A5043637150- Maternal Mental Health During Pregnancy and Postpartum
- Child and Adolescent Psychosocial and Emotional Development
- Neuroscience and Music Perception
- Neonatal and fetal brain pathology
- Birth, Development, and Health
- Tryptophan and brain disorders
- Neural dynamics and brain function
- Sleep and Wakefulness Research
- Nicotinic Acetylcholine Receptors Study
- Infant Development and Preterm Care
- Stress Responses and Cortisol
- Attachment and Relationship Dynamics
- Folate and B Vitamins Research
- Early Childhood Education and Development
- Child Abuse and Trauma
- Hearing Loss and Rehabilitation
- Infant Health and Development
- Neuroscience and Neuropharmacology Research
- Neonatal Health and Biochemistry
- Advanced Causal Inference Techniques
- Prenatal Substance Exposure Effects
- Child and Animal Learning Development
- Attention Deficit Hyperactivity Disorder
- Hearing, Cochlea, Tinnitus, Genetics
- Metabolism and Genetic Disorders
University of Colorado Denver
2012-2024
University of Colorado Anschutz Medical Campus
2014-2024
Home and Community Care Support Services
2023
Cytel (United States)
2020
Children's Hospital Colorado
2017-2020
New York Hospital Queens
2017
NewYork–Presbyterian Hospital
2017
Amgen (United States)
2016
Denver Health Medical Center
2012-2015
Colorado School of Public Health
2015
This is an exciting and highly important paper describing a novel perinatal treatment of risk factor for schizophrenia. Deficient cerebral inhibition brain deficit related to poor sensory gating attention in schizophrenia other disorders. develops perinatally, influenced by genetic utero factors. Amniotic choline activates fetal α7-nicotinic acetylcholine receptors facilitates development inhibition. Increasing this activation may protect infants from future illness promoting normal...
Objective: α7-Nicotinic receptors are involved in the final maturation of GABA inhibitory synapses before birth. Choline at levels found amniotic fluid is an agonist α7-nicotinic receptors. The authors conducted a double-blind placebo-controlled trial to assess whether high-dose oral phosphatidylcholine supplementation during pregnancy increase maternal choline would enhance fetal development cerebral inhibition and, as result, decrease childhood behavior problems associated with later...
In 1997, Vogelzang et al. reported that 61 % of patients with cancer indicated fatigue impacted daily life more than pain, and only 37 oncologists shared this perception. We provide an update to study, which can help prioritize symptom assessment management in the clinic. Study aims were determine compare perceptions health care providers (HCPs) impact pain. A random sample was recruited USA by Harris Poll Online Schlesinger Associates. Oncology HCPs Food Drug Research, Inc. Toluna, From...
Abstract Background Maternal inflammation in early pregnancy has been identified epidemiologically as a prenatal pathogenic factor for the offspring's later mental illness. Early newborn manifestations of effects maternal on human fetal brain development are largely unknown. Methods infection, depression, obesity, and other factors associated with were assessed at 16 weeks gestation, along C-reactive protein (CRP), cytokines, serum choline. Cerebral inhibition was by inhibitory P50 sensory...
When behavioral problems resulting from attentional difficulties present, often in preschool, it is unknown whether these represent preexisting altered brain development or new changes. This study examines infant sensory gating of auditory evoked potentials predicts parent-reported behavior at 40 months.P50 gating, an potential measure reflective inhibitory processes the brain, was measured 50 infants around 70 days old. Parents, using Child Behavior Checklist, reported on child's...
Objective: Prenatal maternal anxiety has detrimental effects on the offspring's neurocognitive development, including impaired attentional function. Antidepressants are commonly used during pregnancy, yet their impact offspring attention and interaction with not been assessed. The authors P50 auditory sensory gating, a putative marker of early processes measurable in young infants, to assess antidepressant use. Method: A total 242 mother-infant dyads were classified relative history prenatal...
Abstract Choline and folate are critical nutrients for fetal brain development, but the timing of their influence during gestation has not been previously characterized. At different periods gestation, choline stimulation α7‐nicotinic receptors facilitates conversion γ‐aminobutyric acid (GABA) from excitatory to inhibitory recruitment GluR1‐R2 faster responses glutamate. The outcome development inhibition excitation was assessed in 159 newborns by P50 cerebral auditory‐evoked responses....
Diminished inhibitory gating of cerebral auditory evoked responses is transmitted in families with psychoses as an endophenotype related to the genetic risk for these illnesses. To assess whether already expressed infants parents psychotic illness and effects other known factors schizophrenia, ie, maternal cigarette smoking depression, was evaluated by comparing P1 first second paired stimuli. Cerebral were recorded during active sleep from 22 a parent diagnosed 129 no such history. Of...
Infant resting-state networks do not exhibit the same connectivity patterns as those of young children and adults. Current theories brain development emphasize developmental progression in regional network specialization. We compared infant adult functional connectivity, predicting that infants would less specificity greater internetwork communication with adults.Functional magnetic resonance imaging at rest was acquired 12 healthy, term 17 Resting-state were extracted, using independent...
This study assessed reliability of auditory sensory gating in young infants from 1–4 months age using a paired-click paradigm which 'clicks' were presented at an interstimulus interval 500 ms. Evoked potential component P1 was measured during periods active sleep on two different occasions. Amplitudes, latencies, and ratio the evoked potentials to each clicks compared. Significant found response ratio, latency first stimulus, amplitude second with trend toward significance for stimulus...
Abstract Background Prenatal choline is a key nutrient, like folic acid and vitamin D, for fetal brain development subsequent mental function. We sought to determine whether effects of higher maternal plasma concentrations on childhood attention social problems, found in an initial clinical trial supplementation, are observed second cohort. Methods Of 183 mothers enrolled from urban safety net hospital clinic, 162 complied with gestational assessments brought their newborns study at 1 month...
Biological traits that are predictive of the later development psychosis have not yet been identified. The complex, multidetermined nature schizophrenia and other psychoses makes it unlikely any single biomarker will be both sensitive specific enough to unambiguously identify individuals who become psychotic. However, current genetic research has begun genes associated with schizophrenia, some which phenotypes appear early in life. While these low power for identifying psychotic, they do...
This study investigated whether higher maternal choline levels mitigate effects of marijuana on fetal brain development. Choline transported into the amniotic fluid from mother activates α7-nicotinic acetylcholine receptors cerebro-cortical inhibitory neurons, whose development is impeded by cannabis blockade their cannabinoid-1(CB1) receptors.
Abstract Black Americans have increased risk for schizophrenia and other mental illnesses with prenatal origins. Prenatal choline promotes infant brain development behavioral outcomes, but has not been specifically assessed in Americans. Pregnant women (N = 183, N 25 Americans) enrolled a study of stressors interactions choline. American had lower 16-week gestation plasma than Whites. Lower was related to obesity, income, or metabolic genotypes. rural Uganda higher levels women. Americans’...
This study examined the effect of attention in young infants on saccadic localization peripheral stimuli. Infants ranging age from 5 to 14 weeks were tested using a stimulus detection paradigm. The presence central fixation decreased probability, particularly if was engaged with stimulus. Peripheral usually accomplished single eye movement. When by multiple movements, corrective saccades occurred most frequently and fixed‐amplitude hypometric less frequently. A decrease slope linear...