A5084650992- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV-related health complications and treatments
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS drug development and treatment
- COVID-19 Clinical Research Studies
- Ethics in Clinical Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Adolescent Sexual and Reproductive Health
- HIV/AIDS Impact and Responses
- Long-Term Effects of COVID-19
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Academic integrity and plagiarism
- Tuberculosis Research and Epidemiology
- HIV, Drug Use, Sexual Risk
- Artificial Intelligence in Healthcare and Education
- SARS-CoV-2 detection and testing
- Breastfeeding Practices and Influences
- Biomedical Ethics and Regulation
- Ethics in medical practice
- Animal Virus Infections Studies
- vaccines and immunoinformatics approaches
- Child Nutrition and Water Access
- Palliative Care and End-of-Life Issues
University of Pretoria
2016-2025
South African Medical Research Council
2020-2024
Steve Biko Hospital
2021-2024
Tshwane University of Technology
2021-2023
Stellenbosch University
2014-2022
University of KwaZulu-Natal
2014-2022
University of Cape Town
2022
Bipar
2020
National Health Laboratory Service
2014-2015
University College London
2014
Abstract The SARS-CoV-2 Omicron variant (B.1.1.529) has multiple spike protein mutations 1,2 that contribute to viral escape from antibody neutralization 3–6 and reduce vaccine protection infection 7,8 . extent which other components of the adaptive response such as T cells may still target severe outcomes is unknown. Here we assessed ability react in participants who were vaccinated with Ad26.CoV2.S or BNT162b2, unvaccinated convalescent COVID-19 patients ( n = 70). Between 70% 80% CD4 +...
Abstract SARS-CoV-2 501Y.V2 (B.1.351), a novel lineage of coronavirus causing COVID-19, contains substitutions in two immunodominant domains the spike protein. Here, we show that pseudovirus expressing protein completely escapes three classes therapeutically relevant antibodies. This also exhibits substantial to complete escape from neutralization, but not binding, by convalescent plasma. These data highlight prospect reinfection with antigenically distinct variants and foreshadows reduced...
The SARS-CoV-2 Omicron variant escapes neutralizing antibodies elicited by vaccines or infection. However, whether triggers cross-reactive humoral responses to other variants of concern (VOCs) remains unknown. We used plasma from 20 unvaccinated and 7 vaccinated individuals infected BA.1 test binding, Fc effector function, neutralization against VOCs. In individuals, function binding targeted VOCs at comparable levels. BA.1-triggered was not extensively for (14- 31-fold titer reduction), we...
Microbial translocation contributes to immune activation and disease progression during chronic human immunodeficiency virus type 1 (HIV-1) infection. However, its role in the African AIDS epidemic remains controversial. Here, we investigated relationship between markers of monocyte activation, plasma lipopolysaccharide (LPS), HIV-1 RNA South Africans prioritized receive combination antiretroviral therapy (cART).Ten HIV-1-negative controls 80 HIV-1-infected patients with CD4 T cell counts...
The use of biological samples in research raises a number ethical issues relation to consent, storage, export, benefit sharing and re-use samples. Participant perspectives have been explored North America Europe, with only few studies reported Africa. amount being conducted Africa is growing exponentially volumes exported from the African continent. In order investigate participants, we study at sites Western Cape Gauteng, South Data were collected using semi-structured questionnaire that...
Summary The SARS-CoV-2 Omicron variant has multiple Spike (S) protein mutations that contribute to escape from the neutralizing antibody responses, and reducing vaccine protection infection. extent which other components of adaptive response such as T cells may still target severe outcomes is unknown. We assessed ability react with spike in participants who were vaccinated Ad26.CoV2.S or BNT162b2, unvaccinated convalescent COVID-19 patients (n = 70). found 70-80% CD4 CD8 cell was maintained...
Abstract Background There is a dearth of information on the prevalence scientific misconduct from Nigeria. Objectives This study aimed at determining in group researchers N igeria. Factors associated with were ascertained. Method A descriptive who attended conference 2010 was conducted using adapted S cientific M isconduct Q uestionnaire‐ R evised ( SMQ‐R ). Results Ninety‐one (68.9%) admitted having committed least one eight listed forms misconduct. Disagreement about authorship most common...
The Janssen (Johnson & Johnson) Ad26.COV2.S non-replicating viral vector vaccine has been widely deployed for COVID-19 vaccination programs in resource-limited settings. Here we confirm that neutralizing and binding antibody responses to are stable 6 months post-vaccination, when tested against multiple SARS-CoV-2 variants. Secondly, using longitudinal samples from individuals who experienced clinically mild breakthrough infections 4 5 after vaccination, show dramatically boosted antibodies,...
Misconduct in research tarnishes the reputation, credibility and integrity of institutions. Studies on or scientific misconduct are still novel developing countries. In this study, we report attitudes, perceptions factors related to work environment thought be associated with a group researchers Nigeria - country. A survey attending conference was done using an adapted Scientific Questionnaire-Revised (SMQ-R). Initial descriptive analysis individual items frequencies proportions for all...
Abstract Neutralization escape by SARS-CoV-2 variants, as has been observed in the 501Y.V2 (B.1.351) variant, impacted efficacy of first generation COVID-19 vaccines. Here, antibody response to variant was examined a cohort patients hospitalized with early 2021 - when over 90% infections South Africa were attributed 501Y.V2. Robust binding and neutralizing titers detected these antibodies showed high levels cross-reactivity for original from wave. In contrast an earlier study where sera...
Consent processes for clinical trials involving HIV prevention research have generated considerable debate globally over the past three decades. cure/eradication is scientifically more complex and consequently, consent in this field are likely to pose a significant challenge. Given that efforts now moving toward eradication, stakeholder engagement inform appropriate ethics oversight of such timely. This study sought establish perspectives wide range stakeholders treatment cure research. In...
Abstract We evaluated immune biomarker profiles in human immunodeficiency virus (HIV)–infected adults (n = 398) from 5 African countries. Although all biomarkers decreased after antiretroviral therapy (ART) initiation, levels of C-X-C chemokine ligand 10 (CXCL10), lipopolysaccharide-binding protein, C-reactive soluble CD163, and scavenger receptor CD14 were significantly higher during ART than an HIV-uninfected reference group 90), indicating persistent monocyte/macrophage activation,...