A5005412393- Cardiac Imaging and Diagnostics
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Immune cells in cancer
- Lung Cancer Research Studies
- Acute Myeloid Leukemia Research
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Advanced X-ray and CT Imaging
- Radiation Dose and Imaging
- Acute Myocardial Infarction Research
- Cancer-related Molecular Pathways
- Chemokine receptors and signaling
- Advanced MRI Techniques and Applications
- Cancer Genomics and Diagnostics
- Cardiac tumors and thrombi
- Infective Endocarditis Diagnosis and Management
- CAR-T cell therapy research
- Cytokine Signaling Pathways and Interactions
- Coronary Interventions and Diagnostics
- Immune Cell Function and Interaction
- Protease and Inhibitor Mechanisms
- Glutathione Transferases and Polymorphisms
- Immunotherapy and Immune Responses
- Vascular Tumors and Angiosarcomas
University of Washington
2012-2024
University of Rochester Medical Center
2023
North Shore University Hospital
2022
Bristol-Myers Squibb (United States)
2021
AstraZeneca (Sweden)
2018
Seattle Institute for Biomedical and Clinical Research
2017
Fred Hutch Cancer Center
2011-2016
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2013-2014
University of Chicago
2010
Ludwig-Maximilians-Universität München
2006-2007
Abstract The response rate to immune checkpoint inhibitor therapy for non-small-cell lung cancer (NSCLC) is just 20%. To improve this figure, several early phase clinical trials combining novel immunotherapeutics with blockade have been initiated. Unfortunately, these designed without a strong foundational knowledge of the landscape present in NSCLC. Here, we use flow cytometry panel capable measuring 51 cell populations comprehensively identify composition and function results show that...
Epigenetic alterations, particularly in DNA methylation, are ubiquitous cancer, yet the molecular origins and consequences of these alterations poorly understood. CTCF, a DNA-binding protein that regulates higher-order chromatin organization, is frequently altered by hemizygous deletion or mutation human cancer. To date, causal role for CTCF cancer has not been established. Here, we show Ctcf knockout mice markedly susceptible to spontaneous, radiation-, chemically induced broad range...
Purpose: The aim of this study was to evaluate the diagnostic accuracy dual-source computed tomography (DSCT) with reference invasive coronary angiography in diagnosis artery disease (CAD) on a per-patient as well per-segment basis. Materials and Methods: Thirty-five patients known or suspected CAD underwent both DSCT (Somatom Definition, Siemens Medical Solutions) quantitative x-ray (QCA). Parameters CT acquisition were gantry rotation time 0.330 seconds (ie, temporal resolution 83...
Abstract Lung cancer, the leading cause of cancer-related deaths worldwide, is a heterogeneous disease comprising multiple histologic subtypes that harbor disparate mutational profiles. Immune-based therapies have shown initial promise in treatment lung cancer patients but are limited by low overall response rates. We sought to determine whether host immune dictated, at least part, and genetic differences, because such correlations would important clinical ramifications. Using mouse models...
Chronic obstructive pulmonary disease (COPD) and non-small cell lung cancer (NSCLC) are interrelated diseases with substantial mortality, the pathogenesis of both involves aberrant immune functioning.
Abstract Stromal cells are critical regulators of hematopoietic stem/progenitor and skeletal homeostasis. Although precise systems for functional analysis to investigate mechanistically bone marrow-derived stromal cells, the establishment reproducible, highly enriched ex vivo methods cell isolation, culture evaluation have been challenging, leading inconsistent data on function. In this work, we carefully tested murine from marrow discovered abundant persistent contamination monocytes...
The metameric organization of the insect body plan is initiated with activation gap genes, a set transcription-factor-encoding genes that are zygotically expressed in broad and partially overlapping domains along anteroposterior (AP) axis early embryo. spatial pattern gene expression AP generally conserved, but maternal regulate their not. Building on comprehensive knowledge Drosophila, we used loss- gain-of-function experiments hover fly Episyrphus balteatus (Syrphidae) to address question...
Significance Kirsten rat sarcoma viral oncogene homolog ( KRAS ) mutant lung adenocarcinoma remains an intractable cancer subtype for which efficacious targeted therapies do not exist. This study identified a subpopulation of with reduced insulin receptor substrate-1 (IRS-1) content and showed that this group is particularly amenable to Janus kinase/signal transducers activators transcription (JAK/STAT) inhibition. finding the first definitive report prohost role IRS-1 in solid tumor...
Objective: Pediatric patients represent low frequency but potentially high-risk encounters for emergency medical services (EMS) providers. Scant information is available from EMS agencies on the of pediatric skill evaluation and presence care coordination, both which may help systems optimize children. The objective our study was to assess type methods used psychomotor skills competency using pediatric-specific equipment coordination in ground transport agencies. Methods: A web-based...
Abstract Hepatic haemangiosarcoma is a deadly malignancy whose aetiology remains poorly understood. Inactivation of the CDKN2A locus, which houses ARF and p 16 INK 4 tumour suppressor genes, common event in patients, but precise role vascular tumourigenesis unknown. To determine extent to suppresses neoplasia, we examined incidence hepatic lesions Arf ‐deficient mice exposed carcinogen urethane [intraperitoneal (i.p.), 1 mg/g]. Loss resulted elevated morbidity increased both haemangiomas...
Abstract Despite decades of research, non-small cell lung carcinoma (NSCLC) remains one the world's deadliest cancers. Approximately half NSCLC cases are classified as adenocarcinomas (ADCA), in which KRAS, EGFR, and TP53 mutations predominant genetic drivers. Although patients with EGFR initially responsive to targeted therapies, drug resistance uniformly occurs within year. KRAS mutant ADCA have proven even more intractable, scant progress has been made development therapeutics for this...
Ziel: Myxoma des linken Atriums sind eine seltene Diagnose. Zufallsbefunde meist Ergebnis einer transthorakalen Echokardiografie. Kontrastmittelverstärkter Ultraschall verspricht neue Möglichkeiten für Diagnose und präoperative Behandlung von Patienten mit Myxoma. Als zusätzliche Untersuchung kann kontrastmittelverstärkter die Ergebnisse CT oder MRT stützen bestätigen. Material Methoden: Wir berichten 63-jährigen Patientin Myxom im Atrium, in deren Fall durch kontrastmittelverstärkten...