A5019742601- Adipose Tissue and Metabolism
- Cancer, Lipids, and Metabolism
- Muscle metabolism and nutrition
- Lipid metabolism and biosynthesis
- Adipokines, Inflammation, and Metabolic Diseases
- Fatty Acid Research and Health
- Polysaccharides Composition and Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Peroxisome Proliferator-Activated Receptors
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Lipid metabolism and disorders
- Liver Disease Diagnosis and Treatment
- Cholesterol and Lipid Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Dietary Effects on Health
- Microbial Metabolites in Food Biotechnology
- Health, Education, and Aging
- Dental materials and restorations
- Educational Practices and Policies
- Nutritional Studies and Diet
- Healthcare Regulation
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Exercise and Physiological Responses
- Eosinophilic Disorders and Syndromes
Universidade Estadual de Campinas (UNICAMP)
2014-2025
University of California, Berkeley
2015
University of Oulu
2013
University of Helsinki
2013
Oulu University Hospital
2013
Universidade Federal do Rio de Janeiro
2013
Abstract Fatty acid synthase (FASN) is the enzyme responsible for endogenous synthesis of saturated fatty palmitate. In contrast to most normal cells, malignant cells depend on FASN activity growth and survival. fact, overexpressed in a variety human cancers including cutaneous melanoma, which its levels expression are associated with poor prognosis depth invasion. Here, we show that specific inhibition by antiobesity drug Orlistat or siRNA able significantly reduce proliferation promote...
Fatty acid synthase (FASN) is the biosynthetic enzyme responsible for endogenous synthesis of fatty acids. It downregulated in most normal cells, except lipogenic tissues such as liver, lactating breast, fetal lung, and adipose tissue. Conversely, several human cancers, including head neck squamous cell carcinomas (HNSCC), overexpress FASN, which has been associated with poor prognosis recently suggested a metabolic oncoprotein. Orlistat an irreversible inhibitor FASN activity cytotoxic...
Different regimens of food restriction have been associated with protection against obesity, diabetes and CVD. In the present study, we hypothesised that would bring benefits to atherosclerosis- diabetes-prone hypercholesterolaemic LDL-receptor knockout mice. For this purpose, 2-month-old mice were submitted an intermittent fasting (IF) regimen (fasting every other day) over a 3-month period, which resulted in overall 20 % reduction intake. Contrary our expectation, epididymal carcass fat...
Susceptibility to obesity differs depending on the genetic background and housing temperatures. We have recently reported that CETP expressing female mice are leaner due increased lipolysis, brown adipose tissue (BAT) activity, body energy expenditure compared nontransgenic (NTg) littermates under standard temperature (22°C). The aim of this study is evaluate how expression affects temperature, composition, metabolism during cold exposure (4°C) thermoneutrality (30°C). When submitted cold,...
Nonalcoholic fatty liver disease (NAFLD) is the principal manifestation of in obesity and metabolic syndrome. By comparing hypertriglyceridemic transgenic mice expressing apolipoprotein (apo) CIII with control nontransgenic (NTg) littermates, we demonstrated that overexpression apoCIII, independent a high‐fat diet (HFD), produces NAFLD‐like features, including increased lipid content; decreased antioxidant power; expression TNF α , receptor, cleaved caspase‐1, interleukin‐1 β ; adiponectin...
The consumption of vegetables has been correlated with reduced risk chronic non-communicable diseases due to the high fiber content and bioactive compounds found in vegetables. arrowleaf elephant ear (Xanthosoma sagittifolium), which is known Brazil as taioba, a common plant tropical America. Although its leafy portion possesses nutritional value, it not widely consumed well studied. This study assessed effect lyophilised taioba leaf (LTL) hypolipidemic prebiotic agent. Thirty-two Wistar...
