A5063926108- HIV Research and Treatment
- Immune Cell Function and Interaction
- vaccines and immunoinformatics approaches
- Nutrition, Genetics, and Disease
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Immunodeficiency and Autoimmune Disorders
- BRCA gene mutations in cancer
- Ion Channels and Receptors
- Adenosine and Purinergic Signaling
- DNA Repair Mechanisms
- SARS-CoV-2 and COVID-19 Research
- HIV-related health complications and treatments
- Wireless Body Area Networks
- Microbial Inactivation Methods
- Respiratory and Cough-Related Research
- Cancer-related Molecular Pathways
- Microfluidic and Bio-sensing Technologies
- Vagus Nerve Stimulation Research
- Hepatitis C virus research
Hospital Universitari Germans Trias i Pujol
2017-2023
IrsiCaixa
2017-2023
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2020
Universitat Autònoma de Barcelona
2017
Harvard University
1997-2000
Massachusetts General Hospital
1996-1997
Germ-line mutations in the BRCA1 and BRCA2 genes predispose women to breast cancer. are found approximately 12 percent of with cancer early onset, specific mutation causing a deletion adenine guanine (185delAG), which is present 1 Ashkenazi Jewish population, contributes 21 cancers among young women. The contribution onset unknown.
Five to ten percent of individuals with melanoma have another affected family member, suggesting familial predisposition. Germ-line mutations in the cyclin-dependent kinase (CDK) inhibitor p16 been reported a subset pedigrees, but their prevalence is unknown more common cases that do not involve large families multiple members. We screened for germ-line and two other candidate genes, p19ARF CDK4, 33 consecutive patients treated melanoma; these had at least one first or second degree relative...
The post-COVID-19 condition (PCC) is a disabling syndrome affecting at least 5%-10% of subjects who survive COVID-19. SARS-CoV-2 mediated vagus nerve dysfunction could explain some PCC symptoms, such as dysphonia, dysphagia, dyspnea, dizziness, tachycardia, orthostatic hypotension, gastrointestinal disturbances, or neurocognitive complaints.
ABSTRACT Intact and broad immune cell effector functions specific individual cytokines have been linked to HIV disease outcome, but their relative contribution control remains unclear. We asked whether the proteome of secreted signaling factors in peripheral blood can be used discover pathways critical for host viral control. A custom glass-based microarray, able measure >600 plasma proteins involved cell-to-cell communication, was protein profiles 96 HIV-infected, treatment-naive...
Background Fine definition of targeted CD8+ T-cell epitopes and their human leucocyte antigen (HLA) class I restriction informs iterative improvements HIV-1 vaccine designs may predict early success or failure. Here, lymphocytes from volunteers, who had received candidate HIVconsv vaccines expressing conserved sub-protein regions HIV-1, were used to define the optimum-length target HLA restriction. In HIV-1-positive patients, responses predominantly recognize immunodominant, but...
Neurocognitive disorders are frequently reported in people living with HIV (PLWH) even the introduction of combined antiretroviral treatment (cART). To identify biomarkers and potential therapeutic tools to target infection peripheral blood central nervous system (CNS), plasma proteomics were applied untreated chronic HIV-infected individuals different levels virus control.
The development of a vaccine able to prevent infection or severe disease course SARS-CoV-2 is priority stem the current COVID-19 pandemic and be better prepared for future flare-ups.To accelerate T-cell immunogen design, many approaches are employing epitope prediction strategies.Although such have great merit, it also important that unbiased characterizing response incorporated into in order generate comprehensive picture total virus-specific define correlates protective immunity against...
CD4+ T-cell responses play an important role in the immune control of human immunodeficiency virus type 1 (HIV-1) infection and as such should be efficiently induced by vaccination. It follows that definition HIV-1-derived peptides recognized T cells association with HLA class II molecules will guide vaccine development. Here, we have characterized fine specificity elicited recipients a candidate delivering conserved regions HIV-1 proteins designated HIVconsv. The majority these 19 most...
Sub-Saharan Africa carries the biggest burden of human immunodeficiency virus type 1 (HIV-1)/AIDS epidemic and is in an urgent need effective vaccine. CD8+ T cells are important component host immune response to HIV-1 may be harnessed if a vaccine effective. recognize leukocyte antigen (HLA)-associated viral epitopes HLA alleles vary significantly among different ethnic groups. It follows that definition HIV-1-derived peptides recognized by geographically relevant regions will critically...