A5008077462- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Ischemic Stroke Management
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Venous Thromboembolism Diagnosis and Management
- Congenital Heart Disease Studies
- Peripheral Artery Disease Management
- Cardiovascular Disease and Adiposity
- Cardiac tumors and thrombi
- Atrial Fibrillation Management and Outcomes
- ECG Monitoring and Analysis
- Cardiac electrophysiology and arrhythmias
- Heart Failure Treatment and Management
- Parathyroid Disorders and Treatments
- Aortic Disease and Treatment Approaches
- Systemic Sclerosis and Related Diseases
- Liver Disease Diagnosis and Treatment
- Healthcare cost, quality, practices
- Muscle Physiology and Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Vascular Procedures and Complications
National Institute of Cardiovascular Diseases
2021-2024
Jinnah Postgraduate Medical Center
2023
University of Karachi
2023
Pennsylvania State University
2022
Punjab Institute of Cardiology
2014-2021
Pakistan Council of Scientific & Industrial Research
2021
Weiss Memorial Hospital
2018
Saint Joseph Hospital
2018
Saifee Hospital
2016
The Royal Free Hospital
2015
BACKGROUND Prior investigation has identified factors associated with response to treatment in hepatitis C including viral genotype and titre, body weight, hepatic fibrosis, adherence therapy. The lower rate of African-Americans relative whites been previously described, but studies other racial or ethnic groups remain limited. OBJECTIVE To determine whether Asian race is an independent marker for antiviral therapy C. METHODS Data on treatment-naïve patients from a large multicenter study...
Intracoronary epinephrine has been effectively used in treating refractory no-reflow, but there is a dearth of data on its use as first-line drug normotensive patients comparison to the widely adenosine.In this open-labeled randomized clinical trial, 201 with no-reflow were 1:1 into intracoronary treatment group and adenosine control followed for 1 month. The primary end points improvement coronary flow, assessed by TIMI (Thrombolysis Myocardial Infarction) frame counts, myocardial blush....
Aim of this study was to perform quantitative evaluation high thrombus burden (Grade ≥4) as an independent predictor slow/no reflow phenomenon during primary percutaneous coronary interventions (PCI) patients with ST-segment elevation myocardial infarction (STEMI).In analytical cross-sectional we included consecutive who have undergone PCI for STEMI at a tertiary care cardiac center the Pakistan. High defined angiographic grade ≥4. The thrombolysis in (TIMI) flow rate < III phenomenon....
In this study, we developed and validated a novel risk stratification model to predict slow-flow/no-reflow (SF/NR) during the primary percutaneous coronary intervention (PCI), namely RK-SF/NR score. A total of 1,711 consecutive patients with ST-segment elevation myocardial infarction (STEMI) undergone PCI. was in development dataset tested validation dataset. The overall incidence rate SF/NR procedure 28.8% (493/1,711). final solution consisted 9 variables: female gender (points = 2),...
The incidence of myocardial infarction (MI) and its adverse effects on health mortality remain high in densely populated low- middle-income countries (LMICs). To address the issue areas timely access to primary PCI, chest pain units (CPUs) were deployed at strategic locations Karachi, with a populace over 23 million people. This study describes results this initiative expediting MI care.
Significance of total ischemic time (TIT) in the context ST-segment elevation myocardial infarction (STEMI) is still controversial. Therefore, this study, we have evaluate association TIT with immediate outcomes STEMI patients whom recommended door to balloon (DTB) less than 90 min was achieved.A 5730 were included out which 80.9% male and median age 55 [61-48] years. The DTB observed be 60 [75-45] onset chest pain emergency room (ER) arrival 180 [300-120] min. Prolonged associated poor...
Objectives: This study assessed the efficacy of using steri-strips in conjunction with conventional pneumatic trans-radial (TR) bands for achieving radial artery hemostasis after diagnostic coronary angiography (CA). With varying methods aimed at reducing compression duration post-CA via access (TRA), our aim was to evaluate time dynamics. Methodology: We randomly assigned 209 patients a 1:1 ratio receive either TR band (treatment) or alone (control) post-diagnostic CA, and followed them one...
Approximately 10% of soft tissue sarcomas are synovial sarcomas, and 90% these occur in the extremities. Among primary tumors heart, 25% malignant. Primary sarcoma heart is an extremely rare entity. A myriad investigations such as histopathology, immunohistochemistry, electron microscopy, molecular genetic techniques required for confirmation diagnosis. The tumor nearly always lethal, but surgical resection with chemotherapy may prolong life patient. We describe case a young patient arising...
