A5088848031- Adipose Tissue and Metabolism
- Lipid metabolism and biosynthesis
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Peroxisome Proliferator-Activated Receptors
- Regulation of Appetite and Obesity
- Fatty Acid Research and Health
- Cardiovascular Disease and Adiposity
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Apelin-related biomedical research
- Muscle metabolism and nutrition
- Adipokines, Inflammation, and Metabolic Diseases
- Gout, Hyperuricemia, Uric Acid
- Stress Responses and Cortisol
- Alcohol Consumption and Health Effects
- Hormonal Regulation and Hypertension
- Endoplasmic Reticulum Stress and Disease
- Neuropeptides and Animal Physiology
- Olfactory and Sensory Function Studies
- Blood Pressure and Hypertension Studies
- Inflammatory mediators and NSAID effects
- Lipid metabolism and disorders
- Cholesterol and Lipid Metabolism
Federal University of São João del-Rei
2014-2024
Universidade de São Paulo
2006-2012
Universidade Federal de Mato Grosso
2010-2012
Délégation Paris 5
2006-2007
Université Paris Cité
2006-2007
Inserm
2006-2007
Clinics Hospital of Ribeirão Preto
2006-2007
We had previously shown that adipose tissue increased in rats fed a low-protein, high-carbohydrate (LPHC) diet (6% protein, 74% carbohydrate) without simultaneous increase the de novo fatty acids (FA) synthesis. In addition, impairment insulin signaling tissues was observed these rats. For this study, we hypothesized pathway is preserved livers from rats, which contributes to an liver lipogenesis and, consequently, weight of tissue. also glycerol triacylglycerol important substrate for FA...
A low-protein, high-carbohydrate (LPHC) diet for 15 days increased the lipid content in carcass and adipose tissues of rats. The aim this work was to investigate mechanisms increase retroperitoneal white tissue (RWAT) these animals. LPHC induced an approximately two- tenfold serum corticosterone TNF-α, respectively. rate de novo fatty acid (FA) synthesis vivo reduced (50%) rats, lipoprotein lipase activity (100%). In addition, glycerokinase (60%), phosphoenolpyruvate carboxykinase decreased...
The physiological role of epinephrine in the regulation skeletal muscle protein metabolism under fasting is unknown. We examined effects plasma depletion, induced by adrenodemedullation (ADMX), on fed and 2-day-fasted rats. In rats, ADMX for 10 days reduced mass, cross-sectional area extensor digitorum longus (EDL) fibers, phosphorylation levels Akt. addition, led to a compensatory increase sympathetic activity, as estimated rate norepinephrine turnover; this was accompanied high rates...
The amount of triacylglycerol (TAG) that accumulates in adipose tissue depends on 2 opposing processes: lipogenesis and lipolysis. We have previously shown the weight lipid content epididymal (EPI) increases growing rats fed a low-protein, high-carbohydrate (LPHC) diet for 15 days. aim this work was to study pathways involved lipolysis, which ultimately regulate accumulation tissue. De novo fatty acid synthesis evaluated vivo similar an LPHC or control diet; however, LPHC-fed had decreased...
In vivo fatty acid synthesis and the pathways of glycerol-3-phosphate (G3P) production were investigated in brown adipose tissue (BAT) from rats fed a cafeteria diet for 3 weeks. spite BAT activation, promoted an increase carcass content. Plasma insulin levels markedly increased diet-fed rats. Two insulin-sensitive processes, glucose uptake (which was used to evaluate G3P generation via glycolysis) diet. Direct glycerol phosphorylation, evaluated by glycerokinase (GyK) activity incorporation...
Interferon gamma (IFN-gamma) was previously shown to promote fatty acid (FA) release from adipose tissue (AT). Net lipolysis is an equilibrium between triglyceride breakdown and FA re-esterification. The latter requires activated glyceroneogenesis for glycerol-3-phosphate synthesis increased cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C), the key enzyme in this pathway. We wondered whether PEPCK-C would be IFN-gamma targets. injected mice with IFN-gamma, exposed either AT explants...
We have previously shown that a high-protein, carbohydrate-free diet can decrease the production of glycerol-3-phosphate (G3P) from glucose and increase glyceroneogenesis in both brown (BAT) epididymal (EAT) adipose tissue. Here, we utilized an in-vivo approach to examine hypothesis there is reciprocal regulation G3P synthesis (via glycolysis) BAT, EAT liver fasted rats cafeteria diet-fed rats. Glyceroneogenesis played prominent role generation (~70 %) as well BAT (~80 controls The induced...
The pathways of glycerol-3-phosphate (G3P) generation for glyceride synthesis were examined in precision-cut liver slices fasted and diabetic rats. incorporation 5 mM [U-(14)C]glucose into glyceride-glycerol, used to evaluate G3P via glycolysis, was reduced by approximately 26-36% glycolytic flux 60% both groups. 1.0 [2-(14)C]pyruvate glyceride-glycerol (glyceroneogenesis) increased 50% 36% rats, respectively, which also showed a two-fold increase the activity phosphoenolpyruvate...