Hypertriglyceridemia is a common type of dyslipidemia found in obesity. However, it not established whether primary hyperlipidemia can predispose to Evidences have suggested that proteins primarily related plasma lipoprotein transport, such as apolipoprotein (apo) CIII and E, may significantly affect the process body fat accumulation. We previously observed an increased adiposity response high diet (HFD) mice overexpressing apoCIII. Here, we examined potential mechanisms involved this...
Abstract Several studies have shown that fruits and vegetables contribute to protect against degenerative pathologies such as cardiovascular diseases, diabetes, cancer, mainly due the presence of dietary fiber (DF) polyphenols. Taioba ( Xanthosoma sagittifolium ) is an edible aroid widely grown in many parts Africa, America, Asia. The tubers portions taioba are consumed; however, leafy generally discarded, despite their high nutritive value. In this study, we partly characterized DF...
Introdução: O tecido adiposo e suas células tem sido amplamente estudados devido à sua relação íntima com a obesidade. Objetivo: Identificar aspectos históricos relevantes sobre o avanço na compreensão da função metabólica do adiposo, sobretudo quanto ao seu potencial como alvo terapêutico no controle de doenças metabólicas. Materiais Métodos: Foi feita uma revisão narrativa literatura, sem restrição data, priorizando fontes primárias indexadas pela base dados PubMed. Resultados: As...
Abstract Mirabegron is a selective β₃‐adrenergic receptors agonist, which has been recently shown to improve metabolic health in rodents and humans. In this study, we investigated the effects of 2‐week mirabegron treatment on parameters mice with diet‐induced obesity (DIO). C57BL/6JUnib were divided into control (CTR) obese (OB) groups treated vehicle, an OB group (OB + MIRA). The fed high‐fat diet for 12 weeks. (10 mg/kg/day) was administrated orally by gavage from weeks 10–12. After 2...
A aterosclerose, principal responsável pela patogênese do infarto miocárdico e cerebral, bem como gangrena por outras doenças vasculares periféricas, permanece causa de morbidade mortalidade nas populações "ocidentalizadas". Estima-se que 17,5 milhões pessoas morreram cardiovasculares em 2005, o representou 30% das causas morte nesse ano, que, 2015, 20 morrerão no mundo. Os ácidos graxos n-3, principalmente os cadeia longa, encontrados nos peixes, têm-se mostrado particularmente úteis na...
Cholesteryl ester transfer protein (CETP) is a plasma that mediates the exchange of triglycerides for esterified cholesterol between HDL and apoB-lipoproteins. Previous studies suggest CETP may modify glucose metabolism in patients or cultured cells. In this study, we tested if stable expression would impair metabolism. We used human transgenic mice non-transgenic littermate controls (NTg), fed with control high fat diet, as well dyslipidemic background aging conditions. Assays included...
Abstract Our previous studies show that cafeteria diet increases body adiposity, plasma insulin levels, and sympathetic activity to brown adipose tissue (BAT) white (WAT) of Wistar rats, leading rapid progressive changes in the metabolic profile. The identification suitable reference genes are not affected by experimental conditions is a critical step accurate normalization reverse transcription quantitative real‐time PCR (qRT‐PCR), commonly used assay elucidate gene expression In present...
Nutritional recovery with a soyabean diet decreases body and fat weights when compared casein diet. We investigated whether the reduced adiposity observed in rats recovering from early-life malnutrition results alterations lipid metabolism white adipose tissue (WAT) and/or brown (BAT). Male mothers fed either 17 or 6 % protein during pregnancy lactation were maintained on (CC LC groups), (CS LS groups) (LL group) diets over 60 d. The had similar relative food intakes, but lower...
ABSTRACT Susceptibility to obesity differs depending on the genetic background and housing temperatures. We have recently reported that CETP expressing female mice are leaner due increased lipolysis, brown adipose tissue (BAT) activity body energy expenditure compared non-transgenic (NTg) littermates under standard temperature (22°C). The aim of this study is evaluate how expression affect temperature, composition metabolism during cold exposure (4°C) thermoneutrality (30°C). When submitted...