional malaise (PEM) is a defining characteristic of chronic fatigue syndrome (CFS) that remains source some controversy. The purpose this study was to explore the effects an exercise challenge on CFS symptoms from patient perspective.This included 25 female patients and 23 age-matched sedentary controls. All participants underwent maximal cardiopulmonary test. Subjects completed health well-being survey (SF-36) 7 days postexercise. also provided, approximately after testing, written...
Summary In the injured adult mammalian central nervous system (CNS), products are generated that inhibit neuronal sprouting and regeneration. recent years, most attention has focused on myelin-associated inhibitory proteins (MAIs) Nogo-A, OMgp, glycoprotein (MAG). Binding of MAIs to cell-surface receptors leads activation RhoA, growth cone collapse, neurite outgrowth inhibition. present study, we identify low-density lipoprotein (LDL) receptor-related protein-1 (LRP1) as a high-affinity,...
Protein kinase A (PKA) plays critical roles in neuronal function that are mediated by different regulatory (R) subunits. Deficiency either the RIβ or RIIβ subunit results distinct phenotypes. Although contributes to synaptic plasticity, it is least studied isoform. Using isoform-specific antibodies, we generated high-resolution large-scale immunohistochemical mosaic images of mouse brain provided global views several regions, including hippocampus and cerebellum. The isoforms concentrate...
In the central nervous system (CNS), fast neuronal signals are facilitated by oligodendrocyte-produced myelin sheath. Oligodendrocyte turnover or injury generates debris that is usually promptly cleared phagocytic cells. Failure to remove dying oligodendrocytes leads accumulation of degraded myelin, which, if recognized immune system, may contribute development autoimmunity in diseases such as multiple sclerosis. We recently identified low density lipoprotein receptor-related protein-1...
Neurotrophic factor and cAMP-dependent signaling promote the survival neurite outgrowth of retinal ganglion cells (RGCs) after injury. However, mechanisms conferring neuroprotection neuroregeneration downstream to these signals are unclear. We now reveal that scaffold protein muscle A-kinase anchoring protein-α (mAKAPα) is required for axon growth cultured primary RGCs. Although genetic deletion mAKAPα early in prenatal RGC development did not affect into adulthood, nor promoted death RGCs...
Age-related macular degeneration (AMD) is a leading cause of vision loss affecting tens millions elderly worldwide. Early AMD includes soft drusen and pigmentary changes in the retinal pigment epithelium (RPE). As people age, such confluent can progress into two forms advanced AMD, geographic atrophy (GA, or dry AMD) choroidal neovascularization (CNV, wet result central vision. The exact mechanism for developing early progressing to stage disease still largely unknown. However, significant...
A comprehensive view of CFS patients during conditions post-exertional malaise can provide an integrated perspective on the pathophysiology illness. PURPOSE: To compare metabolic responses and neurocognitive consequences a maximal exercise challenge between control subjects. METHODS: Twenty (n=20) women with twenty sedentary subjects performed graded test to exertion. Cardiopulmonary analysis was test. Blood samples for plasma lactate glucose were collected before after Nasal acoustic...
Symptom exacerbation following physical stress has been documented in illnesses such as multiple sclerosis (MS), lupus and rheumatoid arthritis (RA). Similar phenomenology reported CFS but is not well understood. PURPOSE: The purpose of this study was to explore symptom an exercise challenge patients relative a sedentary control population. METHODS: Forty female subjects (n=40), 20 matched controls served subjects. All participants underwent graded maximal cardiopulmonary test (CPX). Two...