A5038925472- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Congenital Heart Disease Studies
- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Cardiovascular Conditions and Treatments
- Neonatal and fetal brain pathology
- Infant Development and Preterm Care
- Respiratory Support and Mechanisms
- Infant Nutrition and Health
- Child Nutrition and Feeding Issues
- Intestinal Malrotation and Obstruction Disorders
- Clinical Nutrition and Gastroenterology
- Electrolyte and hormonal disorders
- Esophageal and GI Pathology
- Neuroscience of respiration and sleep
- Urinary Tract Infections Management
- Pediatric Pain Management Techniques
- Health Sciences Research and Education
- Pediatric Urology and Nephrology Studies
- Social Media in Health Education
- Nutrition, Health and Food Behavior
- Musculoskeletal pain and rehabilitation
- Family and Patient Care in Intensive Care Units
- Blood disorders and treatments
University of Tennessee Health Science Center
2016-2025
Le Bonheur Children's Hospital
2015-2025
University of Tennessee at Knoxville
2025
Children's Hospital of Pittsburgh
2022
University of Pittsburgh
2022
Children's Hospital of Philadelphia
2022
University of Pennsylvania
2022
Regional Medical Center
2017-2020
British Columbia Children's Hospital
2019
Children's Hospital of Los Angeles
2017
The mistranslation-induced protein misfolding hypothesis predicts that selection should prefer high-fidelity codons at sites which translation errors are structurally disruptive and lead to aggregation. To test this hypothesis, we analyzed the relationship between codon usage bias structure in genomes of four model organisms, Escherichia coli, yeast, fly, mouse. Using both Mantel–Haenszel procedure, applies categorical data, a newly developed association for continuous variables, find...
Introduction Extracorporeal membrane oxygenation (ECMO) requires a multidisciplinary healthcare team. The Life Support Organization publishes training guidelines but leaves specific requirements up to each institution. Simulation has shown promise, it is unclear how many institutions have incorporated simulation techniques into ECMO date. Methods We sent an electronic survey coordinators at sites in the United States. Participants were asked about practices and use of for training....
A term, healthy infant presented with respiratory distress and severe pulmonary hypertension (PH). With an unclear aetiology the intent to decrease right ventricular afterload, vasodilators were initiated. Follow-up imaging revealed a supravalvular mitral ring as cause of PH which resolved after surgical resection membrane. Supravalvular is rare left-side congenital heart disease lesion that can lead usually between infancy toddler years, but be easily missed in setting concurrent large...
Veno-venous (VV) extracorporeal membrane oxygenation (ECMO) is associated with fewer neurological complications and decreased mortality compared to veno-arterial (VA) ECMO in neonatal respiratory failure. The Crescent right atrial (RA) cannula the only dual-lumen for VV designed have tip atrium. purpose of this study describe experience early use RA cannula. We performed a retrospective cohort 58 neonates infants cannulated from September 2021 through August 2023 at 15 institutions...
Abstract Objective This study reports on patent ductus arteriosus (PDA) therapy trends across the Children’s Hospital Neonatal Consortium. Study design We performed a 12-year (2011–2022) retrospective of premature infants (< 33 weeks) with PDA. utilized descriptive statistics to compare demographic, inpatient, and discharge characteristics in 3-year epochs. Result From 54,813 infants, 19,843 (36%) had diagnosis Use pharmacotherapy increased 44% (relative) over time, mostly acetaminophen...
Abstract: "What we know is little, and what are ignorant of immense"; the last words Laplace still apply to diagnosis management patent ductus arteriosus (PDA). Despite decades research, searching for right approach care patients with PDA. Nuances myocardial structural changes cardiopulmonary interactions prolonged exposure excess pulmonary blood flow have played an important role in decision-making. The availability medical treatments poor efficacy and, historically, surgical ligation as...
Our aim was to describe laboratory findings and imaging results for neonatal patients diagnosed with urinary tract infection (UTI).Medical records were reviewed infants UTI in a single intensive care unit (NICU) over 13-year period.Of the 8,241 admitted NICU during study period, 137 UTI. Imaging 101 patients. Renal pelvis dilation found 34% of vesicoureteral reflux 21%. not associated (OR: 0.53 [95% CI: 0.18-1.5]). The sensitivity urinalysis detect positive culture 76%, specificity 41%....
Congenital diaphragmatic hernia occurs when a portion of the fetal diaphragm is absent, allowing abdominal contents to enter thorax, and associated with impaired pulmonary development. Although overall mortality near 30%, rate less than 15% may be possible by following standardized multidisciplinary care plan. Fetal diagnosis evaluation can improve coordination care, but there no clear role for intervention. After birth, gentle ventilation permissive hypercapnia supports infant while...
Background: Pulmonary hypertension (PH) is a common comorbidity in infants with bronchopulmonary dysplasia (BPD). Sildenafil widely recognized therapy for PH, but its efficacy BPD questionable. We propose to assess the of sildenafil BPD-associated PH as evaluated based on transthoracic echocardiography (TTE) changes and clinical measures. Methods: Data were retrospectively prospectively collected. Inclusion criteria gestational age (GA) < 32 weeks, birth weight (BW) 1500 g severe BPD,...
Sham feeding may enhance development of oral skills in neonates after bowel surgery and decrease stress levels mothers. In this pilot study, we test the feasibility sham feeding, identify safety hazards, assess maternal satisfaction.A convenience sample 15 postoperative was enrolled. with unfortified human milk offered following a strict advancement protocol beginning 5 mL once daily increasing up to 30 mL, three times daily. Continuous gastric suction used during feeding. Each mother...
Intercenter variation exists in the management of hypoxic-ischemic encephalopathy (HIE). It is unclear whether increased resource utilization translates into improved neurodevelopmental outcomes.To determine if higher during first 4 days age, quantified by hospital costs, associated with survival without impairment (NDI) among infants HIE.Retrospective cohort analysis neonates HIE who underwent therapeutic hypothermia (TH) at US children's hospitals participating Children's Hospitals...
Objective The aim of this study was to describe the use, duration, and intercenter variation analgesia sedation in infants with congenital diaphragmatic hernia (CDH). Study Design This is a retrospective analysis analgesia, sedation, neuromuscular blockade use neonates CDH. Patient data from 2010 2016 were abstracted Children's Hospitals Neonatal Database linked Pediatric Health Information System. Patients excluded if they also had non-CDH conditions likely affect medications. Results A...