A5080989917- Cancer Immunotherapy and Biomarkers
- Gut microbiota and health
- Comparative Literary Analysis and Criticism
- Ethics and bioethics in healthcare
- Immune Cell Function and Interaction
- Cancer Treatment and Pharmacology
- Bacterial Identification and Susceptibility Testing
- Olfactory and Sensory Function Studies
- Empathy and Medical Education
- Pancreatitis Pathology and Treatment
- Latin American Literature Analysis
- Neutropenia and Cancer Infections
- Health and Medical Education
- Colorectal Cancer Treatments and Studies
- Infrared Thermography in Medicine
- Healthcare cost, quality, practices
- Cancer Genomics and Diagnostics
- Developmental and Educational Neuropsychology
- Renal and related cancers
- Venous Thromboembolism Diagnosis and Management
- Indoor Air Quality and Microbial Exposure
- Microbial Natural Products and Biosynthesis
- Tissue Engineering and Regenerative Medicine
- Clinical Laboratory Practices and Quality Control
- Acupuncture Treatment Research Studies
Instituto de Carboquímica
2019-2025
Instituto de Investigación Sanitaria Aragón
2021-2024
Hospital Universitari Sant Joan D'Alacant
2016-2024
Aston University
2020
Institute for Social Security and Services for State Workers
1969-2018
(1) Despite the effectiveness of immune checkpoint inhibitors (ICIs) in lung cancer, there is a lack knowledge about predictive biomarkers. The objective our study to analyze different subsets T-lymphocytes and natural killer (NK) cells as biomarkers cohort patients with nonsmall cell cancer (NSCLC) treated ICI. (2) This an observational, prospective 55 NSCLC A total 43 T NK are analyzed peripheral blood, including main markers exhaustion, differentiation, memory, activation, inhibition. (3)...
During respiratory infections, host-pathogen interaction alters metabolism, leading to changes in the composition of expired volatile organic compounds (VOCs) and soluble immunomodulators. This study aims identify VOC blood biomarker signatures develop machine learning-based prognostic models capable distinguishing infections with similar symptoms. Twenty-one VOCs fifteen serum biomarkers were quantified samples from 86 COVID-19 patients, 75 patients non-COVID-19 72 healthy donors. The...
Immune checkpoint inhibitors have been proposed as the standard treatment for different stages of non-small-cell lung cancer in multiple indications. Not all patients benefit from these treatments, however, and certain develop immune-related adverse events. Although search predictors response to drugs is a major field research, issues yet be resolved. It has postulated that microbiota could play relevant role conditioning treatments; human factor intestinal permeability also needs considered...
Multidrug-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) is one of the major causes hospital-acquired and community infections pose a challenge to human health care system. Therefore, it important find new drugs that show activity against these bacteria, both in monotherapy combination with other antimicrobial drugs. Gliotoxin (GT) mycotoxin produced by Aspergillus fumigatus fungi genus. Some evidence suggests GT shows S. vitro, albeit its efficacy...
Background: Recent research has evaluated psychological and biological characteristics associated with pain in survivors of breast cancer (BC). Few studies consider their relationship inflammatory activity. Voluntary facial expressions modify the autonomic activity this may be useful hospital environment for clinical biopsychosocial assessment pain. Methods: This compared a BC group under integral treatment (Oncology, Psychology, Nutrition) control to assess intensity pain, behavioral...
Aims:Recent in vitro findings suggest that the serine protease Granzyme K (GzmK) may act as a proinflammatory mediator.However, its role sepsis is unknown.Here we aim to understand of GzmK mouse model bacterial and compare it biological relevance A (GzmA).Methods: Sepsis was induced WT, GzmA -/-and -/-mice by an intraperitoneal injection 2x10 8 CFU from E. coli.Mouse survival monitored during 5 days.Levels IL-1α, IL-1β, TNFα IL-6 plasma were measured load blood, liver spleen...
The aim of this work is twofold. Firstly, to study the temporal evolution in number laboratory requests from primary care without clinical indication, and analyse such before after implementation an automated requesting procedure. Secondly, investigate what are most frequent indications that prompted testing.This a retrospective observational conducted January 2009 December 2015. We counted question, calculated per total listed indications.The tests with blank indication was significantly...
Gliotoxin (GT), a secondary metabolite produced by Aspergillus molds, has been proposed as potential anti-tumor agent. Here we have developed nanoparticle approach to enhance delivery of GT in tumor cells and establish basis for its use therapeutical drug. bound magnetic nanoparticles (MNPs) retained high activity, correlating with efficient intracellular delivery, which was increased the presence glucose. Our results show that attachment MNPs covalent bonding enhances without affecting...
Gliotoxin is a fungal secondary metabolite with impact on health and agriculture since it might act as virulence factor contaminate human animal food. Homologous gliotoxin (GT) gene clusters are spread across number of species although if they produce GT or other related epipolythiodioxopiperazines (ETPs) remains obscure. Using bioinformatic tools, we have identified homologous gli similar to the A. fumigatus cluster in several species. In silico study led vitro confirmation...
The biopsychosocial evaluation of a 61-year-old male patient with diagnosis osteoarthrosis for 8 years is presented. A salivary sample the inflammatory response interleukin 6 (IL-6), its heart rate variability, and psychological measures associated pain were collected. An A-B-A design was used to assess their thermal from relaxation training after stress test. corrugator, zygomatic nose tip muscles evaluated. results indicate high concentration IL-6, level behavioral cognitive interference;...
<title>Abstract</title> Lung cancer is a leading cause of morbidity and mortality globally, with its high rate attributed mainly to non-small cell lung (NSCLC). Although immunotherapy immune checkpoint inhibitors (ICI) has revolutionized treatment, patient response highly variable lacking predictive markers. We conducted prospective study on 55 patients NSCLC undergoing ICI therapy identify markers both immune-related adverse events (IrAEs) in the airway microbiota. also analyzed clinical...
<title>Abstract</title> The development of immune checkpoints inhibitors (ICIs) has changed the therapeutic paradigm lung cancer (LC), becoming standard treatment for previously untreated advanced non-small cell (NSCLC) without actionable mutations. It allowed achievement durable responses and resulted in significant survival benefits. However, not all patients respond, hence molecular biomarkers are needed to help us predict which will respond. With this objective, a prospective...
The development of immune checkpoint inhibitors (ICIs) has changed the therapeutic paradigm lung cancer (LC), becoming standard treatment for previously untreated advanced non-small cell (NSCLC) without actionable mutations. It allowed achievement durable responses and resulted in significant survival benefits. However, not all patients respond; hence, molecular biomarkers are needed to help us predict which will respond. With this objective, a prospective observational study was designed,...
Granzymes (Gzms), a family of serine proteases, expressed by immune and nonimmune cells, present perforin-dependent independent intracellular extracellular functions. When released in the space, GzmA, with trypsin-like activity, is involved pathophysiology different inflammatory diseases. However, there are no validated specific systems to detect active forms making it difficult assess its biological relevance potential use as biomarker. Here, we have developed fluorescence-energy...
En este articulo se propone una aproximacion al conjunto de la obra poetica Marosa di Giorgio (Salto, 1932-Montevideo 2004) a traves del motivo voz, entendido desde perspectivas diversas que, imbricadas entre si, permiten sondear algunas las lineas fundamentales un proyecto escritura que constituye intensa experiencia en el marco letras uruguayas e hispanicas contemporaneas. A partir estas generales ira rastreando tratamiento voces presentes los poemas: voz desdoblada ante quiebre temporal...