Heart failure (HF) is a prevalent age-related cardiovascular disease with poor prognosis in the elderly population. This study aimed to establish causal relationship between ageing and HF by conducting bidirectional Mendelian randomization (MR) analysis on epigenetic age (a marker of ageing) HF.

// Xiaoping Wu 1 , Tianchi Liu Ou Fang Wenhua Dong Fengjun Zhang Lindsey Leach 2 Xiaohua Hu Zewei Luo 1, Laboratory of Population and Quantitative Genetics, Institute Biostatistics, State Key Genetic Engineering, School Life Sciences, Fudan University, Shanghai, China Biosciences, University Birmingham, UK Correspondence to: Luo, e-mail: z.luo@bham.ac.uk Hu, xhhu@fudan.edu.cn Keywords: non-small cell lung cancer, therapeutic agent, MicroRNA-708-5p, metastasis, p21 Received: August 10,...

Osteoporosis (OP) is a significant disease in the aging society, which poses threat to physical well-being of older adults. Some studies suggest that air pollution may contribute an increased incidence OP; however, this causal relationship has not been firmly established. To address gap, we conducted Mendelian randomization (MR) analysis assess potential association between (including nitrogen dioxide [N = 456,380], oxides particulate matter [PM]2.5 423,796], and PM10 455,314]) total-body...

The areas with typical municipal sewage discharge river and irrigation water function were selected as study sites in northeast China. samples from groundwater sediment this area collected for the concentrations forms of heavy metals (Cr(VI), Cd, As, Pb) analysis. risk assessment metal pollution was conducted based on single-factor index (I) Nemerow (NI). results showed that only one sampling site reached a polluted level metals. There high potential ecological Cd N21-2 sediment....

There is growing evidence of a strong relationship between COVID-19 and myocarditis. However, there are few bioinformatics-based analyses critical genes the mechanisms related to Myocarditis. This study aimed identify Myocarditis by bioinformatic methods, explore biological gene regulatory networks, probe drugs.The expression data GSE150392 GSE167028 were obtained from Gene Expression Omnibus (GEO), including cardiomyocytes derived human induced pluripotent stem cells infected with...

Observational studies suggest that cardiovascular disease (CVD) increases the risk of developing Alzheimer's (AD). However, causal relationship between two is not clear. This study applied a two-sample bidirectional Mendelian randomization method to explore CVD and AD. Genome-wide association (GWAS) data from 46 datasets European populations (21,982 cases AD 41,944 controls) were utilized obtain genetic instrumental variables for In addition, atrial fibrillation (AF), heart failure (HF),...

Abstract Dilated cardiomyopathy (DCM) is a condition of impaired ventricular remodeling and systolic diastole that often complicated by arrhythmias heart failure with poor prognosis. This study attempted to identify autophagy-related genes (ARGs) diagnostic biomarkers DCM using machine learning bioinformatics approaches. Differential analysis whole gene microarray data from the Gene Expression Omnibus (GEO) database was performed NetworkAnalyst 3.0 platform. Differentially expressed (DEGs)...

To effectively analyze the increasing amounts of available genomic data, improved comparative analytical tools that are accessible to and applicable by a broad scientific community essential. We built “2-n-way” software suite provide fundamental innovative processing framework for revealing comparing inserted elements among various genomes. The comprises two user-friendly web-based modules. 2-way module generates pairwise whole-genome alignments target query species. resulting genome...

Abstract Retrophylogenomics makes use of genome-wide retrotransposon presence/absence insertion patterns to resolve questions in phylogeny and population genetics. In the genomics era, evaluating high-throughput data requires associated development appropriately powerful statistical tools. The currently used KKSC 3-lineage test for estimating significance retrophylogenomic is limited by number possible tree topologies it can assess one step. To improve on this, we have extended analysis...

Summary Dissecting the genetic architecture of quantitative traits is a crucial goal for efficient breeding polyploid plants, including autotetraploid crop species, such as potato and coffee, ornamentals rose. To meet this goal, model needed to link effects genes or genotypes at trait loci (QTL) phenotype traits. We present statistically tractable autotetraploids based on orthogonal contrast comparisons in general linear model. The new methods are suitable species with any population...

Summary Dissecting the genetic architecture of quantitative traits in autotetraploid species is a methodologically challenging task, but pivotally important goal for breeding globally food crops, including potato and blueberry, ornamental such as rose. Mapping trait loci (QTLs) now routine practice diploid far less advanced autotetraploids, largely due to lack analytical methods that account complexities tetrasomic inheritance. We present novel likelihood‐based method QTL mapping outbred...

To evaluate efficacy of intravitreal ranibizumab (IVR) therapy for aggressive posterior retinopathy prematurity (ROP), threshold ROP disease and type 1 pre-threshold ROP.A retrospective analysis was performed on 40 patients (76 eyes) who had IVR as the primary treatment from April 2017 to January 2018. According pathogenic features, 76 eyes were divided into three groups: (AP-ROP) group (16 eyes), (28 (32 eyes). The characteristics lesions situation before first injection, posttreatment...

This optimized approach provides both a computational tool and library construction protocol, which can maximize the number of genomic sequence reads that uniformly cover plant genome minimize representing chloroplast DNA rRNA genes. One implement developed to feasibly design their own RAD-seq experiment achieve expected coverage variant markers for large populations using information ideally, though not necessarily, polymorphism distribution in genome. Advent next generation sequencing...

Dong, Y.; Zhang, F., and Fu, L., 2019. Ecological design: The role of extended producer responsibility system. In: Guido-Aldana, P.A. Mulahasan, S. (eds.), Advances in Water Resources Exploration. Journal Coastal Research, Special Issue No. 93, pp. 354–361. Coconut Creek (Florida), ISSN 0749-0208.With the development society, terrestrial marine ecosystems are destroyed seriously. To protect ecosystems, ecological design is key factor to implement system (EPR), which can effectively improve...

Abstract Here, we report a genome-wide survey of immunoglobulin light chain (IGL) genes torafugu ( Takifugu rubripes ) revealing multi-clusters spanning three separate chromosomes (v5 assembly) and 45 scaffolds (v4 assembly). Conventional sequence similarity searches motif scanning approaches based on recombination signal (RSS) motifs were used. We found that IGL isotypes (L1, L2, L3) exist in several loci for each isotype are present. The transcriptional orientations the variable (V L...

Polyploidy plays an important role in the evolution of eukaryotes, especially for flowering plants. Many ecologically or agronomically plant crop species are polyploids, including sycamore maple (tetraploid), world second and third largest food crops wheat (hexaploid) potato (tetraploid) as well economically aquaculture animals such Atlantic salmon trout. The next generation sequencing data enables to allocate genotype at a sequence variant site, known genotyping by (GBS). GBS has stimulated...