A5101832057- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- RNA modifications and cancer
- Spinal Cord Injury Research
- Sesquiterpenes and Asteraceae Studies
- Prostate Cancer Treatment and Research
- Cancer, Lipids, and Metabolism
- Wnt/β-catenin signaling in development and cancer
- Bladder and Urothelial Cancer Treatments
- Hematopoietic Stem Cell Transplantation
- Chemokine receptors and signaling
- Epigenetics and DNA Methylation
- Kruppel-like factors research
- Natural Compounds in Disease Treatment
- Fatigue and fracture mechanics
- Mechanisms of cancer metastasis
- Bioactive natural compounds
- Bioactive Compounds and Antitumor Agents
- Bacterial Genetics and Biotechnology
- Abdominal Surgery and Complications
- Ferroptosis and cancer prognosis
- Musculoskeletal pain and rehabilitation
First Affiliated Hospital of Jinan University
2012-2024
Zhejiang Chinese Medical University
2024
Shanghai Ninth People's Hospital
2023
Shanghai Jiao Tong University
2023
Xuzhou Medical College
2010-2023
Jiangsu University
2021-2023
Soochow University
2023
First Affiliated Hospital of Soochow University
2023
Affiliated Hospital of Jiangsu University
2023
First Affiliated Hospital of Chengdu Medical College
2020
Abstract Solanine, a naturally steroidal glycoalkaloid in nightshade (Solanum nigrum Linn.), can inhibit proliferation and induce apoptosis of tumor cells. However, the mechanism solanine‐suppressing prostate cancer cell growth remains to be elucidated. This study investigates inhibition solanine on development vivo cultured human DU 145 vitro. Results show that injection significantly suppresses xenograft athymic nude mice. Solanine regulates protein levels cycle proteins, including Cyclin...
Phosphatidylinositol 3-kinase (PI3K)/AKT and mitogen activated protein kinase (MAPK) signaling cascades have significant roles in cell proliferation, survival, angiogenesis metastasis of tumor cells. Eupatilin, one the major compounds present
Increasing evidence indicates that immunoglobulins are important for the regulation of various cancers including prostate cancer (PCa). However, underlying mechanisms IgG regulated PCa development remain to be further explored. Here, we demonstrated IgG1 heavy chain (IGHG1) was increased in tissues from patients. Inhibition IGHG1 by antibody blocking or genetic knockdown suppressed cell growth and induced cycle arrest ultimate apoptosis. Expression levels c-Myc were positively correlated...
Abstract Spinal cord injury (SCI) is a highly severe disease and it can lead to the destruction of motor sensory function resulting in temporary or permanent disability. Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nt that play critical role central nervous system (CNS) injury. However, exact roles lncRNAs messenger (mRNAs) early acute phase SCI remain be elucidated. We examined expression mRNAs rat model at 2 days after identified differentially expressed (DE lncRNAs)...
Low back pain is usually caused by intervertebral disc degeneration (IVDD), during which the involvement of oxidation system imbalance and inflammasome activation cannot be neglected. In this study, we aimed to validate expression level TXNIP in IVDD investigate function potential mechanism action verapamil. upregulated degenerate nucleus pulposus both humans rats, as well tert-butyl hydroperoxide (TBHP)-stimulated cells. Administration verapamil, a classic clinical drug, mitigated...
Long non-coding RNAs (lncRNAs) are widely accepted as key players in various biological processes. However, the roles of lncRNA peripheral nerve regeneration remain completely unknown. Thus, this study, we performed microarray analysis to measure expression distal segment sciatic at 0, 3, 7 and 14 days following injury. We identified 5,354 lncRNAs that were differentially expressed: 3,788 expressed between 0 3; 3,314 7; 2,400 14. The results RT-qPCR two dysregulated consistent with those...
Schwann cells play a critical role in peripheral nerve regeneration through dedifferentiation and proliferation. In previous study, we performed microarray analysis of the sciatic after injury. Accordingly, predicted that long non-coding RNA NONMMUG014387 may promote cell proliferation injury, as bioinformatic revealed target gene was collagen triple helix repeat containing 1 (Cthrc1). Cthrc1 variety by activating Wnt/PCP signaling. Nonetheless, still needs to be verified biological...
