A5084496241- Evolution and Genetic Dynamics
- Evolutionary Game Theory and Cooperation
- Bacteriophages and microbial interactions
- Plant and animal studies
- Gut microbiota and health
- Microbial Community Ecology and Physiology
- Genomics and Phylogenetic Studies
- Plant Virus Research Studies
- Mycorrhizal Fungi and Plant Interactions
- Insect and Arachnid Ecology and Behavior
- Insect symbiosis and bacterial influences
- Aquaculture disease management and microbiota
- Bacterial Genetics and Biotechnology
- Genetics, Aging, and Longevity in Model Organisms
- Pharmacogenetics and Drug Metabolism
- Biomedical and Engineering Education
- Yersinia bacterium, plague, ectoparasites research
- Genetics, Bioinformatics, and Biomedical Research
- Ecosystem dynamics and resilience
- Empathy and Medical Education
- HIV Research and Treatment
- Machine Learning in Bioinformatics
- SARS-CoV-2 detection and testing
- Probiotics and Fermented Foods
- Listeria monocytogenes in Food Safety
Maladies Infectieuses et Vecteurs: Écologie, Génétique, Évolution et Contrôle
2021-2024
Centre National de la Recherche Scientifique
2015-2024
Université de Montpellier
2013-2024
Institut de Recherche pour le Développement
2021-2024
ETH Zurich
2018-2023
Institut des Sciences de l'Evolution de Montpellier
2013-2018
Université Paul-Valéry Montpellier
2017
École Pratique des Hautes Études
2017
Centre d'Écologie Fonctionnelle et Évolutive
2017
Institut Agro Rennes-Angers
2012-2016
The evolution of antibiotic resistance in bacteria is a global concern and the use bacteriophages alone or combined therapies attracting increasing attention as an alternative. Evolutionary theory predicts that probability bacterial to both phages antibiotics will be lower than either separately, due for example fitness costs trade-offs between phage mechanisms growth. In this study, we assess population impacts individual treatments bacteriophage streptomycin on nosocomial pathogen...
Abstract Generalist bacterial predators are likely to strongly shape many important ecological and evolutionary features of microbial communities, for example by altering the character pace molecular evolution, but investigations such effects scarce. Here we report how predator-prey interactions alter evolution fitness, genomes phenotypic diversity in coevolving communities composed Myxococcus xanthus as predator Escherichia coli prey, relative single-species controls. We show evidence...
Ecological variation influences the character of many biotic interactions, but examples predator–prey reversal mediated by abiotic context are few. We show that temperature at which prey grow before interacting with a bacterial predator can determine very direction predation, reversing and identities. While Pseudomonas fluorescens reared 32°C was extensively killed generalist Myxococcus xanthus , P . 22°C became predator, slaughtering M to extinction growing on its remains. Beyond diffusible...
Abstract Antibiotic resistance is becoming increasingly problematic for the treatment of infectious disease in both humans and livestock. The bacterium P seudomonas aeruginosa often found to be resistant multiple antibiotics causes high patient mortality hospitals. Bacteriophages represent a potential option combat pathogenic bacteria through their application phage therapy. Here, we capitalize on previous studies showing how evolution may increase infection capacity relative ancestral...
With escalating resistance to antibiotics, there is an urgent need develop alternative therapies against bacterial pathogens and pests. One of the most promising employment bacteriophages (phages), which may be highly specific evolve counter antiphage resistance. Despite increased understanding how phages interact with bacteria, we know very little about their interactions modified in antibiotic environments and, reciprocally, phage affect evolution We experimentally evaluated impacts single...
The frequency and the geographical extent of symbiotic associations between ants fungi order Chaetothyriales have been highlighted only recently. Using a phylogenetic approach based on seven molecular markers, we showed that ant-associated are scattered through phylogeny this order. There was no clustering according to origin or taxonomy ant host. However, strains tended be clustered type association with ants: from ant-made carton plant cavities occupied by ('domatia') rarely together....
While predators and parasites are known for their effects on bacterial population biology, impact the dynamics of social evolution remains largely unclear. Siderophores iron-chelating molecules that key to survival certain species in iron-limited environments, but production can be subject cheating by non-producing genotypes. In a selection experiment conducted over approximately 20 generations involving 140 populations pathogenic bacterium Pseudomonas aeruginosa PAO1, we assessed lytic...
Phages, the viruses of bacteria, have been proposed as antibacterial agents to complement or replace antibiotics due growing problem resistance. In nature and in clinic, are ubiquitous may affect phages indirectly via impacts on bacterial hosts. Even if synergistic association has shown several studies, focus is often bacteria with little known about impact phages. Evolutionary studies demonstrated that time scale an important factor understanding consequences antimicrobial strategies, but...
Significance The evolution of cooperation is a central issue in biology and the social sciences. Study model systems microbes has focused on how “cooperators” “cheats” interact but rarely accounts for surrounding environment. We demonstrate environmental stress form antibiotics alters public goods bacterium. Antibiotics accentuate costs to cooperators, resulting their rapid demise relative cheats. In more applied vein, antibiotic resistance was maximal presence both producers cheats,...
