A5017154876- Sepsis Diagnosis and Treatment
- Nosocomial Infections in ICU
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- Intensive Care Unit Cognitive Disorders
- Thermal Regulation in Medicine
- Antibiotic Use and Resistance
- Venous Thromboembolism Diagnosis and Management
- Antibiotics Pharmacokinetics and Efficacy
- Anesthesia and Neurotoxicity Research
- Respiratory Support and Mechanisms
- Online and Blended Learning
- Hematological disorders and diagnostics
- Clostridium difficile and Clostridium perfringens research
- Anesthesia and Sedative Agents
- Inhalation and Respiratory Drug Delivery
- Innovative Teaching and Learning Methods
- Heparin-Induced Thrombocytopenia and Thrombosis
- Orthopedic Infections and Treatments
- Healthcare Decision-Making and Restraints
- Innovations in Medical Education
- Adrenal Hormones and Disorders
- Drug-Induced Adverse Reactions
- Appendicitis Diagnosis and Management
University of Wisconsin Health
2022-2024
Mayo Clinic
2019-2021
Mayo Clinic Hospital
2018-2021
National Park Service
2020
Aurora BayCare Medical Center
2015-2019
University of Minnesota Rochester
2019
Barnes-Jewish Hospital
2007-2015
Washington University in St. Louis
2009-2015
Jewish Hospital
2012
Objective: The objective of this study was to determine whether persistent lymphopenia on the fourth day following diagnosis sepsis predicts mortality. Methods: This a single-center, retrospective cohort 335 adult patients with bacteremia and admitted large university-affiliated tertiary care hospital between January 1, 2010, July 31, 2012. All complete blood cell count profiles during first 4 days were recorded. primary outcome 28-day Secondary outcomes included development secondary...
The objective of this study was to compare the observed rates ventilator-associated pneumonia when using National Healthcare Safety Network vs. American College Chest Physicians criteria.Prospective, observational cohort study.A 1250-bed academic tertiary care medical center.Adult and surgical intensive unit patients requiring mechanical ventilation for >48 hrs.None.Patients were prospectively independently screened from January 2009 2010 criteria. All classifications, including...
Patients with intra-abdominal sepsis and associated bacteremia have a high mortality rate. However, outcomes studies in this population are limited, part because of the small numbers such patients. The objective study was to describe characteristics critically ill patients secondary blood stream infection (BSI) origin identify predictors mortality.This retrospective, single-center evaluated admitted between January 2005 2011 an source. were included if they met criteria for severe based on...
To determine whether hypothermia within 24 hours of sepsis diagnosis is associated with development persistent lymphopenia, a feature sepsis-induced immunosuppression.Retrospective cohort study.A 1,200-bed university-affiliated tertiary care hospital.Adult patients diagnosed bacteremia and 5 days hospital admission between January 1, 2010, July 31, 2012.None.Leukocyte counts were recorded during the first 4 following diagnosis. Persistent lymphopenia was defined as an absolute lymphocyte...
To compare heparin (3 mL, 10 units/mL) and 0.9% sodium chloride (NaCl, mL) flush solutions with respect to central venous catheter lumen patency.Single-center, randomized, open label trial.Medical intensive care unit Surgical/Burn/Trauma at Barnes-Jewish Hospital, St. Louis, MO.Three hundred forty-one patients multilumen catheters. Patients least one a minimum of two flushes were included in the analysis.Patients randomly assigned within 12 hrs insertion receive either or flush.The primary...
To compare the effectiveness of bivalirudin and argatroban in achieving anticoagulation goals to clinical outcomes assessing safety efficacy patients with known or suspected heparin-induced thrombocytopenia (HIT).Single-center, retrospective analysis.Large tertiary care academic medical center.A total 138 adults who received either (92 patients) (46 for at least 24 hours HIT between January 2007 July 2008. MEASUREMENTS AND MAIN RESULTS. Data regarding demographics, direct thrombin inhibitor...
BACKGROUND: β-Lactam antibiotics demonstrate time-dependent killing. Prolonged infusion of these agents is commonly performed to optimize the time unbound concentration an antibiotic remains greater than minimum inhibitory and decrease costs, despite limited evidence suggesting improved clinical results. OBJECTIVE: To determine whether prolonged β-lactam improves outcomes in critically ill patients with suspected gram-negative infection. METHODS: We conducted a single-center, before-after,...
Investigations of the relationship between vancomycin trough concentrations and area under concentration time curve (AUC) are growing, but still limited. The authors sought to determine exposure among hospitalized adults with presumed or confirmed invasive staphylococcal infections using 2-level pharmacokinetic monitoring inform changes an institutional dosing protocol.This was a retrospective observational study performed in 2 acute care hospitals. Adults prescribed (therapeutic 15-20 mg/L)...
<h3>BACKGROUND:</h3> Nosocomial pneumonia is a difficult diagnosis to establish in the intensive care unit setting, due non-specific nature of clinical and radiographic findings. Procalcitonin circulating biomarker that may become elevated presence bacterial infection. <h3>METHODS:</h3> We conducted prospective single-center cohort study at Barnes-Jewish Hospital, 1,200-bed urban teaching hospital St Louis, Missouri. In medical surgical patients with suspected nosocomial we measured plasma...
ARDS is an important cause of respiratory failure and continues to be associated with a high mortality rate. Numerous therapeutic interventions have been employed improve patient outcomes, including inhaled epoprostenol.We examined subjects treated epoprostenol. We compared hospital survivors nonsurvivors identify predictors mortality.Among the cohort (n=216), there were 80 (37%) 136 (63%) nonsurvivors. Logistic regression revealed 5 variables mortality: trauma as etiology for (adjusted odds...
Survey of Anesthesiology: December 2012 - Volume 56 Issue 6 p 273-275 doi: 10.1097/01.SA.0000422035.91638.f9
Abstract Introduction Randomized controlled trials suggest clinical outcomes may be improved with dexmedetomidine as compared benzodiazepines; however, further study and validation are needed. The objective of this was to determine the effectiveness a sedation protocol minimizing benzodiazepine use in favor early dexmedetomidine. Methods We conducted before-after including adult surgical medical intensive care unit (ICU) patients requiring mechanical ventilation continuous for at least 24...
The American Society of Health-System Pharmacists residency accreditation standards require all postgraduate training programs to teach and evaluate a resident's ability advance practice through project development presentation, underscoring the importance conducting research in today's professional climate. Although many residents express strong interest participation contributing medical literature, obstacles publication have been identified. We aim illustrate deliberate approach teaching...
Purpose To validate the Motivated Strategies for Learning Questionnaire (MSLQ), which measures learner motivations; and Instructional Materials Motivation Survey (IMMS), motivational properties of educational activities.