A5101806193- Cancer, Hypoxia, and Metabolism
- Prostate Cancer Treatment and Research
- Cancer, Lipids, and Metabolism
- Chemokine receptors and signaling
- Boron Compounds in Chemistry
- Flavonoids in Medical Research
- 14-3-3 protein interactions
- Retinal Development and Disorders
- Calpain Protease Function and Regulation
- Advanced Proteomics Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Pain Mechanisms and Treatments
- Ferroptosis and cancer prognosis
- Photoreceptor and optogenetics research
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Immune cells in cancer
- Cytokine Signaling Pathways and Interactions
- Hemoglobin structure and function
- Bioinformatics and Genomic Networks
- Cancer Research and Treatments
Southern Medical University
2025
Nanfang Hospital
2025
First Affiliated Hospital of Jinan University
2020-2024
Nanchang University
2016
Guangzhou Medical University
2013-2014
Guangzhou First People's Hospital
2013-2014
Nanjing Medical University
2013
Wenzhou Medical University
2011
Although the combination of radiotherapy and immunotherapy is regarded as a promising clinical treatment strategy, numerous trials have failed to demonstrate synergistic effects. One key reasons that conventional radiotherapies inevitably damage intratumoral effector immune cells. Boron Neutron Capture Therapy (BNCT) precise selectively kills tumor cells while sparing adjacent normal cells, by utilizing 10B agents neutron irradiation. Therefore, combinational BNCT-immunotherapy holds promise...
Background and Aim . CC chemokine ligand 18 (CCL18) promotes malignant behaviors of various human cancer types. However, its involvement in prostate has not been fully elucidated. The aim this study was to investigate the role CCL18 PCa. Methods Expression at mRNA protein levels detected using real-time qRT-PCR immunohistochemistry analysis. We analyzed associations expression with clinical features effects PCa cell migration, invasion, apoptosis were tested. efficiency on tumor growth...
Aim Early diagnosis of prostate cancer (PCa), which is a clinically heterogeneous-multifocal disease, essential to improve the prognosis patients. However, published PCa diagnostic markers share little overlap and are poorly validated using independent data. Therefore, we here developed an integrative proteomics interaction network-based classifier by combining differential protein expression with topological features human networks enhance ability diagnosis. Methods Results By...
Citrate synthase (CS) is a rate-limiting enzyme in the citrate cycle and capable of catalyzing oxaloacetate acetyl-CoA to citrate. CS has been uncovered be upregulated variety cancers, its expression clinical significance prostate cancer (PCa) remain unknown.In this study, we examined association between level clinicopathological features patients TMA cohort public database (The Cancer Genome Atlas-Prostate Adenocarcinoma, TCGA-PRAD). The knockdown cell lines were constructed study effects...
Lactate dehydrogenase isozyme (LDH) is a tetramer constituted of two isoforms, LDHA and LDHB, the expression which associated with cell metabolism cancer progression. Our previous study reveals that CC-chemokine ligand-18 (CCL18) involved in progression prostate (PCa).This aims to investigate how CCL18 regulates LDH isoform expression, therefore, contributes PCa The data revealed was upregulated LDHB downregulated cells by at both messenger RNA protein levels. depletion CCR8 reduced ability...
Advanced prostate cancer (PCa) often initially responds to androgen receptor signaling inhibitors (ARSI) but frequently develops resistance, driven by tumor heterogeneity and therapeutic pressure. Addressing the clinical challenge of identifying non-responsive patients discovering new targets is urgently needed. We utilized single-sample gene set enrichment analysis (ssGSEA) elucidate influence GG-NER pathway on ARSI response in PCa. then constructed validated a prognostic model based this...
Retinitis pigmentosa (RP) is a group of inherited retinal degeneration diseases characterized by photoreceptor cell death that causes visual disturbances and eventual blindness. Intraperitoneal injection N-methyl-N-nitrosourea (MNU) loss, used to create an animal model for investigating the mechanisms cause diseases. Donepezil acetylcholinesterase inhibitor has protective effect on ganglion cells in vitro vivo, it understood donepezil increases expression heat shock protein 70 (Hsp70), which...
Objective To establish the green fluorescent protein (GFP) + bone marrow reconstituted nude mice model.Methods Different doses (4,6,8,10 Gy) X-ray were used to irradiate mice.The hemogram was detected separately 1,3,5,7,14 and 21 days after irradiation in order confirm proper dose for damage.One-week with such dose,allogeneic transplantation GFP cells (BMCs) (2 × 107 cells/mice) executed through caudal vein.The proportion of donor peripheral blood tested.White (WBCs) BMCs compared before...
Objective To investigate the effect of curcumin on apoptosis in spinal cord and dorsal root ganglion neurons a rat model diabetic neuropathic pain (DNP) . Methods One hundred eight male SD rats weighing 200-230 g were randomly divided into 4 groups ( n = 27 each): control group (group C), DNP group, solvent SC) Cur) Diabetes was induced with intraperitoneal streptozocin 70 mg/kg. Successful induction diabetes defined as blood glucose ＞ 16.7 mmol/L. Curcumin com oil 100 mg/kg (23 mg/ml) given...