A5035106383- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Nicotinic Acetylcholine Receptors Study
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Ion channel regulation and function
- Mental Health Research Topics
- Pain Mechanisms and Treatments
- Eating Disorders and Behaviors
- Biochemical and Structural Characterization
- Infant Health and Development
- Obesity and Health Practices
- Neural dynamics and brain function
- Advanced Chemical Sensor Technologies
- Neurosurgical Procedures and Complications
- Neuroscience and Neural Engineering
- Autism Spectrum Disorder Research
- Advanced Drug Delivery Systems
- Tryptophan and brain disorders
- Child Nutrition and Feeding Issues
- Inflammatory mediators and NSAID effects
- Intracerebral and Subarachnoid Hemorrhage Research
First Pavlov State Medical University of St. Petersburg
2000-2021
University of Helsinki
2008-2019
Biomed Research Institute
2012
Helsinki University Hospital
2009
University of Turku
1999-2004
Tampere University
2000-2001
The TASK-3 channel is an acid-sensitive two-pore-domain K<sup>+</sup> channel, widely expressed in the brain and probably involved regulating numerous neuronal populations. Here, we characterized behavioral pharmacological phenotypes of knockout (KO) mice. Circadian locomotor activity measurements revealed that nocturnal KO mice was increased by 38% (<i>P</i> < 0.01) compared with wild-type littermate controls, light phase being similar. Although channels are abundant cerebellar granule...
The importance of AMPA-type glutamate receptors has been demonstrated in neuronal plasticity and adaptation to drugs abuse. We studied the involvement AMPA social interaction anxiety found that several paradigms agonistic behavior naïve male mice deficient for GluR-A subunit- containing are less aggressive than wild-type littermates. littermates exhibited similar basic reflexes as monitored by observational Irwin's test, but they tended be anxious elevated plus-maze light-dark tests....
AMPA-type glutamate receptors have been suggested to be involved in the neurobiological mechanisms of drug addiction. We made use two mouse lines, which both modulated AMPA receptor responses. The first line is entirely deficient receptor-A (GluR-A) subunits (A−/− knock-out line) and, second one, Q582 residue GluR-A replaced by an arginine (R/R mutants), reduces calcium permeability and channel conductance containing this mutated subunit. Mice lines are healthy, but they show slightly...
Abstract Benzodiazepine‐ and alcohol‐induced ataxias in rodents have been proposed to be affected by the γ‐aminobutyric acid type A (GABA ) receptor α6 subunit, which contributes receptors specifically expressed cerebellar granule cells. We studied an –/– mouse line for motor performance drug sensitivity. These mice, as a result of specific genetic lesion, carry precise impairment at their Golgi‐granule cell synapses. On tests (rotarod, horizontal wire, pole descending, staircase swimming...
Inhalation anesthetics activate and cannabinoid agonists inhibit TWIK-related acid-sensitive K<sup>+</sup> channels (TASK)-1 two-pore domain leak in vitro. Many neuromodulators, such as noradrenaline, might also manifest some of their actions by modifying TASK channel activity. Here, we have characterized the basal behavioral phenotype TASK-1 knockout mice tested sensitivity to inhalation halothane isoflurane, α<sub>2</sub> adrenoreceptor agonist dexmedetomidine, WIN55212-2 mesylate...
Dopamine neurons of the ventral tegmental area (VTA) are involved at early phases drug addiction. Even first in vivo dose various abused drugs induces glutamate receptor plasticity excitatory synapses these neurons. Benzodiazepines that suppress inhibitory GABAergic interneurons VTA via facilitation synaptic GABA A receptors have induced neuroplasticity dopamine due to this disinhibitory mechanism. Here, we tested a non-benzodiazepine direct site agonist 4,5,6,7-tetrahydroisoxazolol[4,5- c...
