A5087559909- Climate variability and models
- Arctic and Antarctic ice dynamics
- Atmospheric and Environmental Gas Dynamics
- Phosphodiesterase function and regulation
- Oceanographic and Atmospheric Processes
- Meteorological Phenomena and Simulations
- Climate change and permafrost
- Receptor Mechanisms and Signaling
- Atmospheric Ozone and Climate
- Tropical and Extratropical Cyclones Research
- Medical Imaging Techniques and Applications
- Marine and coastal ecosystems
- Cryospheric studies and observations
- Cholinesterase and Neurodegenerative Diseases
- Advanced Radiotherapy Techniques
- Nuclear Physics and Applications
- Radiomics and Machine Learning in Medical Imaging
- Geophysics and Gravity Measurements
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Wnt/β-catenin signaling in development and cancer
- Neuropeptides and Animal Physiology
- Bipolar Disorder and Treatment
- Ocean Waves and Remote Sensing
- Alzheimer's disease research and treatments
Hokkaido University
2021-2025
Bjerknes Centre for Climate Research
2015-2024
University of Bergen
2015-2024
Public Works Research Institute
2019
Institute of Genetics and Cancer
2012-2018
University of Edinburgh
2007-2018
Earth Science Institute of the Slovak Academy of Sciences
2017
The University of Tokyo
2002-2012
Medical Research Council
2012
Edinburgh College
2008
Abstract Wide disagreement among individual modeling studies has contributed to a debate on the role of recent sea ice loss in Arctic amplification global warming and Siberian wintertime cooling trend. We perform coordinated experiments with six atmospheric general circulation models forced by observed climatological daily concentration surface temperature. The results indicate that impact decline is rather limited high‐latitude lower troposphere winter, changes do not significantly lead...
Abstract Starting to resolve the oceanic mesoscale in climate models is a step change model fidelity. This study examines how certain obstinate biases midlatitude North Atlantic respond increasing resolution (from 1° 0.25° ocean) and such sea surface temperature (SST) affect atmosphere. Using multimodel ensemble of historical simulations run at different horizontal resolutions, it shown that severe cold SST bias central Atlantic, common many ocean models, significantly reduced with...
Disrupted-In-Schizophrenia 1 (DISC1) is a candidate risk factor for schizophrenia, bipolar disorder and severe recurrent depression. Here, we demonstrate that DISC1 associates robustly with trafficking-protein-Kinesin-binding-1 which is, in turn, known to interact the outer mitochondrial membrane proteins Miro1/2, linking mitochondria kinesin motor microtubule-based subcellular trafficking. also Miro1 thus component of functional transport complexes. Consistent these observations, neuronal...
Major “storm tracks”, where migratory cyclones and anticyclones recurrently develop, are observed around midlatitude oceanic frontal zones with strong meridional gradient of sea‐surface temperature (SST). A set atmospheric general circulation model experiments is performed zonally uniform SST prescribed at the lower boundary. The latitudinal profile for each hemisphere characterized by a single front. latitude varied systematically from one experiment to another, while intensity kept...
Nuclear distribution factor E-homolog 1 (NDE1), Lissencephaly (LIS1), and NDE-like (NDEL1) together participate in essential neurodevelopmental processes, including neuronal precursor proliferation differentiation, migration, neurite outgrowth. NDE1/LIS1/NDEL1 interacts with Disrupted Schizophrenia (DISC1) the cAMP-hydrolyzing enzyme phosphodiesterase 4 (PDE4). DISC1, PDE4, NDE1, NDEL1 have each been implicated as genetic risk factors for major mental illness. Here, we demonstrate that DISC1...
Disrupted-In-Schizophrenia 1 (DISC1) was identified as a risk factor for psychiatric illness through its disruption by balanced chromosomal translocation, t(1;11)(q42.1;q14.3), that co-segregates with schizophrenia, bipolar disorder and depression. We previously reported the translocation reduces DISC1 expression, consistent haploinsufficiency disease model. Here we report that, in lymphoblastoid cell lines, additionally results production of abnormal transcripts due to fusion disrupted gene...
Abstract There is a growing demand for skillful prediction systems in the Arctic. Using Norwegian Climate Prediction Model that combines fully coupled Earth System and Ensemble Kalman filter, we present system performs both, weakly data assimilation (wCDA) when assimilating ocean hydrography (by updating alone) strongly sea ice concentration (SIC) jointly ocean). We assess seasonal skill of this version Model, first climate using assimilation, by performing retrospective predictions...
Tropical cyclones developing over the ocean threaten society when they approach land. A recent study has shown that global mean distance of tropical at their lifetime maximum intensity (LMI) to land decreased last 40 years. However, whether this trend is due warming or natural variability still needs be determined. This aims identify primary driver observed trend. We analyzed both atmosphere-only and coupled simulations following CMIP6 HighResMIP protocol with models from PRIMAVERA project....
