A5037925075- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Endometriosis Research and Treatment
- Circular RNAs in diseases
- Neonatal Respiratory Health Research
- Dermatology and Skin Diseases
- Birth, Development, and Health
- Preterm Birth and Chorioamnionitis
- Land Use and Ecosystem Services
- COVID-19 Impact on Reproduction
- Pregnancy and Medication Impact
- Pregnancy-related medical research
- Cardiovascular Issues in Pregnancy
- Maternal and fetal healthcare
- IL-33, ST2, and ILC Pathways
- Cancer-related molecular mechanisms research
- Bat Biology and Ecology Studies
- Tissue Engineering and Regenerative Medicine
- Human Mobility and Location-Based Analysis
- Menstrual Health and Disorders
- Viral Infections and Vectors
- Renal and related cancers
- Toxoplasma gondii Research Studies
Jena University Hospital
2018-2025
Friedrich Schiller University Jena
2020-2022
Instituto Politécnico Nacional
2015-2020
Tecnológico Nacional de México
2015
Extracellular vesicles (EVs), including small EVs (sEVs), are involved in neuroinflammation and neurodegenerative diseases, Alzheimer's disease, Parkinson's amyotrophic lateral sclerosis. Yet, increased can also be detected the aging brain, it is associated with glial activation. Changes EV concentration reported tissues senescence cells, suggesting a role of process aging. Here, we investigated effect peripheral sEVs from aged animals on neuroinflammation, specifically were isolated blood...
Placenta accreta spectrum (PAS) is one of the major causes maternal morbidity and mortality worldwide with increasing incidence. PAS refers to a group pathological conditions ranging from abnormal attachment placenta uterus wall its perforation and, in extreme cases, invasion into surrounding organs. Among them, characterized by direct adhesion villi myometrium without remains most common diagnosis PAS. Here, we identify potential regulatory miRNA target networks contributing development....
Background Pregnant women represent a vulnerable group in pharmaceutical research due to limited knowledge about drug metabolism and safety of commonly used corticosteroids like prednisone ethical practical constraints. Current preclinical models, including animal studies, fail accurately replicate human pregnancy conditions, resulting gaps pharmacokinetics predictions. To address this issue, we three-organ microphysiological system (MPS) combined with digital twin framework, predict fetal...
Members of the placenta-specific miRNA cluster C19MC, including miR-519d, are secreted by fetal trophoblast cells within extracellular vesicles (EVs). Trophoblast-derived EVs can be internalized autologous and surrounding maternal immune cells, resulting in coordination cellular responses. The study functions targets placental miRNAs donor recipient may contribute to understanding tolerance essential pregnancy. Here, we report that miR-519d-3p levels correlate positively with cell...
Epithelial membrane proteins (EMP1-3) are involved in epithelial differentiation and carcinogenesis. Dysregulated expression of EMP2 was observed various cancers, but its role human lung cancer is not yet clarified. In this study, we analyzed the EMP1-3 investigated biological function non-small cell (NSCLC). The results showed that lower EMP1 significantly correlated with tumor size primary tumors (p = 0.004). Overexpression suppressed growth, migration, invasion, resulting a G1 cycle...
Do microRNAs (miRNAs) play a role in regulating endoplasmic reticulum stress (ERS) and unfolded protein response (UPR) decidualized cells endometrium associated with reproductive failures?Endometrial stromal cell line St-T1b was vitro 8-Br-cAMP over 5 days, or treated the ERS inducer thapsigargin. Expression of sensors, UPR markers potential miRNA regulators analysed by quantitative PCR. Endometrial biopsies from patients recurrent pregnancy loss (RPL) implantation failure (RIF) were...
IL-36 cytokines (the agonists IL-36α, IL-36β, IL-36γ, and the antagonist IL-36Ra) are expressed in mouse uterus associated with maternal immune response during pregnancy. Here, we characterize expression of members human primary trophoblast cells (PTC) trophoblastic cell lines (HTR-8/SVneo JEG-3) upon treatment bacterial viral components. Effects recombinant on migration capacity cells, their ability to interact endothelial induction angiogenic factors miRNAs (angiomiRNAs) were examined....
The IL-36 subfamily is a recently described group of cytokines with pro-inflammatory behavior, comprising three agonists (α, β, and γ), its receptor (R), one antagonist (Ra). expression function members in the estrous cycle healthy infected pregnancy has not been described. We evaluated mRNA protein family during cycle, implantation, fetal development, post-labor periods model allogenic mice. also explored ability Listeria monocytogenes to modulate pregnancy. Expression showed different but...
During pregnancy, NF-κB plays an important role for embryo implantation and the onset of labor. Regulated IL-6 production, under transcriptional control NF-κB, is essential a successful pregnancy outcome atypical regulator IκBNS involved in this process. Previously, we showed that negatively regulates uterine tissues during mouse estrous cycle. In work, analyzed if expression pregnant mice physiological or L. monocytogenes-infected conditions would remain as observed healthy was highly...