A5024601329- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Ion channel regulation and function
- Alcoholism and Thiamine Deficiency
- Amino Acid Enzymes and Metabolism
- Metabolism and Genetic Disorders
- Folate and B Vitamins Research
- Neural dynamics and brain function
- Drug Transport and Resistance Mechanisms
- Genetic Neurodegenerative Diseases
- Lipid Membrane Structure and Behavior
- Neuroscience and Neural Engineering
- GABA and Rice Research
- Pharmacological Effects and Toxicity Studies
University of Insubria
2021-2024
Abstract The Excitatory Amino Acid Transporter 2 (EAAT2) accounts for 80% of brain glutamate clearance and is mainly expressed in astrocytic perisynaptic processes. EAAT2 function finely regulated by endocytic events, recycling to the plasma membrane degradation. Noteworthy, deficits have been associated with neuronal excitotoxicity neurodegeneration. In this study, we show that trafficking impaired leucine-rich repeat kinase (LRRK2) pathogenic variant G2019S, a common cause late-onset...
Synthesized in the liver from cholesterol, bile acids (BAs) primary role is emulsifying fats to facilitate their absorption. BAs can cross blood-brain barrier (BBB) and be synthesized brain. Recent evidence suggests a for gut-brain signaling by modulating activity of various neuronal receptors transporters, including dopamine transporter (DAT). In this study, we investigated effects relationship with substrates three transporters solute carrier 6 family. The exposure obeticholic acid (OCA),...
Among the most prevalent neurological disorders, epilepsy affects about 1% of population worldwide. We previously found, using human epileptic tissues, that GABAergic neurotransmission impairment is a key mechanism drives pathological phenomena ultimately lead to generation and recurrence seizures. Using both “microtransplantation technique” synaptosomes preparations from drug-resistant temporal lobe epilepsies (TLEs), we used technique two-electrode voltage clamp record GABA-evoked...
Neurotransmitter transporters (NTTs) control synaptic responses by modulating the concentration of neurotransmitters at cleft. Glutamate is most abundant excitatory neurotransmitter in brain and needs to be finely tuned time space maintain a healthy precise neurotransmission. The glutamate transporter EAAT2 (SLC1A2) primarily responsible for clearance. impairment has been associated with Alzheimer's disease (AD), Huntington's (HD), amyotrophic lateral sclerosis (ALS), Parkinson's (PD)....
Abstract The Excitatory Amino Acid Transporter 2 (EAAT2) accounts for 80 % of brain glutamate clearance and is mainly expressed in astrocytic perisynaptic processes. EAAT2 function finely regulated by endocytic events, recycling to the plasma membrane degradation. Noteworthy, deficits have been associated with neuronal excitotoxicity neurodegeneration. In this study, we show that trafficking impaired leucine-rich repeat kinase (LRRK2) pathogenic variant G2019S, a common cause late-onset...
The role of betaine in the liver and kidney has been well documented, even from cellular molecular point view. Despite literature reporting positive effects supplementation Alzheimer’s, Parkinson’s, Schizophrenia, function brain are little studied reviewed. Beneficial neurodegeneration, excitatory Inhibitory imbalance, oxidative stress central nervous system have collected analyzed with aim understanding main brain. There many “dark” aspects needed to complete picture. how this osmolyte is...
Parkinson's disease (PD) is a common chronic and progressive neurodegenerative disorder characterized by complex physiopathology. Although several known causes lead to the onset of disease, central role has been attributed excitotoxicity subsequent cellular damages. Glutamate-mediated excitatory synaptic signalling mainly directed amino acid transporter 2 (EAAT2), localized on astrocyte plasma membrane involved in glutamate clearance. Alterations function or expression EAAT2 extracellular...