A5077844884- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Mechanical Circulatory Support Devices
- Congenital Heart Disease Studies
- Prenatal Substance Exposure Effects
- Neonatal Health and Biochemistry
- Cardiac Structural Anomalies and Repair
- Congenital Diaphragmatic Hernia Studies
- Respiratory Support and Mechanisms
- Maternal Mental Health During Pregnancy and Postpartum
- Anesthesia and Neurotoxicity Research
- Pulmonary Hypertension Research and Treatments
- Vascular anomalies and interventions
- Disaster Response and Management
- COVID-19 Clinical Research Studies
- Simulation-Based Education in Healthcare
- Retinopathy of Prematurity Studies
- Trigeminal Neuralgia and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Congenital Anomalies and Fetal Surgery
- Vascular Malformations and Hemangiomas
- Vascular Anomalies and Treatments
- Vascular Tumors and Angiosarcomas
- Vascular Malformations Diagnosis and Treatment
- Family and Patient Care in Intensive Care Units
St. Christopher's Hospital for Children
2021-2025
Drexel University
2021-2025
John H. Stroger, Jr. Hospital of Cook County
2013-2023
Phoenix Children's Hospital
2023
Case Western Reserve University
2023
Ross University School of Medicine
2023
American University of Barbados
2023
Northwestern Medicine
2023
New Jersey Institute of Technology
2023
Saint Louis University
2023
Veno-venous (VV) extracorporeal membrane oxygenation (ECMO) is associated with fewer neurological complications and decreased mortality compared to veno-arterial (VA) ECMO in neonatal respiratory failure. The Crescent right atrial (RA) cannula the only dual-lumen for VV designed have tip atrium. purpose of this study describe experience early use RA cannula. We performed a retrospective cohort 58 neonates infants cannulated from September 2021 through August 2023 at 15 institutions...
Treatment of neonates with persistent pulmonary hypertension newborn includes optimization ventilatory support, use vasodilators, and/or inotropic support. If refractory to this management, some may require extracorporeal membrane oxygenation. We describe a case series 10 treated vasopressin in single tertiary center. Mean initiation time was at 30 h life dose ranging from 85 milliunits/kg/h. Oxygenation index decreased after 12 exposure (25 11) and mean arterial pressure improved 1 (45 58...
Background: Despite innovative advances in neonatal medicine, intraventricular hemorrhage (IVH) continues to be a significant complication intensive care units globally. Objective: The study aimed discern the variables heightening risk of severe IVH (Grade III and IV) extremely premature infants weighing less than 750 grams. We postulated that descending hematocrit (Hct) trend during first week life could serve as predictive marker for development this vulnerable population. Methods: This...
Recent data describe an increasing use of extracorporeal membrane oxygenation (ECMO) in neonates with various clinical conditions besides primary respiratory or cardiac diagnoses. Infants underlying genetic disorders characterized by cardiopulmonary failure pose unique management challenges. When pathognomonic dysmorphic features for common diagnoses are not present, the prognosis is uncertain at best when determining ECMO candidacy. Lengthy turnaround times testing often delay definitive...
Spleen rupture in an extremely premature newborn is very rare event. High index of suspicion required to make timely diagnosis and thereafter appropriate management. We present a case premature, low birthweight who presented with severe anemia secondary splenic rupture. It was managed conservatively without splenectomy resulting complete resolution symptoms. Although non-operative management pediatric injuries now recognized as the treatment choice, there little experience newborns.
Objective: To determine the effectiveness of lacosamide (LCS) in refractory trigeminal neuralgia (TN) patients. Background There are several medications used for medical treatment TN; however, they often ineffective due to lack efficacy or intolerable adverse effects. LCS has a novel mechanism by selectively enhancing slow inactivation voltage dependent sodium channels. Design/Methods: We performed retrospective chart review eleven subjects who had been diagnosed with TN and received as...
The study aims to describe our experience with the implementation of phenobarbital as a primary sedation strategy during neonatal extracorporeal membrane oxygenation (ECMO).
Objective This study aimed to compare magnetic resonance imaging (MRI) severity scores and in-hospital outcomes among neonates with perinatal hypoxic–ischemic encephalopathy (HIE) without exposure sedation–analgesia (SA) during therapeutic hypothermia (TH). Study Design A single-center, retrospective cohort of HIE undergoing TH between January 2010 December 2020. Demographics, clinical characteristics, MRI scores, were compared patients SA those use. Results Of the 131 neonates, 55 (42%) did...