Stress is thought to increase mutation rate and thus accelerate evolution. In the context of antibiotic resistance, sub-inhibitory treatments could then lead enhanced evolvability, thereby fuelling adaptation pathogens. Combining wet-lab experiments, stochastic simulations a meta-analysis literature, we found that in rates triggered by often cancelled out reduced population size, resulting no overall genetic diversity. A careful analysis effect ecological factors on diversity showed...
Abstract How does microbiota research impact our understanding of biological individuality? We summarize the interdisciplinary summer school on “Microbiota, symbiosis and individuality: conceptual philosophical issues” (July 2019), which was supported by a European Research Council starting grant project “Immunity, DEvelopment, Microbiota” (IDEM). The centered around group work four facets research: holobionts, individuality, causation, human health. discussion cutting-edge empirical...
Theory and empirical studies in metazoans predict that apex predators should shape the behavior ecology of mesopredators prey at lower trophic levels. Despite ecological importance microbial communities, few predatory microbes examine such behavioral res-ponses multiplicity interactions. Here, we sought to assemble a three-level food chain test for interactions between nematode Caenorhabditis elegans social bacterium Myxococcus xanthus when cultured together with two basal bacteria both can...
Evolutionary diversification can occur in allopatry or sympatry, be driven by selection unselected, and phenotypically manifested immediately remain latent until a newly encountered environment. Diversification of host–parasite interactions is frequently studied the context intrinsically selective coevolution, but potential for interaction phenotypes to diversify latently during parasite-blind host evolution rarely considered. Here, we use social bacterium experimentally adapted several...
Abstract Background Social defectors may meet diverse cooperators. Genotype-by-genotype interactions constrain the ranges of cooperators upon which particular can cheat, limiting cheater spread. Upon starvation, soil bacterium Myxococcus xanthus cooperatively develops into spore-bearing fruiting bodies, using a complex regulatory network and several intercellular signals. Some strains (cheaters) are unable to sporulate effectively in pure culture due mutations that reduce signal production...
Social defectors may meet diverse cooperators. Genotype-by-genotype interactions constrain the ranges of cooperators upon which particular can cheat, limiting cheater spread. The bacterium Myxococcus xanthus undergoes cooperative multicellular development, but some developmental cheat on during this process. In study, between a disrupted at signaling gene csgA and allopatrically diversified reveal very small cheating range. Expectedly, failed to all natural-isolate owing non-cheater-specific...
Abstract Phage host-range expansion is predicted to be at the cost of lower mean fitness. We aimed following adaptive walks a virulent phage ( Tequintavirus ) evolving in spatially variable environment composed four susceptible and resistant strains Salmonella enterica pv Tennessee, sequence types ST5018 ST319 respectively). evolved single ancestor through serial passages on non-coevolving bacterial Appelmans’ protocol obtained several populations with expanded increased virulence....
Ecological variation influences the character of many biotic interactions, but examples predator-prey reversal mediated by abiotic context are few. We show that temperature at which prey grow before interacting with a predatory bacterial species can determine very direction predation, reversing identities predator and prey. When lawns Pseudomonas fluorescens were reared 32 °C release generalist Myxococcus xanthus, M. xanthus extensively killed P. fluorescens. However, when was released onto...
1 Abstract Stress is thought to increase mutation rate and thus accelerate evolution. In the context of antibiotic resistance, sub-inhibitory treatments could then lead enhanced evolvability, thereby fueling adaptation pathogens. Conducting a meta-analysis published experimental data as well our own experiments, we found that in rates triggered by often canceled out reduced population size, resulting no overall genetic diversity. A careful analysis effect ecological factors on diversity...
Evolutionary diversification can occur in allopatry or sympatry, be unselected driven by selection, and phenotypically manifested immediately remain latent until later manifestation a newly encountered environment. Diversification of host-parasite interactions is frequently studied the context intrinsically selective coevolution, but potential for interaction phenotypes to diversify latently during parasite-blind evolution rarely considered. Here we use social bacterium experimentally...
In 2020 the world was hit by COVID-19 pandemic putting entire governments and civil societies in crisis mode. Around globe unprecedented shortages of equipment qualified personnel were reported hospitals diagnostic laboratories. When a is global, supply chains are strained worldwide external help may not be readily available. Switzerland, as part efforts Swiss National Science Task Force, we developed tailor-made web-based tool where needs offers for critical laboratory expertise can brought...
The most recent version of this paper has been removed owing to copyright violation. Earlier versions the remain available.
Abstract Theory and empirical studies in metazoans predict that apex predators should shape the behavior ecology of mesopredators prey at lower trophic levels. Despite ecological importance microbial communities, few predatory microbes examine such behavioral responses multiplicity interactions. Here, we sought to assemble a three-level food chain test for interactions between nematode Caenorhabditis elegans social bacterium Myxococcus xanthus when cultured together with two basal bacteria...