A5035656661- Inflammatory mediators and NSAID effects
- Head and Neck Cancer Studies
- Chemotherapy-induced organ toxicity mitigation
- Cancer, Lipids, and Metabolism
- Paraoxonase enzyme and polymorphisms
- Head and Neck Surgical Oncology
- Essential Oils and Antimicrobial Activity
- Oral and Maxillofacial Pathology
- Phytochemical and Pharmacological Studies
- Nanoparticles: synthesis and applications
- Biomarkers in Disease Mechanisms
- Cancer-related molecular mechanisms research
- AI in cancer detection
- Estrogen and related hormone effects
- Click Chemistry and Applications
- Cancer Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Flavonoids in Medical Research
- Radiomics and Machine Learning in Medical Imaging
- Synthesis and biological activity
- RNA modifications and cancer
- Garlic and Onion Studies
- Lung Cancer Research Studies
- Colorectal Cancer Screening and Detection
- Phytochemicals and Medicinal Plants
Manipal Academy of Higher Education
2021-2025
Kasturba Medical College, Manipal
2021-2025
The PTGS2 gene codes for the cyclooxygenase-2 (COX-2) enzyme that catalyzes committed step in prostaglandin (PG) synthesis. Various in-vivo and in-vitro data suggest E2 mediates as a signaling molecule activating VEGF pathway (VSP), forming an association between COX-2 VSP. Several chemotherapy regimens increasingly rely on preventing synthesis of PGs. targeted metronomic agents, which suppress enzymes, have major role suppressing oral cancer cascade. Hence, this study was designed to...
Abstract Background PTGS2 encodes cyclooxygenase‐2 (COX‐2), which catalyses the committed step in prostaglandin synthesis. Various vivo and vitro data suggest that COX‐2 mediates VEGF signalling pathway. In silico analysis performed TCGA, PanCancer Atlas for head neck cancers, demonstrated significant expression co‐expression of genes regulate signalling. This study was designed to elucidate pattern regulating patients with locally advanced oral squamous cell carcinoma (OSCC). Methodology...
Abstract Locally advanced oral squamous cell carcinoma poses a significant challenge in oncology due to its rising incidence and mortality rates. Despite therapeutic progress, understanding molecular intricacies is essential. This study explored the role of PON2 , multifunctional enzyme implicated antiapoptotic mechanisms. Aberrant expression cancers raises questions regarding involvement evading programmed death treatment resistance. Patients with locally disease were enrolled, analyses...
, also known as URCL4, has been reported to have higher expression and be associated with poor prognosis in lung adenocarcinoma patients, its role regulation of the EGFR/AKT/mTORC1 pathway recently elucidated. In current study, we used publicly available data experimental validation
Abstract Several in vitro investigations of the therapeutic characteristics B. bulbocastanum have shown that it has cytotoxic, antifungal, and antibacterial effects. It also exhibits antioxidant anticancer When ethyl acetate fraction was examined for its phytochemical composition, found to be rich phenolic compounds had significant cytotoxic effects on PC-3 cell lines. The prostate length-to-weight ratio significantly higher vivo fraction-treated group. Compared disease control group,...
In this paper, I present a method for improving polyp diagnosis during endoscopy using image segmentation techniques. The involves technique precisely segmenting polyps from endoscopic images cutting-edge deep learning algorithms. convolutional neural network (DCNN) is trained hand-segmented dataset that includes range of sizes, shapes, and appearances. Using different validation dataset, the performance suggested assessed by contrasting outcomes automated with those manual annotations. When...
Over many centuries, traditional medicines have been used by countries throughout the world and reflect vital part of healthcare. The use medicine has gained popularity in last few decades expanded globally. Indian medicine, Ayurveda being most ancient yet promoting supporting extensive research therapies for various health needs. Bunium bulbocastanum, also known as kala jeera (black cumin), is a member Apiaceae family. Its fruit food several years, it can be consumed raw or cooked to add...
Resistance to antimicrobial agents has become an increasingly important and pressing global problem. Hence, new classes of drugs are urgently required and, in this regard, flavonoids represent a novel set leads. This study was done evaluate activity synthetic quercetin analogue alone combination with standard drug gentamicin on gram positive gram-negative bacteria. Quercetin synthesized fresh the laboratory used check by agar well diffusion method negative gram-positive The mean zone...
Abstract Purpose: The oral cavity Squamous Cell Carcinoma (OCSCC) involving infratemporal fossa (ITF) is considered as cT4b stage per AJCC 8th classification. treatment of these group patients challenging due to the difficulty in achieving negative resection margin status. In this study we have highlighted our surgical technique with oncological outcome enbloc primary cancer ITF. Methodology: This was a single centre retrospective which included only OCSCC extending into Our systematic “out...