A5054465895- Reproductive Physiology in Livestock
- Genetic and phenotypic traits in livestock
- Advanced MRI Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Animal health and immunology
- Metabolomics and Mass Spectrometry Studies
- Veterinary Equine Medical Research
- Ruminant Nutrition and Digestive Physiology
- Reproductive System and Pregnancy
- Reproductive Biology and Fertility
- Chemokine receptors and signaling
- Effects of Environmental Stressors on Livestock
- MRI in cancer diagnosis
- Rabbits: Nutrition, Reproduction, Health
- Sperm and Testicular Function
- Veterinary Pharmacology and Anesthesia
- Cancer, Lipids, and Metabolism
- Veterinary Oncology Research
- Ovarian cancer diagnosis and treatment
- Neurological disorders and treatments
- Cardiac and Coronary Surgery Techniques
- Nasolacrimal Duct Obstruction Treatments
- Enhanced Recovery After Surgery
- Seed Germination and Physiology
- Medical Imaging Techniques and Applications
University of Turin
2014-2024
San Salvatore Hospital
2005-2024
Queen's University
2019-2023
Istituto Superiore di Sanità
2008-2023
Istituto Ortopedico Rizzoli
2022-2023
Kingston Health Sciences Centre
2023
Queens University
2023
University of Perugia
2016-2020
Innova (Italy)
2018-2019
University of Toronto
2018
Altered phosphatidylcholine (PC) metabolism in epithelial ovarian cancer (EOC) could provide choline-based imaging approaches as powerful tools to improve diagnosis and identify new therapeutic targets. The increase the major choline-containing metabolite phosphocholine (PCho) EOC compared with normal nontumoral immortalized counterparts (EONT) may derive from (a) enhanced choline transport kinase (ChoK)-mediated phosphorylation, (b) increased PC-specific phospholipase C (PC-plc) activity,...
The CXCL12/CXCR4 pathway regulates tumor cell proliferation, metastasis, angiogenesis and the tumor-microenvironment cross-talk in several solid tumors, including glioblastoma (GBM), most common fatal brain cancer. In present study, we evaluated effects of peptide R, a new specific CXCR4 antagonist that recently developed by ligand-based approach, an vitro vivo model GBM. well-characterized Plerixafor was also included study.The R on expression, survival migration were assessed human line...
Elucidation of molecular mechanisms underlying the aberrant phosphatidylcholine-cycle in cancer cells plays favor use metabolic imaging oncology and opens way for designing new targeted therapies. The anomalous choline profile detected by magnetic resonance spectroscopy (MRS) spectroscopic (MRSI) provides signatures tumor progression response to therapy. increased level intracellular phosphocholine (PCho) typically is mainly attributed upregulation kinase, responsible phosphorylation...
A composite pain scale for assessing and quantifying in rabbits (CANCRS) has been designed merging the Rabbit Grimace Scale (RbtGS) a including clinical parameters (CPS). Construct validity inter-rater reliability were assessed CANCRS, RbtGS CPS, order to test their potential detect setting. Rabbits (n = 116) either hybrids or purebreds they independently evaluated by two raters, who could be veterinarians (V) veterinary medicine students (S). Score intervals determined four classes (No...
Consumers are increasingly aware of the benefits local foods in terms quality, sustainability, animal welfare, and safety. This research addresses two main questions: (i) is perception towards sustainability aspects dairy products related to individuals’ preferences for milk cheese quality aspects? (ii) these perceptions people’s socio-demographic characteristics? For this purpose, a choice experiment was conducted online Apulia (South-East Italy) involving sample 543 respondents. A...
Aberrant choline metabolism has been proposed as a novel cancer hallmark. We recently showed that epithelial ovarian (EOC) possesses an altered MRS-choline profile, characterised by increased phosphocholine (PCho) content to which mainly contribute over-expression and activation of kinase-alpha (ChoK-alpha). To assess its biological relevance, ChoK-alpha expression was downmodulated transient RNA interference in EOC vitro models. Gene profiling microarray analysis functional performed...
Joint impact injuries initiate a progressive articular damage finally leading to post-traumatic osteoarthritis (PTOA). Racehorses represent an ideal, naturally available, animal model of the disease. Standardbred racehorses developing traumatic fetlock joint during first year their career were enrolled in our study. Age-matched controls contemporarily included. Biomarker levels equine measured serum and synovial fluid (SF) at baseline, repeated yearly over next 4 years training (from T1 T4)....
Sodium 2-propenyl thiosulfate, a water-soluble organo-sulfane sulfur compound isolated from garlic, induces apoptosis in number of cancer cells. The molecular mechanism action sodium thiosulfate has not been completely clarified. In this work we investigated, by vivo and vitro experiments, the effects on expression activity rhodanese. Rhodanese is protein belonging to family enzymes widely present all phyla reputed play distinct biological roles, such as cyanide detoxification, regeneration...
Tumor cell tolerance to nutrient deprivation can be an important factor for tumor progression, and may depend on deregulation of both oncogenes oncosuppressor proteins. Homeodomain-interacting protein kinase 2 (HIPK2) is that, following its activation by several cellular stress, induces cancer death via p53-dependent or -independent pathways. Here, we used genetically matched human RKO colon cells harboring wt-HIPK2 (HIPK2(+/+)) stable HIPK2 siRNA interference (siHIPK2) investigate in vitro...
The quality of dental arch impression has a substantial role in the precision intervention. It is traditionally acquired with resins that solidify when contact air. Compared to method, digital gives great advantages and, together three-dimensional (3D) digitization devices, allows simplification process. growing adoption such systems by large number clinics determines need for an in-depth evaluation accuracy and different systems. aim this work define methodology 3D intraoral desktop...