In tuberculosis (TB) endemic areas, other pyogenic causes of spine involvement may be missed. The study aimed to describe TB and non-TB identify features that can help in differentiating them.A retrospective cohort was conducted screen the clinical records all admitted patients (Kasturba Hospital, Manipal) 2018-20 for a diagnosis spondylitis and/or sacroiliitis. features, radiological findings, laboratory parameters, treatment details, outcomes were compared among those diagnosed with...

<ns3:p>Background Blastoid mantle cell lymphoma (B-MCL) is a rare aggressive lymphoma. It characterized by blastoid morphology with high proliferation and inconsistent immunohistochemistry (IHC), making it diagnostic challenge for the pathologist. Methods This retrospective analytical cohort study. We reviewed biopsy confirmed cases of B-MCL diagnosed over period 10 years (January 2012 to December 2022). The clinical presentation, histopathological IHC findings, treatment received, survival...

Neuroblastoma is the most common solid malignant neoplasm in paediatric age group; accounting for 7% of all childhood malignancies, but neuroblastoma adult, a rare occurrence, finding mention aeons medical literature with an overall incidence 1 10 million adults/year. We report case 24-year-old male patient presenting complaints progressive abdominal distention 2 months duration. Multiple Detector Computed Tomography (MD-CT) abdomen revealed huge enhancing mass retroperitoneum abutting left...

Patients with melioidosis can present a combination of fever, respiratory distress and focal involvement. Focal involvement bone joint is, however, rare in patients melioidosis. This study aimed to characterize osteoarticular melioidosis.This was retrospective review records all adult diagnosed culture-positive over three years. The clinical, laboratory treatment details were recorded predefined case-record form analyzed.Of the 11 melioidosis, 55% (n=6) had concurrent pulmonary classified as...

, also known as URCL4, has been reported to have higher expression and be associated with poor prognosis in lung adenocarcinoma patients, its role regulation of the EGFR/AKT/mTORC1 pathway recently elucidated. In current study, we used publicly available data experimental validation

Sweet’s Syndrome (SS) is an inflammatory skin condition characterised by sudden onset of fever, painful lesions and neutrophilic infiltration affected tissues. The systemic association SS include infections, drugs, malignancy autoimmune disorders. diagnosis requires prompt clinical suspicion followed histopathological confirmation. We describe a case 6-year-old boy with relapsed acute myeloid leukaemia (AML) presenting the fever diffuse erythematous papules over face, neck, trunk, arms legs....

Abstract Splenic abscess is a relatively uncommon condition, especially in pediatric malignancies. The diagnosis of splenic clinical challenge due to low incidence. condition fatal if not diagnosed on time. We are reporting two cases with underlying immune suppression secondary malignancy and multidrug-resistant sepsis abscesses as the focus. Both children had life-threatening required total splenectomy life-saving measure. Postsplenectomy course was uneventful improvement, chemotherapy...

Cutaneous invasive fungal infections are a highly feared complication of cancer chemotherapy in children. The increased risk for these is often attributed to the profound immunosuppression and neutropenia resulting from intensive chemotherapy. Common pathogens include Zygomycetes, Aspergillus, Candida species, each showing wide array clinical manifestations. We describe an outbreak four cases cutaneous children undergoing induction hematological malignancies pediatric hematology oncology...

Abstract Several in vitro investigations of the therapeutic characteristics B. bulbocastanum have shown that it has cytotoxic, antifungal, and antibacterial effects. It also exhibits antioxidant anticancer When ethyl acetate fraction was examined for its phytochemical composition, found to be rich phenolic compounds had significant cytotoxic effects on PC-3 cell lines. The prostate length-to-weight ratio significantly higher vivo fraction-treated group. Compared disease control group,...

<ns3:p>Background Blastoid mantle cell lymphoma (B-MCL) is a rare aggressive lymphoma. It characterized by blastoid morphology with high proliferation and inconsistent immunohistochemistry (IHC), making it diagnostic challenge for the pathologist. Methods This retrospective analytical cohort study. We reviewed biopsy confirmed cases of B-MCL diagnosed over period 10 years (January 2012 to December 2022). The clinical presentation, histopathological IHC findings, treatment received, survival...

Struma ovarii is a specialized variant of ovarian teratoma represented by predominance (>50%) thyroid tissue, and constitutes about 2.7% all newly diagnosed teratomas. The histomorphological spectrum the constituent tissue can range from normal banal follicles to adenoma like lesion thyroid-type carcinomas. Malignancy arising in struma very rare with most reported malignancies being usual papillary carcinoma or follicular carcinoma. Poorly differentiated (PDTC) extremely only 9 cases modern...

Introduction: We started this study with a research question that whether prolonged APTT, PT and decreased platelet counts have any correlation the patients having HIV, as compared to normal healthy controls also do these changes go hand in level of CD4 count thus reflecting disease progression. look for an answer that, can coagulation parameters be included routine testing care HIV patients? Does treatment effect on parameters? Aims Objectives: 1) To evaluate PT, compare them controls. 2)...

Renal infiltration by leukemia causing massive bilateral nephromegaly is an extremely rare presentation of T-cell acute lymphoblastic leukemia(T-ALL).18-month-old female toddler presented with fever and progressive abdominal distension 4-6 weeks duration. Imaging revealed massively enlarged kidneys normal excretion. Peripheral blood counts smear examination was unremarkable immunophenotypic evaluation marrow consistent T-ALL. Chest imaging unremarkable. She started on modified Indian...

First branchial cleft anomalies are quite rare, and the majority of them found in around ear canal, mostly superficial to facial nerve. Very rarely, anomalous tract first can go deeper nerve, necessitating a meticulous extensive surgery. A 21-year-old student presented with slowly increasing cystic swelling infra-auricular region. Findings magnetic resonance imaging were consistent cyst, which also exhibited extent lesion into parapharyngeal space. The entire was excised along parotidectomy...

Juvenile generalized pustular psoriasis (GPP) is an extremely rare variant of psoriasis, often accompanied by systemic symptoms. It adversely affects the psychosocial aspect child as well their caregivers. Hence, there a need for rapid control disease and induction remission at earliest possible time. In this report, we describe case 15-year-old juvenile GPP patient with history multiple relapses, who responded dramatically to secukinumab monotherapy. This report intended highlight use safer...

Background: Multidisciplinary tumor boards (MDTB) are an integral part of cancer management. However, owing to COVID 19 global pandemic it becomes a challenge have MDTBs maintaining the social distance norms. Objectives: To assess technical challenges faced during virtual board (VTB) discussion Advantages and Disadvantages VTBs. Methods: Technical support for various group meetings taking place virtually were considered. Various trials which assessed difficulties conducting such meeting...

Metastatic deposits from primary ovarian malignancy can manifest as cystic masses in the liver. In endemic areas, hydatid disease is an important differential all cases of hepatic masses. We report a case 55-year-old lady who presented with progressive abdominal distension and was diagnosed high-grade serous carcinoma. Imaging revealed concurrent lesions liver that were thought to be metastatic but later cyst based on radiologic features serology. this rare highlight importance suspecting...