A5011820923- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Cardiovascular Issues in Pregnancy
- Biomarkers in Disease Mechanisms
- Electrolyte and hormonal disorders
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Evolutionary Psychology and Human Behavior
- Neuroscience of respiration and sleep
- Pain Mechanisms and Treatments
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Gestational Diabetes Research and Management
- Apelin-related biomedical research
- Pregnancy and Medication Impact
- Cardiac Structural Anomalies and Repair
- Uterine Myomas and Treatments
- Metabolism, Diabetes, and Cancer
- Assisted Reproductive Technology and Twin Pregnancy
- Protease and Inhibitor Mechanisms
- Endometriosis Research and Treatment
- Connective tissue disorders research
- Takotsubo Cardiomyopathy and Associated Phenomena
- Atherosclerosis and Cardiovascular Diseases
- Corrosion Behavior and Inhibition
Medical University of Warsaw
2016-2024
Procreation, understood as the production of offspring and continuation a species, is one fundamental life functions for humans, just it other living organisms. For this reason, unresolved issue physiological reproductive disorders has been significant problem humanity thousands years, considering social, psychological, emotional consequences such disorders. In context millennia research into functioning system, July 25, 1978, stands out an unforgettable date in world science. On that day,...
The objective of this study is to evaluate MMP-14 expression in odontoblasts and the bulk dental pulp teeth with pulpitis; determine microRNA-410 (miR-410) tissue, since sequence analysis suggests that miR-410 has potential binding site on MMP-14's 3'UTR, hence, can regulate latter one. Tissue samples from pulpitis healthy (control) were formalin fixed paraffin embedded (FFPE). Samples examined using immunohistochemical staining for was evaluated qRT-PCR. In both, inflamed stained more...
Abstract MicroRNAs are involved in various pathologies including cancer. The aim of the study was to assess level expression miR-96-5p, -134-5p, -181b-5p, -200b-3p FFPE samples prostate cancer, adjacent cancer-free tissue, and benign prostatic hyperplasia. Samples 23 cancer 22 hyperplasias were dissected HE stained. Compartments tumor tissue healthy glandular isolated from each sample using Laser Capture Microdissection. Total RNA tissues. Expression miR-134-5p, 181b-5p, miR-200b-3p...
Gestational diabetes mellitus (GDM) is a metabolic disease diagnosed in 1.7% up to 11.6% pregnancies. The prevalence of adverse pregnancy outcome significantly higher the case early onset mellitus. Adropin hormone promoting carbohydrate oxidation over fat oxidation, and influence nitric oxide synthase. Copeptin cleavage product vasopressin precursor recently correlated with aim study was determine maternal serum adropin copeptin concentrations women late manifestation GDM discuss their...
Based on the available literature, it can be assumed that in cases of post-infarct heart failure (HF) and obesity, a significant change central regulation cardiovascular system takes place with, among others, involvement apelinergic system. The main objective present study was to clarify role apelin-13 Sprague Dawley rats with HF or sham operated (SO) fed normal fat (NFD) high diet (HFD). divided into two parts: Part I, hemodynamic studies; II, biochemical molecular studies. animals were...
Abstract Endometrial cancer (EC) is one of the most common types female reproductive system. EC classified into two (EC1 and EC2). MiRNAs are single-stranded RNA molecules that regulate gene expression posttranscriptionally. They have aberrant profiles in cancer, including EC. This study aimed to assess level a panel 16 miRNAs both healthy endometrium (HE). A total 45 patients were enrolled study, 18 diagnosed with EC1, 12 EC2, 15 HE controls. Tumor tissues or endometrial dissected from...
The search for new materials bone regenerative purposes is still ongoing. Therefore, we present a series of newly constructed composites based on β tricalcium phosphate (βTCP) and poly(3-hydroxybutyrate) bacteria-derived biopolymer (P(3HB)) in the form 3D scaffolds with different pore sizes. To improve polymer attachment to βTCP surface, etching ceramic sinters, using citric acid, was applied. As expected, pre-treatment led increase surface roughness creation micropores facilitating...
Assessment of the plasma concentrations natriuretic peptides (NPs) is widely used to diagnose and evaluate progression cardiac failure, their potential as markers preeclampsia (PE) has been examined in recent years. It established that NPs do not change course normal pregnancy. However, elevated levels these may have a prognostic value patients with PE. This study presents information about relevance assessment evaluation physiological pregnancy, well pregnancy complicated arterial...
The present study aimed to determine whether the presence of cardiac hypertrophy due arterial hypertension is associated with a change in activity oxytocinergic system cardiomyocytes.The experiments were performed on male, spontaneously hypertensive rats (SHR, n = 10) and normotensive Wistar-Kyoto (WKY, 12). Blood samples collected from both SHR WKY animals asses plasma oxytocin (OT) concentration; sacrificed by decapitation. Samples left right ventricles harvested for analysis OT receptor...
Objectives: Adrenomedullin (AM) and natriuretic peptide levels are elevated in pre-eclampsia. The aim of the present study was to determine AM concentrations before 20 weeks pregnancy women who later developed gestational hypertension normal pregnancies. Methods: 95 pregnant Caucasian were included study. Gestational (GH) diagnosed 18 patients. control group consisted 41 patients with pregnancies (non-GH). Blood samples taken during first trimester pregnancy. Results: Analysis NT-proBNP...
Myocardial ischemia that occurs during acute coronary syndrome (ACS) induces a cascade of pathophysiological processes which might lead to left ventricle dysfunction reflected by decreased ventricular ejection fraction (LVEF) in echocardiographic examination. The enzymes regulating extracellular matrix (ECM) like metalloproteinase 9 (MMP-9) also take part this process. MMP-9 activity is under control microRNA particle miR-21, down-regulates its inhibitors. study has shown, ACS population (n...
INTRODUCTION Vulnerable atherosclerotic plaque localized in coronary arterial bed is clinically important, because its rupture leads to a thrombus generation, which can totally occlude the culprit artery causing myocardial infarction. Therefore finding biomarker characteristic for vulnerable warranted. A potential candidate hsa‐miR‐21‐5p, microRNA particle promotes destabilization by increasing MMP‐9 expression and enhancing local inflammatory state (negative regulation of SMAD‐7...
Abstract Endometrial cancer (EC) is one of the most common types female reproductive system. EC classified into two (EC1 and EC2). MiRNAs are single-stranded RNA molecules that regulate gene expression posttranscriptionally. They have aberrant profiles in cancer, including EC. This study aimed to assess level a panel 16 miRNAs both healthy endometrium (HE). A total 45 patients were enrolled study, 18 diagnosed with EC1, 12 EC2, 15 HE controls. Tumor tissues or endometrial dissected from...