Prostate cancer is the most common malignant tumor of urinary system. The mechanisms initiation and progression prostate have not been fully elucidated. Increasing evidence suggests that circular RNAs (circRNAs) are involved in pathogenesis. In this study, we aimed to identify differentially expressed circRNAs tissues explored role pathogenesis cancer. By screening a circRNA microarray assay, found circ_0088233 was upregulated compared adjacent normal tissues, upregulation can be verified 46...
Non-coding RNAs play an important role in the pathogenesis of prostate cancer (PC). This study aims to characterize GAS5 rs145204276 and HOTAIR rs4759314 polymorphisms PC. Both INS allele A were identified increase survival PC patients. And patients carrying DEL/DEL + AG genotypes tend present higher levels HMGB1, GAS5, lower miR-1284 miR-22. In addition, transcription activity promoter was increased by deletion polymorphism, while G polymorphism promoter. could bind miR-22, respectively,...
Research has shown that long-chain noncoding RNAs (lncRNAs) are involved in the regulation of a variety biological processes, including peripheral nerve regeneration, part by acting as competing endogenous RNAs. c-Jun plays key role repair injury. However, precise underlying mechanism remains unclear. In this study, we performed microarray and bioinformatics analysis mouse crush-injured sciatic nerves found lncRNA Pvt1 was overexpressed Schwann cells after Mechanistic studies revealed...
A binding site for integration host factor (IHF) was identified upstream of the aceBAK promoter. Under inducing conditions, IHF activates aceB::lacZ expression by opposing IclR repression. In contrast, has little effect on under repressing conditions. The ability to relieve repression but not conditions allows this protein amplify induction aceBAK.
Lactate dehydrogenase isozyme (LDH) is a tetramer constituted of two isoforms, LDHA and LDHB, the expression which associated with cell metabolism cancer progression. Our previous study reveals that CC-chemokine ligand-18 (CCL18) involved in progression prostate (PCa).This aims to investigate how CCL18 regulates LDH isoform expression, therefore, contributes PCa The data revealed was upregulated LDHB downregulated cells by at both messenger RNA protein levels. depletion CCR8 reduced ability...
LncRNAs involve in the autophagy to regulate prostate cancer (PCA) initiation and progression. Therefore, it urges explore more significant AR-lncRNAs PCa. mRNA data clinical information of PCa were achieved from TCGA database, ARGs obtained HADb. identified by correlation analysis DE lncRNAs. Univariate Cox regression, LASSO multivariate regression used identify prognostic AR-lncRNA signature constructed a risk model. GESA was biological function between high- low-risk score group. A...
Upregulated gene 11 (URG11), a new upregulated by hepatitis B virus X protein, is involved in the development and progression of several tumors, including liver, stomach, lung, colon cancers. However, role URG11 prostate cancer remains yet to be elucidated. By determined expression human tissues, was found significantly positively correlated with severity cancer, compared that benign prostatic hyperplasia tissues. Further, mRNA protein levels were cell lines (DU145, PC3, LNCaP), epithelial...
Abstract Background Triosephosphate isomerase 1 (TPI1), as a widely involved glycolytic enzyme, plays significant role in glucose metabolism and is highly expressed various tumors. However, its lung adenocarcinoma (LUAD) remains incompletely understood. Methods Through bioinformatic analysis, we identified positive association between high expression of TPI1 metastasis LUAD. Western blot, RT‐qPCR, wound healing assays transwell experiments, were employed to investigate potential mechanisms....
In recent years, nanotechnology has made great progress in the development and application of tumor detection, diagnosis, treatment, eventually formed a “tumor nanomedicine.” The emerging field “materials.” Nanoparticles have attracted much attention because they can overcome physiological barriers, effectively deliver hydrophobic drugs, specifically target tissues. At present, nanomedicines mainly include lipid nanoparticles, polymer nanoparticles granules, gold magnetic mesoporous silica,...