The stratospheric dynamics and associated extremes, such as sudden warmings (SSWs) the formation of polar clouds (PSCs), exhibit a pronounced interhemispheric asymmetry. SSWs are exceedingly rare in Antarctic, while extreme cooling conditions required for water-based PSCs (Type II) infrequent short-lived Arctic. To investigate drivers this asymmetry, we conducted series semi-idealized model experiments, progressing from aqua-planet configurations mimicking Southern Hemisphere (SH) to more...
The atmospheric jet stream governs the distribution and intensity of midlatitude weather systems climate variability. In Northern Hemisphere, meridional migrations are directly linked to frequency magnitude extreme events. While previous studies have established that fluctuations modulated by spatio-temporal variations in diabatic heating, relationship between low-frequency modes oceanic variability remains unclear. Here we propose a hypothesis Annular Mode (NAM) Pacific Decadal Variability...
Disrupted in schizophrenia 1 (DISC1) is a leading candidate susceptibility gene for schizophrenia, bipolar disorder and recurrent major depression, which has been implicated other psychiatric illnesses of neurodevelopmental origin, including autism. DISC1 was initially identified at the breakpoint balanced chromosomal translocation, t(1;11) (q42.1;14.3), family with high incidence illness. Carriers translocation show 50% reduction protein levels, suggesting altered expression as pathogenic...
Abstract While the climatological-mean sensible and latent heat fluxes are remarkably well described using fields in bulk flux formulas, this study shows that a significant fraction of wind speed midlatitudes is associated with variations on synoptic time scales. Hence, prevailing direction most intense air–sea exchange can differ from mean direction. To pinpoint these striking differences between climatological viewpoint, presents global climatology surface during exchanges calculated for...
The individual impact of North Atlantic and Pacific Ocean Western Boundary Currents (OWBCs) on the tropospheric circulation has recently been studied in depth. However, their simultaneous role shaping hemisphere-scale wintertime troposphere/stratosphere-coupled its variability have not considered. Through semi-idealized Atmospheric General-Circulation-Model experiments, we show that OWBCs jointly maintain shape hemispheric leading mode Northern Annular Mode (NAM). energize baroclinic waves...
Mitochondria are essential for neuronal function, providing the energy required to power neurotransmission, and fulfilling many important additional roles. In neurons, mitochondria must be efficiently transported sites, including synapses, where their functions required. Neurons, with highly elongated morphology, consequently extremely sensitive defective mitochondrial trafficking which can lead ill-health/death. We recently demonstrated that DISC1 associates complexes it core kinesin dynein...
Coordinated numerical ensemble experiments with six different state-of-the-art atmosphere models have been used in order to evaluate the respective impact of observed Arctic sea ice and surface temperature (SST) variations on air mid high latitude land areas. Two sets designed; first set (EXP1), daily concentration SST are as lower boundary forcing over 1982–2014 while second (EXP2) replaced by climatology. The winter 2 m (T2m) relatively well reproduced a number areas EXP1, best agreement...
Abstract A midlatitude oceanic frontal zone is a confluent region of warm and cool ocean currents, characterized by strong meridional gradient in both sea surface temperature (SST) air (SAT). While recent observational modeling studies indicate potential impacts fronts on the extratropical climatological circulation, including storm tracks eddy-driven westerlies, their atmospheric-dominant low-frequency variability (i.e., annular mode) still remain to be understood. This study explores...
Abstract The late twentieth century was marked by a significant summertime trend in the Southern Annular Mode (SAM), dominant mode of tropospheric variability extratropical Hemisphere (SH). This with poleward shifting westerlies attributed to downward propagation stratospheric changes induced ozone depletion. However, role ocean setting SAM response depletion and its dynamical forcing remains unclear. Here we show, using idealized experiments state‐of‐the‐art atmospheric model analysis...
Abstract Atmospheric blocking is a crucial driver of extreme weather events, but its climatological frequency largely underestimated in state-of-the-art climate models, especially around the North Atlantic. While air-sea interaction along Atlantic oceanic frontal region known to influence activity, remote effects from Pacific have been less studied. Here we use semi-idealised experiments with an atmospheric general circulation model demonstrate that mid-latitude front for activity. The...
Disrupted in schizophrenia 1 (DISC1) is a risk factor for spectrum of neuropsychiatric illnesses including schizophrenia, bipolar disorder, and major depressive disorder. Here we use two missense Disc1 mouse mutants, described previously with distinct behavioural phenotypes, to demonstrate that variation exerts differing effects on the formation newly generated neurons adult hippocampus. mice carrying homozygous Q31L mutation, displaying depressive-like have fewer proliferating cells while...
Disrupted-In-Schizophrenia 1 (DISC1), a strong genetic candidate for psychiatric illness, encodes multicompartmentalized molecular scaffold that regulates interacting proteins with key roles in neurodevelopment and plasticity. Missense DISC1 variants are associated the risk of mental illness brain abnormalities healthy carriers, but underlying mechanisms unclear. We examined effect rare common amino acid substitutions on subcellular targeting. report both putatively causal variant 37W 607F...