A5078073911- Synthesis of β-Lactam Compounds
- Synthesis and Catalytic Reactions
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and Biological Evaluation
- Chemical synthesis and pharmacological studies
- Asymmetric Synthesis and Catalysis
- Nanomaterials for catalytic reactions
- Organoselenium and organotellurium chemistry
- Synthesis and Biological Activity
- Multicomponent Synthesis of Heterocycles
- Chemical Synthesis and Reactions
- Organic Chemistry Cycloaddition Reactions
- Solid-state spectroscopy and crystallography
- Peptidase Inhibition and Analysis
- Advanced biosensing and bioanalysis techniques
- Pneumocystis jirovecii pneumonia detection and treatment
- Asymmetric Hydrogenation and Catalysis
- Chemical Synthesis and Analysis
- Histone Deacetylase Inhibitors Research
- Metal complexes synthesis and properties
- Organometallic Compounds Synthesis and Characterization
- Selenium in Biological Systems
- Phenothiazines and Benzothiazines Synthesis and Activities
- Sulfur-Based Synthesis Techniques
Panjab University
2016-2025
Centre of Advanced Studies
2019-2024
Chandigarh University
2018-2019
Pennsylvania State University
1974-1990
Marshall Space Flight Center
1974
Schiff bases are most the widely used class of molecules in organic as well inorganic chemistry and known for fabricating stable metal complexes. their complexes utilized pharmaceutically medicinally important scaffolds because versatile biological profile. So herein, this review, we summarized recently developed biologically active with V, Fe, Co, Ni, Cu, Zn, Zr, Rh, Pd, Cd, Sn, Ir, Pt, Pb metals. The anti-bacterial, anti-fungal, anti-viral, anti-microbial, anti-cancer, corrosion inhibiting...
Green catalytic synthesis of benzimidazoles using Cu metallovesicles as nanoreactors.
A highly efficient, operationally simple, green catalytic approach using Pd–Ni alloy nanoparticles for Mizoroki Heck coupling.
ABSTRACT This article, describe the synthesis of 4‐ethynylaniline derived 1,2,3‐bis‐triazole ( 3 ) via Cu(I) catalyzed click reaction and various spectroscopic methods such as FT‐IR, TGA, 1 H 13 C NMR, mass spectrometry are used for characterization. The probe exhibits high sensitivity selectivity to Sn (II) in UV–visible spectroscopy, with a limit detection 27 μM association constant 8.32 MM −1 , respectively. synthetic sensor practical application was further explored by detecting real...
Abstract Colorectal cancer (CRC) is a multistep disorder resulting from genetic and epigenetic genome changes. It the third most common malignancy in developed nations accounting for roughly 600,000 deaths annually. Persistent gut inflammation, as observed inflammatory bowel disease (IBD), key risk factor CRC development. From an viewpoint, pharmacological inhibition of HDACs using HDAC inhibitors such SAHA has emerged suitable anticancer strategy recent past. However, clinical success these...
trans-1-(4′-Methoxyphenyl)-3-methoxy-4-phenyl 3-methoxyazetidin-2-one (or 3-methoxyazetidin-2-one) is one of the important β-lactam derivatives with an ample range bacterial activities yet few restrictions. To enhance competency chosen 3-methoxyazetidin-2-one, microfibrils composed copper oxide (CuO) and filter scraps cigarette butts (CB) were in current work for developing a potential release formulation. The preparation CuO-CB required simple reflux technique subsequent calcination...
Abstract Herein, trans‐ and cis‐ azetidin‐2‐ones 3–6 were strategically synthesized, capitalizing on the bioactivity of indole pharmacophore, followed by a comprehensive characterization using diverse array spectroscopic techniques. The sixteen examined for antimicrobial activities against both Gram‐negative ( P. aeruginosa , E. coli A. baumannii ) Gram‐positive bacteria (S . aureus, faecium, B. cereus ), as well C. albicans tropicalis fungal strains. highly potent compounds 5 6 b d...
Abstract An operationally simple and efficient approach for the synthesis of novel spiro‐β‐lactams is described. The key reaction a halogen‐mediated intrasulfenyl cyclization cis ‐3‐benzylthio‐3‐(prop‐2‐ynyloxy/‐enyloxy)‐β‐lactam procured through Lewis acid‐mediated C‐3‐alkylation trans ‐3‐benzylthio‐3‐chloro‐β‐lactam carbocation equivalent. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
Herein, a novel synthetic methodology was devised to synthesize cis -3-aroyl-thiourea/urea-β-lactams by reacting aroyl isothiocyanates/isoselenocyanates with -3-amino-β-lactams.
Diverse chiral trans and cis-3-chloro/oxo/thio-4-styryl-β-lactams were efficiently synthesized using 3′-phenylallylidene-[(R)-1′-phenylethyl] amine substituted ethanoic acids. Moore ketenes derived from chloro/phenythio/benzylthio acids (Cl/PhS/BzS) affords both trans- cis β-lactams, with a preference for trans-stereochemistry. However, Bose-Evans obtained 2-methoxy/phenoxyethanoic (MeO/PhO), led to the exclusive formation of cis-diastereomers only. Further, individual diastereomers...