A5015771196- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- Antimicrobial Peptides and Activities
- Natural product bioactivities and synthesis
- Fungal Biology and Applications
- Osteoarthritis Treatment and Mechanisms
- Protein Tyrosine Phosphatases
- Bacteriophages and microbial interactions
- Plant Pathogens and Fungal Diseases
- Photoreceptor and optogenetics research
- Polydiacetylene-based materials and applications
- Mass Spectrometry Techniques and Applications
- Chemical synthesis and alkaloids
- Bioactive Compounds and Antitumor Agents
- Phytochemical compounds biological activities
- Ion Transport and Channel Regulation
- RNA Interference and Gene Delivery
Beihang University
2023-2025
Ocean University of China
2020-2022
Qingdao National Laboratory for Marine Science and Technology
2020-2022
Second Military Medical University
2017
Radboud University Nijmegen
1989
Osteoarthritis (OA) leads to the progressive degeneration of articular cartilage, yet there is currently no effective treatment available for both early and late stages osteoarthritis. Cartilage regeneration requires action prolonged retention multiple drugs at injured sites recruit endogenous cells facilitate cartilage formation. Here, we propose a cartilage-binding-peptide-modified lipid nanoparticle as drug carrier achieve sustained release protein (TGF-β3) small molecular (KGN) one...
We isolated and identified a new sesquiterpene lactone which we named eut-Guaiane (1), along with four cytochalasins from the fungus Eutypella sp. derived soil of high latitude Arctic. The structure was determined by spectroscopic studies such as 1D 2D NMR MS analyses, while known compounds were comparison data those in literatures. New compound 1 exhibited strong antibacterial activity against Escherichia coli, Bacillus subtilis Staphylococcus aureus. Besides, it showed little cytotoxicity...
OSMAC approach was performed on the soft coral-derived fungus Trichoderma harzianum (XS-20090075) leading to significant changes of its secondary metabolites by using two different cultures. A new naphthalene derivative, trichoharzin B (1) and a natural product, methyl-trichoharzin (2) were isolated rice medium. Whereas, ethyl 2-bromo-4-chloroquinoline-3-carboxylate (9) obtained Czapek's Their structures established extensive spectroscopic investigation. The absolute configuration 5...
A new furanone derivative, butanolide (1), and a sesquiterpene, guignarderemophilane F (2), together with six known compounds, were isolated from the fungus Penicillium sp. S-1-18 derived Antarctic marine. The structures determined by spectroscopic studies such as 1D- 2D-NMR MS analyses. absolute configuration of 1 was modified Mosher's method, while 2 calculated ECD spectroscopy. secondary metabolites evaluated for their protein tyrosine phosphatase 1B (PTP1B) inhibitory activity. Compound...
The biotransformation of total coumarins Radix Glehniae by Lecanicillium attenuatum W-1-9 yielded three new products, lecaniside A (1), B (2), and C (3). chemical structures these metabolites were elucidated based on extensive spectral data, including 2D NMR HRMS. hydrogenation, dealkylation, glycosylation, O-methylation reactions observed in the present study. In vitro assays, compound 1 displayed a little PTP1B inhibitory activity.