Abstract The gabapentinoid pregabalin is a rapid‐acting anxiolytic and analgesic, possibly suitable in supervised opioid detoxification. However, clinicians have been cautious using it because of its unknown addictive risk rising number mortalities after self‐medication abusers. Here, we studied interactions morphine on reward functions the dopamine system mice efficacy withdrawal addicts. After treatment with morphine, used electrophysiology to study neuroplasticity midbrain slices,...
Abnormal excitatory glutamate neurotransmission and plasticity have been implicated in schizophrenia affective disorders. Gria1−/− mice lacking GluA1 subunit (encoded by Gria1 gene) of AMPA-type receptor show robust novelty-induced hyperactivity, social deficits heightened approach features, suggesting that they could be used to test for anti-manic activity drugs. Here, we tested the efficacy chronic treatment with established drugs on behavioural properties mice. The received standard mood...
Intracerebral hemorrhage (ICH) has a high mortality rate and leaves most survivors disabled. The dismal outcome is mostly due to the mass effect of hematoma plus edema. Major clinical trials show no benefit from surgical or medical treatment. Decompressive craniectomy has, however, proven beneficial for large ischemic brain infarction with massive swelling. We hypothesized that can improve ICH as well.We used model autologous blood injection into basal ganglia in rats. After induction then...
We investigated the behavioral significance of fast synaptic inhibition by αβγ2-type GABAA receptors on parvalbumin (Pv) cells. The receptor γ2 subunit gene was selectively inactivated in Pv-positive neurons Cre/loxP recombination. resulting Pv-Δγ2 mice were relatively healthy first postnatal weeks; but then as Cre started to be expressed, progressively developed wide-ranging phenotypic alterations including low body weight, motor deficits and tremor, decreased anxiety levels, pain...
Abstract Drugs of abuse induce widespread synaptic adaptations in the mesolimbic dopamine (DA) neurons. Such drug‐induced neuroadaptations may constitute an initial cellular mechanism eventually leading to compulsive drug‐seeking behavior. To evaluate impact GABA B receptors on addiction‐related persistent neuroplasticity, we tested ability orthosteric agonist baclofen and two positive allosteric modulators (PAMs) suppress ventral tegmental area (VTA) reward‐related behaviors induced by...
In state-dependency, information retrieval is most efficient when the animal in same state as it was during acquisition. State-dependency has been implicated a variety of learning and memory processes, but its mechanisms remain to be resolved. Here, mice deficient AMPA-type glutamate receptor GluA1 subunits were first conditioned morphine (10 or 20 mg/kg s.c. eight sessions over four days) using an unbiased procedure, followed by testing for place preference at states that different from one...
Milk proteins are the main components of everyday feeding and demonstrate a promising potential to change mental condition. However, effects milk after prolonged use remain poorly understood. The aim present study was compare two whey (α-lactalbumin (α-lac) native whey) with casein on social individual behaviour in mice. During 30 d-long dietary intervention, male C57BL/6J mice had ad libitum access an experimental diet containing 17 % (w/w) one three protein sources: α-lac, or casein. Mice...
Abstract GABA A receptors mediate fast phasic inhibitory postsynaptic potentials and participate in slower tonic extrasynaptic inhibition. Thy1α6 mice with ectopic forebrain expression of receptor α6 subunits exhibit increased receptor‐mediated background conductance reduced synaptic currents hippocampal CA1 neurons [W. Wisden et al . (2002) Neuropharmacology 43, 530–549]. Here we demonstrate that isolated these showed furosemide‐sensitivity GABA‐evoked currents, confirming the functional...
Abstract Background Eating Disorders pose a serious health risk to individuals. Often, eating disorder symptoms are overlooked when assessing obesity risk. The current cross-sectional study was focused on the search of association between disordered behaviors evaluated by Attitudes Test 26 (EAT-26) and in large cohort Russian-speaking adults seeking online assistance with medical weight correction. Methods web-based data completed 13,341 registered adult visitors loss clinic website. EAT-26...