A5033717801- Colorectal and Anal Carcinomas
- Cervical Cancer and HPV Research
- Colorectal Cancer Surgical Treatments
- Retinal and Optic Conditions
- Traumatic Ocular and Foreign Body Injuries
- HIV Research and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Facial Trauma and Fracture Management
- Pancreatic function and diabetes
- HIV-related health complications and treatments
- Mosquito-borne diseases and control
- Global Cancer Incidence and Screening
- Mechanical Circulatory Support Devices
- Health Systems, Economic Evaluations, Quality of Life
- Healthcare cost, quality, practices
- Economic and Financial Impacts of Cancer
- Obstructive Sleep Apnea Research
- Autoimmune and Inflammatory Disorders
- Cancer-related Molecular Pathways
- Inflammatory Bowel Disease
- Cardiovascular Health and Disease Prevention
- Genital Health and Disease
- Enhanced Recovery After Surgery
- Clostridium difficile and Clostridium perfringens research
- Malaria Research and Control
Ferring Pharmaceuticals (United States)
2021
University Hospitals of Leicester NHS Trust
2021
Worcestershire Royal Hospital
2016-2020
Government of Gujarat
2020
Gilead Sciences (United States)
2019-2020
Ganpat University
2020
State University of New York
2019
SUNY Downstate Health Sciences University
2019
JSS Academy of Higher Education and Research
2016
Worcestershire Acute Hospitals NHS Trust
2016
Abstract Background Treatment with vesatolimod, an investigational, oral, toll-like receptor 7 (TLR7) agonist, leads to sustained viral remission in some non-human primates when combined anti-envelope antibodies or therapeutic vaccines. We report results of a Phase Ib study evaluating safety, pharmacokinetics, and pharmacodynamics vesatolimod adults living human immunodeficiency virus (HIV)–1. Methods In this double-blind, multicenter, placebo-controlled trial, participants on antiretroviral...
Abstract Background Colorectal cancer often presents with obstruction needing urgent, potentially life-saving decompression. The comparative efficacy and safety of endoluminal stenting versus emergency surgery as initial treatment for such patients is uncertain. Methods Patients left-sided colonic radiological features carcinoma were randomized to using a combined endoscopic/fluoroscopic technique followed by elective 1–4 weeks later, or surgical decompression without tumour resection....
AIM:To perform a systematic review and meta-analysis on post-operative complications after surgery for Crohn's disease (CD) comparing biological with no therapy. METHODS:PubMed, Medline Embase databases were searched to identify studies postoperative outcomes in CD patients receiving therapy those who did not.A random-effects model was used calculate pooled odds ratios (OR) confidence intervals (CI) each outcome measure of interest. RESULTS:A total 14 included metaanalysis, comprising 5425...
Abstract Background Immunosuppression is a known risk factor for anal human papillomavirus (HPV) disease, including squamous cell carcinoma. Additional factors HPV-related disease have not been studied in the renal transplant population. The demographics of HPV and associated were investigated this Methods Anal cytology polymerase chain reaction used to assess cohort recipients at Royal London Hospital. Risk with increased immunosuppression exposure collated determine any association...
Human papilloma virus (HPV) infection is considered as an important aetiological factor for anal squamous cell carcinoma (ASCC) but not sufficient tumour progression. This poorly understood at the molecular level. Using largest cohort of cases to date we investigated mechanisms underlying ASCC development, in particular roles TP53, MDM2 and AKT. Viral our occurred high frequency (73%, 94/128) with HPV16 accounting majority (86%, 81/94) infected cases. Only 4% (5/119) ASCCs showed TP53 (exons...
ABSTRACT Finafloxacin is a new fluoroquinolone antibiotic with the unique property of increasing antibacterial activity at pH values lower than neutral. Whereas its neutral matches that other quinolones in clinical use, it expected to surpass this tissues and body fluids acidified by infection or inflammation processes. Pharmacokinetic parameters oral single multiple doses up 800 mg finafloxacin safety/tolerability observations were assessed phase I study including 95 healthy volunteers....
Ankylosing spondylitis (AS) patients are most challenging. These patient present the serious array of intubation and difficult airway imaginable, secondary to decrease or no cervical spine mobility, fixed flexion deformity thoracolumbar possible temporomandibular joint disease. Sound clinical judgment is critical for timing selecting method intervention. The retrograde technique an important option when fiberoptic bronchoscope not available, other applicable gaining access surgery in prone...
Purpose To explore female college students’ perceived benefits and barriers to cervical cancer screening vulnerability cancer. Method The study was exploratory cross sectional. Pap Smear Belief Questionnaire distributed online a sample of 267 undergraduate baccalaureate nursing students. Findings Students who obtained routine smears greater fewer than the students did not obtain smears. Personal significant finding. were in long-term relationship, non-smoking initiated sexual intercourse at...
Introduction: This study investigated the effect of coronavirus disease 2019 (COVID-19) lockdown on incidence ocular trauma in children. Methods: In this retrospective cohort study, we collected data pediatric patients who presented with emergency department during period (from 22 March, 2020, to 30 May, 2020). addition, presenting same previous year. We compared number underwent surgery and paediatric between these two periods. A confounding factor may be absence from different districts...
Abstract Introduction: This study investigated the effect of coronavirus disease 2019 (COVID-19) lockdown on incidence ocular trauma. Methods: In this retrospective cohort study, we collected data patients who presented with trauma in emergency department during period (from 22 March, 2020, to 30 April, 2020). addition, presenting same previous year. We compared number underwent surgery and paediatric between these two periods. A confounding factor may be absence from different districts...
Abstract Background: Genomic alterations of metastatic cancers may be discordant with in primary tumors due to continuous evolution disease and tumor heterogeneity. Current NGS approaches based on tissue biopsies can fail capture a complete picture the real-time cancer profile. Biopsy-free genomic profiling circulating DNA (ctDNA) provide deep insights into when are not an option. Methods: We developed Guardant360 for comprehensive ctDNA high sensitivity (detection 90%+ advanced pts)...
We present the case of imported malaria in pregnancy to United Kingdom (UK) from Nigeria, where a 28-year-old primigravida presented our maternity assessment unit (MAU) with complaints pyrexia, rigors and passing dark coloured urine. She gave travel history recent migration Nigeria 10 days before presenting emergency department. initially became unwell five after her arrival general malaise myalgia. On day six, she developed lower abdominal pain observed that urine was colour. This prompted...
The main objective of our paper is to design an Automotive Restraint system solve the Biological problems such as DEEP VEIN THROMBOSIS, LEG CRAMPING while driving for long distance journey.The right foot constantly feeding signals accelerator either depressing it more or letting off pressure, split seconds time.And every so often pivoting ball on heel press brake: rest floor, angled up against pedal and last hours depending hours.So Ankle joint, feet, toes are always under stress.This leads...
Introduction: IBD is a common chronic disorder including Crohn’s disease (CD) and ulcerative colitis (UC) these patients frequently get CDI. The burden of CDI on age 65+ has not been fully explored. Our study compares healthcare outcomes in with primary (pCDI) recurrent (rCDI) both without IBD. Methods: This retrospective utilized 2009-2017 100% Medicare Fee-for-Service (FFS) claims to identify ≥ 65 ≥1 episode. Patients were continuously enrolled Parts A, B, D for 12 months before no up...