Neuroblastoma is the most common solid malignant neoplasm in paediatric age group; accounting for 7% of all childhood malignancies, but neuroblastoma adult, a rare occurrence, finding mention aeons medical literature with an overall incidence 1 10 million adults/year. We report case 24-year-old male patient presenting complaints progressive abdominal distention 2 months duration. Multiple Detector Computed Tomography (MD-CT) abdomen revealed huge enhancing mass retroperitoneum abutting left...
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Objective Knowledge regarding the short-term outcomes after same-day discharge (SDD) post primary percutaneous coronary intervention (PCI) is lacking. In this study, we evaluated 1-year major adverse cardiovascular events (MACE) among SDD patients PCI. Design follow-up analysis of a subset from an existing prospective cohort study. Setting Tertiary care cardiac hospital in Karachi, Pakistan. Participants Consecutive patients, August 2019 to July 2020, with ST segment elevation myocardial...
No-reflow is a complication that frequently occurs after stenting during primary percutaneous coronary intervention. In this study, we focused on angiographic results and clinical outcomes no-reflow in the left anterior descending (LAD) artery versus non-left ST-elevation myocardial infarction (STEMI).In prospective total of 201 patients who had developed intervention were enrolled. The divided into culprit groups. endpoints final thrombolysis flow, corrected frame count blush grade....
Background: Improvement in left ventricular (LV) function after revascularization is an important determinant of long-term prognosis a patient with acute myocardial infarction (AMI). However, data on the changes LV are scarce our population. Hence, this study was conducted to evaluate and dimensions by echocardiography at 3 6 months primary percutaneous coronary intervention (PCI). Materials Methods: A total 188 patients were recruited who had undergone PCI. Patients preexistent dysfunction,...
For Southern Asian countries like Pakistan, there is inadequate evidence of risk factors associated with mortality in patients suffering from acute coronary syndrome (ACS), especially non-ST elevation ACS (NSTE-ACS) cases. Therefore, aim this study was to evaluate predictors 6-months presenting NSTE-ACS.For prospective observational we recruited adult diagnosed NSTE-ACS at a tertiary cardiac center. All he were followed-up after six months and survival status recorded. Logistic regression...
Critical Limb Ischaemia (CLI) is defined as the presence of rest pain, ulcers and/or gangrene in a limb for over 2 weeks. Associated exercise intolerance caused by muscle fibre atrophy, fibro- fatty infiltration, nerve dysfunction, mitochondrial damage and myofibril disorder. We aimed to determine behaviour satellite cells, responsible repair regeneration damaged muscle, repairing critically ischaemic adult human skeletal muscle. CD34, pax7 MyoD are all markers cells at different stages cell...
Objectives: Acute coronary syndrome (ACS) at a younger age is now becoming crucial problem. This study determined the effect of gender on clinical findings and outcomes young patients (≤ 45 years) with ACS. Methodology: In this descriptive cross sectional study, (≤45 who presented ACS underwent angiography were recruited. The comparison profile, angiographic findings, in-hospital, 90-days mortality between genders made. Results: A total 335 included, 80.6% whom men. significant difference...
Background: Group A Streptococcus (GAS) is the predominant pathogen accountable for tonsillitis, making it most prevalent and frequently encountered bacterial cause of upper respiratory infections. Although amoxicillin a prescribed antibiotic treatment tonsillopharyngitis, alternate agents like macrolides are regularly recommended. The objective this study was to evaluate compare effectiveness amoxicillin, its side effects, associated risk ratio with alternative treatments tract infections...
In Pakistan, a number of students are getting education. Some them very well educated and achieving success in their domains. Education has greater impact on student's personality its development. When professionally developed personalities, goals skills, the standard living improves hence they can also motivate other to get education for better career. Hence, by improving ratio our literacy rate giving educational environments develop with enhanced character. The reason this investigation...
Objective: The study's objective was to compare the antifungal properties of conventional and 2.5wt% neem-impregnated heat-cured PMMA through an adherence assay performed after 48 hours 30 days storage time at room temperature in distilled water. Study Design: Laboratory-based experiment. Settings: Acrylic resin specimens were prepared Dental Materials Laboratory, Peshawar College, their tests Department Microbiology, Medical Pakistan. Duration: study completed within six months from...
Right ventricular (RV) function is a major determinant of clinical outcome, but its indices have not been studied well in surgery for rheumatic valvular heart disease. The aim this study was to determine the correlation tricuspid annular plane systolic excursion (TAPSE) with outcome valve surgery.A prospective comparative conducted including 100 eligible patients who were divided into two groups based on RV as assessed by TAPSE measured two-dimensional (2D) echocardiography preoperatively....
To analyze the outcome of repair aortic valve disease associated with various types ventricular septal defect.