Introduction: Although associated with respiratory morbidity, elective endotracheal intubation (ETI) for laser photocoagulation retinopathy of prematurity (ROP) is the standard practice at our institution, 100% patients undergoing preoperation ETI. To mitigate this risk, we strove to reduce percentage infants intubated by 30% June 2022. Methods: We assembled a multidisciplinary team and implemented deep sedation guideline utilizing dexmedetomidine, fentanyl, midazolam noninvasive ventilation...
Pulmonary hemorrhage (PH) is an infrequent and potentially fatal event in term neonates. Reports of successful management PH on extracorporeal membrane oxygenation (ECMO) are limited, given the accentuated risk mortality imposed by use heparin to prevent thrombosis ECMO. We present a case neonate with hypoxic ischemic encephalopathy undergoing controlled hypothermia who developed respiratory failure, hemodynamic instability, Enterobacter cloacae pneumonia sepsis complicated severe required...
Safety and efficacy data on controlled hypothermia (CH) for neonates with moderate to severe hypoxic ischemic encephalopathy has been extrapolated a subgroup of these patients who also require extracorporeal membrane oxygenation refractory persistent pulmonary hypertension the newborn (PPHN). However, safety concomitant use CH (ECMO) are lacking.
Joshi, S. MD; Young, W. L. Chin, Vang, M. Feng, PhD; Pile-Spellman, J. Vulliemoz, Author Information
Background: The landscape of ECMO for respiratory failure has changed over the past years, primarily because unavailable equipment. OriGen catheters were recalled in 2019 compelling centers to opt veno-arterial (VA) given technical complexity and reported complications Avalon bicaval catheter placement. We describe our experience with percutaneous veno-venous (VV) cannulation short-term neonatal outcomes institution. Methods: Retrospective cohort review VV patients from 2023 a level IV...
Introduction: Initiation of pediatric extracorporeal membrane oxygenation (ECMO) is often complicated by systemic inflammatory response syndrome (SIRS). Blood products utilized in circuit prime may augment the induced ECMO initiation. We hypothesize that donor blood contain proteins which are activated on exposure to circuit. Materials and Methods: Single-center prospective study an ex-vivo model utilizing reconstituted or whole blood. Samples were collected stored at regular intervals...
A newborn presents with a raised plaque on the left side of face involving scalp, forehead, and eye. ### Prenatal Birth Histories ### Presentation Immediately after birth, this 715-g female infant was noted to have red macule region around Physical Examination The facial became more prominent during first month birth. By 2 months age, …
Background: A variety of illicit drugs abused by women during pregnancy cross the placenta. All these may be associated with short-term deleterious effects on birth outcomes that are often drug specific. For instance, maternal cocaine use result in catastrophic like placental abruption, opiate neonatal abstinence syndrome and marijuana preterm birth. Prevalence specific has probably shifted over years keeping popularity or access to substances …
Background: Delayed cord clamping (DCC) and umbilical milking (UCM) are two recently advocated interventions to enhance placental transfusion at birth. DCC MCM might increase blood volume help neonates transition from fetal neonatal circulation. Objective: To evaluate the effects of delayed (DCC), (UCM), immediate (ICC) on very low birth weight (VLBW) neonates. Methods: At our institution, ICC was routinely done until December, 2012 when it replaced by DCC. UCM implemented in March, 2015....
Background: A variety of illicit drugs abused by women during pregnancy cross the placenta. All these may be associated with short-term deleterious effects on birth outcomes that are often drug specific. For instance, maternal cocaine use result in catastrophic like placental abruption, opiate neonatal abstinence syndrome and marijuana preterm birth. Prevalence specific has probably shifted over years keeping popularity or access to substances …
Background: Recent emergence of COVID-19, a disease caused by the novel coronavirus SARS-CoV-2, has posed unprecedented challenges to various aspects healthcare system The complexity and acuity NICU patients, along with extreme precautions needed safeguard families workers (HCWs) from COVID-19 motivated creative thinking multidisciplinary collaboration We present use simulation design, test implement safety guidelines for preparedness in Objective: hypothesize that simulation-based...
Background: Persistent pulmonary hypertension of newborn (PPHN) affects 1.9 per 1000 live births and has a varied mortality ranging between 4-33%. Although inhaled nitric oxide (iNO) reduced the need for Extracorporeal membrane oxygenation (ECMO) in this population, refractory cases persist. Vasopressin is gaining favor as treatment modality neonates despite limited data concerns hyponatremia decreased intestinal perfusion. Objective: To describe effect vasopressin on systemic blood …
Background The COVID-19 pandemic represents an unprecedented global crisis that has health care workers (HCW) facing unique challenges. estimated infection risk of HCW treating patients been demonstrated to be significant. In order assure patient and provider safety with effective management, optimal preparedness is key. aim this project was assess optimize unit readiness for high procedures in appropriate use personal protective equipment (PPE). Methods Two …